Results 31 to 40 of about 26,266 (223)

Tissue Cytokine Responses in Canine Visceral Leishmaniasis [PDF]

, 2001
To elucidate the local tissue cytokine response of dogs infected with Leishmania chagasi, cytokine mRNA levels were measured in bone marrow aspirates from 27 naturally infected dogs from Brazil and were compared with those from 5 uninfected control ...
Courtenay, O., Day, M.J., Dye, C., Garcez, L.M., Kaye, P.M., Quinnell, R.J., Shaw, M.-A.   +6 more
core   +2 more sources

Modulation of Cytokines and Extracellular Matrix Proteins Expression by Leishmania amazonensis in Susceptible and Resistant Mice [PDF]

Frontiers in Microbiology, 2020
Leishmaniases are a complex of diseases with a broad spectrum of clinical forms, which depend on the parasite species, immunological status, and genetic background of the host. In the Leishmania major model, susceptibility is associated with the Th2 pattern of cytokines production, while resistance is associated with Th1 response.
Flávia de Oliveira Cardoso, Tânia Zaverucha-do-Valle, Fernando Almeida-Souza, Fernando Almeida-Souza, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese   +5 more
openaire   +3 more sources

Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis

Frontiers in Immunology, 2022
The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania, the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severity.
Tirza Gabrielle Ramos de Mesquita, Tirza Gabrielle Ramos de Mesquita, José do Espírito Santo Junior, José do Espírito Santo Junior, Luan Diego Oliveira da Silva, George Allan Villarouco Silva, Felipe Jules de Araújo, Felipe Jules de Araújo, Suzana Kanawati Pinheiro, Suzana Kanawati Pinheiro, Herllon Karllos Athaydes Kerr, Lener Santos da Silva, Lener Santos da Silva, Luciane Macedo de Souza, Samir Assad de Almeida, Krys Layane Guimarães Duarte Queiroz, Josué Lacerda de Souza, Josué Lacerda de Souza, Cilana Chagas da Silva, Héctor David Graterol Sequera, Héctor David Graterol Sequera, Mara Lúcia Gomes de Souza, Mara Lúcia Gomes de Souza, Anderson Nogueira Barbosa, Gemilson Soares Pontes, Gemilson Soares Pontes, Gemilson Soares Pontes, Marcus Vinitius de Farias Guerra, Marcus Vinitius de Farias Guerra, Rajendranath Ramasawmy, Rajendranath Ramasawmy, Rajendranath Ramasawmy, Rajendranath Ramasawmy   +32 more
openaire   +3 more sources

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +5 more sources

FML/QuilA‐Vaccinated Dogs Naturally Infected with Leishmania infantum: Serum Cytokines, Clinicopathological Profile, and Parasitological Parameters [PDF]

BioMed Research International, 2021
Dogs are the main reservoir of Leishmania infantum in endemic regions. Canine leishmaniasis, caused by L. infantum, can progress to a chronic disease resulting in death. Vaccines have been developed with a certain degree of success. The pathogenesis of this disease is not completely understood, especially in previously vaccinated dogs.
Gregório Guilherme Almeida, Fernanda Morcatti Coura, Jonata de Melo Barbieri, Ana Carolina Junqueira Moura, Fabiola de Oliveira Paes-Leme, Adriane Pimenta da Costa-Val   +5 more
openaire   +2 more sources

The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil

Journal of Immunology Research, 2014
The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil.
Thaís Tibery Espir, Luanda de Paula Figueira, Maricleide de Farias Naiff, Allyson Guimarães da Costa, Marcelo Ramalho-Ortigão, Adriana Malheiro, Antonia Maria Ramos Franco   +6 more
doaj   +1 more source

In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni [PDF]

, 2007
The cytokine interplay during the development of protective immunity to the radiation-attenuated (RA) schistosome vaccine has been extensively characterized over recent years, yet the role of costimulatory molecules in the development of cell-mediated ...
Hamblin, Paul A, Hewitson, James P, Mountford, Adrian P   +2 more
core   +2 more sources

Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
The immune response in leishmaniasis may result in a polarization of the T lymphocyte subpopulation, altering cell phenotype and resulting in immune protection or disease exacerbation. Leishmania may persist in the body either during asymptomatic infections or after treatment, which represents high risk under immunosuppression.
Hoffmann, J. L., Machado, J. G., Gaio, Fernanda Conceição, Dias-Melicio, L. A., Langoni, Hélio   +4 more
openaire   +5 more sources

Macrophages From Subjects With Isolated GH/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection by Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2019
Isolated growth hormone (GH) deficiency (IGHD) affects approximately 1 in 4,000 to 1 in 10,000 individuals worldwide. We have previously described a large cohort of subjects with IGHD due to a homozygous mutation in the GH releasing hormone (GHRH ...
Mônica R. Barrios, Viviane C. Campos, Nalu T. A. Peres, Nalu T. A. Peres, Laís L. de Oliveira, Rodrigo A. Cazzaniga, Márcio B. Santos, Murilo B. Aires, Ricardo L. L. Silva, Aline Barreto, Hiro Goto, Hiro Goto, Roque P. Almeida, Roberto Salvatori, Manuel H. Aguiar-Oliveira, Amélia M. R. Jesus   +15 more
doaj   +1 more source

How to B(e)-1 Important Cell During Leishmania Infection

Frontiers in Cellular and Infection Microbiology, 2020
B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a and B-1b distinguished by the presence or absence of CD5, respectively.
Luan Firmino-Cruz, Luan Firmino-Cruz, Debora Decote-Ricardo, Daniel Claudio de Oliveira Gomes, Alexandre Morrot, Alexandre Morrot, Celio Geraldo Freire-de-Lima, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes   +9 more
doaj   +1 more source