Results 61 to 70 of about 272,810 (306)

TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene

Nature Communications
Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the TADs boundaries do not always lead to significant changes in the activity ...
Evelyn Kabirova, Anastasiya Ryzhkova, Varvara Lukyanchikova, Anna Khabarova, Alexey Korablev, Tatyana Shnaider, Miroslav Nuriddinov, Polina Belokopytova, Alexander Smirnov, Nikita V. Khotskin, Galina Kontsevaya, Irina Serova, Nariman Battulin   +12 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

The Cytology of the Cladophoraceae

Annals of Botany, 1919
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +3 more sources

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

SEMG1/2 augment energy metabolism of tumor cells

Cell Death and Disease, 2020
SEMG1 and SEMG2 genes belong to the family of cancer-testis antigens (CTAs), whose expression normally is restricted to male germ cells but is often restored in various malignancies.
Oleg Shuvalov, Alyona Kizenko, Alexey Petukhov, Olga Fedorova, Alexandra Daks, Andrew Bottrill, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Nikolai Barlev   +8 more
doaj   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Olfactory transport efficiency of the amorphous and crystalline manganese oxide nanoparticles

Вавиловский журнал генетики и селекции, 2017
The ability to deliver particulated xenobiotics and therapeutic drugs directly from the nasal cavity to the central nervous system, bypassing the hemato-encephalic barrier, determines a high importance of investigation of factors influencing this process.
A. V. Romashchenko, D. V. Petrovskii, M. B.  Sharapova, Y. M. Moshkin, K. E. Kuper, K. N.  Morozova, E. V. Kiseleva, M. P. Moshkin   +7 more
doaj   +1 more source

[Performance by cytology and hybrid capture II in screening for high-grade squamous intraepithelial lesions in women with HIV]. [PDF]

, 2011
HIV-infected women are at increased risk of developing high-grade squamous intraepithelial lesions (HSIL), the precursor lesions for cervical cancer. This study estimated and compared the performance of cytology and hybrid capture II in screening for ...
Andrea Cytryn, Grinsztejn, Beatriz Gilda Jegerhorn, Russomano, Fábio Bastos, Letícia Martins Raposo, Cytryn, Andrea, Velasque, Luciane de Souza, Velasque, Luciane, Raposo, Let??cia Martins, Luz, Paula Mendes, Veloso, Valdil??a Gon??alves, Luciane Velasque, Santos, Valdiléa Gonçalves Veloso dos, Brasil, Pedro EAA, Pedro E. A. A. Brasil, Friedman, Ruth Khalili, Veloso, Valdiléa Gonçalves, Russomano, F??bio Bastos, Angela Cristina Vasconcelos de Andrade, Raposo, Letícia Martins, Vanni, Tazio, Russomano, Fabio, Beatriz Grinsztejn, Cytryn, Andr??a, Struchiner, Claudio José, Ruth Khalili Friedman, Andrade, Angela Cristina Vasconcelos de, Valdiléa Gonçalves Veloso, Claudio José Struchiner, Paula Mendes Luz, Grinsztejn, Beatriz, Fabio Russomano, Tazio Vanni, Brasil, Pedro E. A. A., Struchiner, Claudio Jos??   +33 more
core   +1 more source

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source