Results 61 to 70 of about 26,266 (223)

Unravelling the unsolved paradoxes of cytokine families in host resistance and susceptibility to Leishmania infection

Cytokine: X, 2020
Leishmaniasis is a neglected disease caused by protozoan parasites of the genus Leishmania. Successful clearance of Leishmania relies on a robust human immune response and various cytokines have been implicated in resistance and susceptibility to Leishmania infection.
Bernard Ong'ondo Osero, Raphael Taiwo Aruleba, Frank Brombacher, Ramona Hurdayal   +3 more
openaire   +2 more sources

CD100/Sema4D Increases Macrophage Infection by Leishmania (Leishmania) amazonensis in a CD72 Dependent Manner

Frontiers in Microbiology, 2018
Leishmaniasis is caused by trypanosomatid protozoa of the genus Leishmania, which infect preferentially macrophages. The disease affects 12 million people worldwide, who may present cutaneous, mucocutaneous or visceral forms.
Mariana K. Galuppo, Eloiza de Rezende, Fabio L. Forti, Mauro Cortez, Mario C. Cruz, Andre A. Teixeira, Ricardo J. Giordano, Beatriz S. Stolf   +7 more
doaj   +1 more source

Extracellular vesicles from Leishmania-infected macrophages confer an anti-infection cytokine-production profile to naïve macrophages. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND:Extracellular vesicles (EVs) are structures with phospholipid bilayer membranes and 100-1000 nm diameters. These vesicles are released from cells upon activation of surface receptors and/or apoptosis.
André Cronemberger-Andrade, Luciana Aragão-França, Cintia Figueiredo de Araujo, Viviane Junqueira Rocha, Mariana da Cruz Borges-Silva, Cláudio P Figueira, Pablo R Oliveira, Luiz A R de Freitas, Patrícia S T Veras, Lain Pontes-de-Carvalho   +9 more
doaj   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

CD8+ T cells in Leishmania infections: friends or foes?

Frontiers in Immunology, 2012
Host protection against several intracellular pathogens requires the induction of CD8+ T cell responses. CD8+ T cells are potent effector cells that can produce high amounts of pro-inflammatory cytokines and kill infected target cells efficiently ...
Simona eStager, Sima eRafati
doaj   +1 more source

Recombinant Amelogenin as a Potential Alternative to Enamel Matrix Derivatives in Periodontal Regeneration: A Scoping Review of Its Biological Activity, Synthesis and Delivery Systems

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objective The objective of this review is to evaluate the existing literature on the regenerative potential of recombinant amelogenin, with a particular emphasis on the biological activity, synthesis, and delivery systems relevant to periodontal regeneration.
Jie Dan Denny Luo, Jennifer Mardini, Raymond Lee, Fariba Dehghani, Aaron Schindeler   +4 more
wiley   +1 more source

Impaired Expression of Inflammatory Cytokines and Chemokines at Early Stages of Infection withLeishmania amazonensis [PDF]

Infection and Immunity, 2003
ABSTRACTInfection of mice withLeishmania majorresults in disease progression or resolution, largely depending on the genetic backgrounds of the mouse strains. Infection withLeishmania amazonensis, on the other hand, causes progressive cutaneous lesions in most inbred strains of mice.
Jiaxiang, Ji, Jiaren, Sun, Lynn, Soong
openaire   +2 more sources

Function of Macrophage and Parasite Phosphatases in Leishmaniasis

Frontiers in Immunology, 2017
The kinetoplastid protozoan parasites belonging to the genus Leishmania are the causative agents of different clinical forms of leishmaniasis, a vector-borne infectious disease with worldwide prevalence.
Didier Soulat, Didier Soulat, Christian Bogdan, Christian Bogdan   +3 more
doaj   +1 more source

Efficacy of an Immunotherapy Combining Immunogenic Chimeric Protein Plus Adjuvant and Amphotericin B against Murine Visceral Leishmaniasis

Biology, 2023
Visceral leishmaniasis (VL) in the Americas is a chronic systemic disease caused by infection with Leishmania infantum parasites. The toxicity of antileishmanial drugs, long treatment course and limited efficacy are significant concerns that hamper ...
Danniele L. Vale, Camila S. Freitas, Vívian T. Martins, Gabriel J. L. Moreira, Amanda S. Machado, Fernanda F. Ramos, Isabela A. G. Pereira, Raquel S. Bandeira, Marcelo M. de Jesus, Grasiele S. V. Tavares, Fernanda Ludolf, Miguel A. Chávez-Fumagalli, Alexsandro S. Galdino, Ricardo T. Fujiwara, Lílian L. Bueno, Bruno M. Roatt, Myron Christodoulides, Eduardo A. F. Coelho, Daniela P. Lage   +18 more
doaj   +1 more source

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Blount, Daniel G, Couper, Kevin N, de Souza, J Brian, Greig, Rachel, Gwyer Findlay, Emily, Hafalla, Julius CR, Hunter, Christopher A, Riley, Eleanor M, Shaw, Tovah N, Stumhofer, Jason S, Villegas-Mendez, Ana   +10 more
core   +1 more source