Results 81 to 90 of about 26,266 (223)

Absence of metalloprotease GP63 alters the protein content of Leishmania exosomes. [PDF]

PLoS ONE, 2014
Protozoan parasites of Leishmania genus are able to successfully infect their host macrophage due to multiple virulence strategies that result in its deactivation.
Kasra Hassani, Marina Tiemi Shio, Caroline Martel, Denis Faubert, Martin Olivier   +4 more
doaj   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, Volume 13, Issue 16, 18 March 2026.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Exosome Secretion by the Parasitic Protozoan Leishmania within the Sand Fly Midgut

Cell Reports, 2015
Despite several studies describing the secretion of exosomes by Leishmania in vitro, observation of their formation and release in vivo has remained a major challenge.
Vanessa Diniz Atayde, Hamide Aslan, Shannon Townsend, Kasra Hassani, Shaden Kamhawi, Martin Olivier   +5 more
doaj   +1 more source

A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis [PDF]

Previous studies demonstrated safety, immunogenicity and efficacy of DNA/modified vaccinia virus Ankara (MVA) prime/boost vaccines expressing tryparedoxin peroxidase (TRYP) and Leishmania homologue of the mammalian receptor for activated C kinase (LACK ...
Alcami, Antonio, Antoniou, Maria, Begoña Ruiz-Argüello, Maria, Blackwell, Jenefer M., Carson, Connor, Christodoulou, Vasiliki, Courtenay, Orin, Messaritakis, Ippokratis   +7 more
core   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio, Alvarez, Emilio, Bardera, Ana I., Barroso, Vanessa, Brown, James R., Cantizani, Juan, Colmenarejo, Gonzalo, Cotillo, Ignacio, de Dios-Anton, Francisco, Drewry, David H., Fiandor, Jose M., Gray, David W., Julio Martin, J., Kessler, Albane, Kumar, Vinod, Navarro, Miguel, Peña, Imanol, Pilar Manzano, M., Rodriguez, Ana, Roquero, Irene, Sherstnev, Alexander   +20 more
core   +3 more sources

Oxidative costs of migration: infections as an added burden

Journal of Avian Biology, Volume 2026, Issue 2, March 2026.
There is increasing evidence that over‐production of reactive species (RS) constitutes a significant physiological cost for migrating birds. The current view entails that RS during migration originate primarily from increased metabolic activity associated with prolonged flights and refueling.
Michael Tobler, Dennis Hasselquist, Arne Hegemann, Lucía Jiménez‐ Gallardo, Javier Pérez‐ Tris, Carolina Remacha   +5 more
wiley   +1 more source

Extracellular Vesicles Released by Leishmania (Leishmania) amazonensis Promote Disease Progression and Induce the Production of Different Cytokines in Macrophages and B-1 Cells

Frontiers in Microbiology, 2018
The extracellular vesicles (EVs) released by Leishmania can contribute to the establishment of infection and host immunomodulation. In this study, we characterized the shedding of EVs from Leishmania (Leishmania) amazonensis promastigotes. This species is the causative agent of cutaneous leishmaniasis, and its role during interactions with bone marrow ...
Fernanda Marins Costa Barbosa, Talita Vieira Dupin, Mayte dos Santos Toledo, Natasha Ferraz dos Campos Reis, Kleber Ribeiro, André Cronemberger-Andrade, Jeronimo Nunes Rugani, Beatriz Helena Pizarro De Lorenzo, Ronni Rômulo Novaes e Brito, Rodrigo Pedro Soares, Ana Claudia Torrecilhas, Patricia Xander   +11 more
openaire   +3 more sources

Regulation of immunity during visceral Leishmania infection [PDF]

, 2016
Unicellular eukaryotes of the genus Leishmania are collectively responsible for a heterogeneous group of diseases known as leishmaniasis. The visceral form of leishmaniasis, caused by L. donovani or L.
A Caldas, A Campos-Neto, A Cope, A Gallimore, A Hammami, A Maroof, A Maroof, A Nieto, A Schietinger, AC Ghose, AC Stanley, AC Stanley, AJ Zajac, AM Mangoud, Anabela Cordeiro-da-Silva, AP Freitas do Rosario, B Galvao-Castro, BM Owens, BN Thomas, BT Edelson, BT Edelson, C Trez De, C Zaph, CR Engwerda, CR Engwerda, CR Engwerda, CR Engwerda, CR Engwerda, CR Engwerda, D Jankovic, D Nandan, DA Vignali, DL Sacks, DR Faria, E Cillari, EJ Wherry, EJ Wherry, EM Carvalho, F Chappuis, F Real, F Robert-Gangneux, F Woelbing, FO Novais, G Arango Duque, G Matlashewski, GD Victora, GR Cooper, H Aslan, HT Jin, HT Jin, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, I Muller, I Muller, I Vouldoukis, J Alvar, J Chavas, J Griensven van, J Lehmann, J Zhu, JE Dalton, JG Cyster, JJ Stern, JL Amprey, JP Gigley, JS Cervia, JS Yi, JW Moore, Jérôme Estaquier, K Ghosh, KE Squires, KJ Esch, KN Gibson-Corley, KN Gibson-Corley, L Beattie, L Beattie, L Beattie, LE Rosas, LE Rosas, LE Smith, LU Buxbaum, M Ato, M Barral-Netto, M Guilliams, M Olivier, M Resende, M Saraiva, M Svensson, M Svensson, MA Nolte, MC Cumont, MC Tumang, ME Wilson, ME Wilson, MG Pitta, Mireille Laforge, MJ McElrath, ML Murphy, ML Murphy, MM Kane, MS Nascimento, N Rolao, N Santarem, NA Ansari, NA Gomes, ND Glennie, OP Singh, OP Singh, P Gallo, P Kaye, P Tsagozis, P Tsagozis, P Yurdakul, PA Kager, PM Gorak, PM Kaye, PT Bunn, R Badaro, R Bankoti, R Kumar, R Phillips, R Polley, R Polley, R Polley, R Porrozzi, RD Pearson, RE Mebius, Ricardo Silvestre, RJ Faleiro, RT Kenney, S Bhattacharyya, S Crotty, S Gautam, S Gautam, S Honore, S Ito, S Karmakar, S Kaur, S Lopez Kostka, S Nakayamada, S Nylen, S Nylen, S Oghumu, S Santos Cda, S Stager, S Stager, SA Costa Lima, SA Miles, SC Smelt, SC Smelt, SE Cotterell, SL Colpitts, SM Kaech, T Joshi, V Diniz-Atayde, V Leclercq, V Peruhype-Magalhaes, V Rodrigues, Vasco Rodrigues, VL Matta da, W Ouyang, WE Agu, WG Shreffler, Y Belkaid   +170 more
core   +5 more sources

Dysbiosis in the Pathogenesis of Atopic Dermatitis

The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley   +1 more source

Phage-fused epitopes from Leishmania infantum used as immunogenic vaccines confer partial protection against Leishmania amazonensis infection [PDF]

, 2016
Two mimotopes of Leishmania infantum identified by phage display were evaluated as vaccine candidates in BALB/c mice against Leishmania amazonensis infection.
Coelho, Eduardo A. F., Costa, Lourena E., Soto, Manuel   +2 more
core   +1 more source