Results 171 to 180 of about 53,736 (284)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos   +16 more
wiley   +1 more source

The cytokinin histidine kinase receptors regulate nodulation, shoot and root development in <i>Pisum sativum</i>. [PDF]

open access: yesFront Plant Sci
Velandia K   +11 more
europepmc   +1 more source

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

open access: yesHeadache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1181-1192, May 2026.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source

Enhancing tomato regeneration and genetic transformation efficiencies via exogenous chemical treatment and the GRF5 gene modulation

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 5, Page 1268-1270, May 2026.
Supplementation of Driver and Kuniyuki Walnut Medium with phloroglucinol enhanced regeneration efficiency in tomato tissue culture. Heterologous expression of an Arabidopsis growth‐regulating factor gene, GROWTH‐REGULATING FACTOR5 (GRF5), in tomato improved regeneration and transformation efficiency, suggesting a synergistic effect between ...
Junjie Rong   +6 more
wiley   +1 more source

Stem Cells in Cosmetic Applications: Advancements, Challenges, and Future Directions

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Biotechnology has significantly impacted the cosmetics industry, particularly through the incorporation of plant stem cells, which possess regenerative properties beneficial for skincare. Aims This review aims to evaluate the potential benefits and challenges of using plant stem cells in cosmetics, while discussing future directions
Farid KarkonShayan   +4 more
wiley   +1 more source

Scaling law links plant growth variation to grain yield in wheat stands

open access: yesNew Phytologist, Volume 250, Issue 4, Page 2163-2175, May 2026.
Summary Growth rate, a fundamental trait associated with plant resource use, scales with plant mass, following consistent allometric power laws shaped by biophysical constraints and natural selection captured in metabolic scaling theory (MST). Although well‐established in wild plants, MST has been overlooked in crop improvement.
Guy Golan   +6 more
wiley   +1 more source

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