Results 71 to 80 of about 26,266 (223)

One-year timeline kinetics of cytokine-mediated cellular immunity in dogs vaccinated against visceral leishmaniasis [PDF]

, 2015
BACKGROUND: The main control strategy for visceral leishmaniasis in Brazil has been based on the elimination of seropositive dogs, although this is not widely accepted. In this context, the use of a long-lasting protective vaccine against canine visceral
Bruno H Marteleto, Christiane Costa-Pereira, Kelvinson F Viana, Ludmila M Cardoso, Marcela L Moreira, Michelle H França-Dias, Márcio S S Araújo, Olindo A Martins-Filho, Rodolfo C Giunchetti, Rodrigo P Soares, Vitor M Ribeiro   +10 more
core   +2 more sources

The role of T cells in sepsis of distinct infectious aetiologies

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu, Bijun Zhu, Wanxin Duan, Ruixiang Kang, Xiangdong Wang, Liyang Li   +5 more
wiley   +1 more source

Dynamics of immunosuppression in hamsters with experimental visceral leishmaniasis

Brazilian Journal of Medical and Biological Research, 2011
Immunosuppression has been reported to occur during active visceral leishmaniasis and some factors such as the cytokine profile may be involved in this process.
C. Fazzani, P.A. Guedes, A. Senna, E.B. Souza, H. Goto, J.A.L. Lindoso   +5 more
doaj   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Evaluating the Effects of Imiquimod on Paths of TLRs and Inflammatory Cytokines Signaling in Infected Macrophages with Leishmania major in Vitro and in Vivo

Iranian Journal of Parasitology
Background: Leishmania major is an obligate and intracellular pathogen and the macrophages are the cell hosts for L. major. Imiquimod stimulates macrophages to secrete different cytokines via the expression of TLRs.
Parisa Ebrahimisadr, Fatemeh Ghaffarifar, Javad Jabari, John Horton, Zohreh Sharifi, Abdolhossein Dalimi, Mohammad Saaid Dayer   +6 more
doaj   +1 more source

All-Trans Retinoic Acid Promotes an M1- to M2-Phenotype Shift and Inhibits Macrophage-Mediated Immunity to Leishmania major

Frontiers in Immunology, 2017
As key cells, able to host and kill Leishmania parasites, inflammatory monocytes/macrophages are potential vaccine and therapeutic targets to improve immune responses in Leishmaniasis.
Natália S. Vellozo, Sâmara T. Pereira-Marques, Mariela P. Cabral-Piccin, Alessandra A. Filardy, Alessandra A. Filardy, Flávia L. Ribeiro-Gomes, Flávia L. Ribeiro-Gomes, Thaís S. Rigoni, George A. DosReis, George A. DosReis, Marcela F. Lopes   +10 more
doaj   +1 more source

PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection. [PDF]

PLoS Neglected Tropical Diseases, 2015
Parasites of the Leishmania genus infect and survive within macrophages by inhibiting several microbicidal molecules, such as nitric oxide and pro-inflammatory cytokines.
Marina Tiemi Shio, Jan Gregor Christian, Jee Yong Jung, Kwang-Poo Chang, Martin Olivier   +4 more
doaj   +1 more source

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, Volume 600, Issue 5, Page 693-709, March 2026.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis

PLOS Neglected Tropical Diseases, 2016
The absence of an effective vaccine and the debilitating chemotherapy for Leishmaniasis demonstrate the need for developing alternative treatments. Several studies conducted with Morinda citrifolia have shown various biological activities, including antileishmanial activity, however its mechanisms of action are unknown.
Fernando Almeida-Souza, Flávia de Oliveira Cardoso, Bruno Vinicius da Conceição Souza, Tânia Zaverucha do Valle, Joicy Cortez de Sá, Iara Dos Santos da Silva Oliveira, Celeste da Silva Freitas de Souza, Carla Junqueira Moragas Tellis, Maria do Socorro Dos Santos Chagas, Maria Dutra Behrens, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese   +11 more
openaire   +4 more sources

Expression of TLR2 and TLR4 in lesions of patients with tegumentary american leishmaniasis

Revista do Instituto de Medicina Tropical de São Paulo, 2012
OBJECTIVES: The aim of this study was to describe the pattern of expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in skin biopsies of patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis ...
Felipe Francisco Tuon, Elaine Ribeiro Fernandes, Maria Irma Seixas Duarte, Valdir Sabbaga Amato   +3 more
doaj   +1 more source