Results 1 to 10 of about 13,763 (258)

Combatting virulent gut bacteria by inhibiting the biosynthesis of a two-component lanthipeptide toxin [PDF]

Nature Communications
The enterococcal cytolysin is a toxic, two-component ribosomally synthesized and post-translationally modified peptide (RiPP) produced by pathogenic Enterococcus faecalis. Cytolysin-producing (C+) E.
Ryan Moreira, Bidisha Chakraborty, Yi Yang, Chandrashekhar Padhi, Michael S. Gilmore, Satish K. Nair, Wilfred A. van der Donk   +6 more
doaj   +2 more sources

Development of a Quantitative PCR Method for Detecting Enterococcus faecalis Cytolysin in Human Stool Samples [PDF]

Methods and Protocols, 2023
Alcohol-associated liver disease (ALD) is a major global health issue, contributing significantly to morbidity and mortality worldwide. Among the ALD subtypes, alcohol-associated hepatitis poses a severe and urgent medical challenge with high short-term ...
Noemí Cabré, Yongqiang Yang, Yanhan Wang, Bernd Schnabl   +3 more
doaj   +2 more sources

Enterococcus-derived cytolysin exacerbates ischemic stroke by disrupting the blood–brain barrier via NLRP3 activation [PDF]

Journal of Neuroinflammation
Background Ischemic stroke remains a major global health burden. Enterococcus, which is enriched in the gut of stroke patients, produces cytolysin—a pore-forming toxin that disrupts cell membranes.
Jia-ni Huang, Wei-hao Zhuang, Yi-si Lin, Jia-xue Xu, Yan-lei Zhang, Jia Li, Meng Huang, Cheng-long Xie, Ruo-ting Xu   +8 more
doaj   +2 more sources

The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins [PDF]

, 2016
The membrane attack complex and perforin proteins (MACPFs) and bacterial cholesterol-dependent cytolysins (CDCs) are two branches of a large and diverse superfamily of pore-forming proteins that function in immunity and pathogenesis.
Blackman, Bubeck, Bubeck, Cascales, Collier, Czajkowsky, Degiacomi, Dudkina, Dunstone, Estévez-Calvar, Ghatak, Giddings, Gilbert, Gilbert, Gilbert, Gilbert, Giousoh, Hadders, Hadders, Heuck, Hirst, Hotze, Hotze, Hotze, Housden, Jiang, Johnson, Johnson, Kawano, Kondos, LaChapelle, Law, Leka, Leung, Lovelace, Lukoyanova, Marchioretto, McCormack, Menestrina, Merle, Metkar, Morgan, Morgan, Mulvihill, Ounjai, Pardo-López, Peraro, Podack, Podobnik, Popoff, Praper, Ramachandran, Ramachandran, Ramm, Reboul, Reboul, Rosado, Rosado, Rossjohn, Sato, Serna, Seveau, Shatursky, Shepard, Shewell, Sonnen, Sugawara, Taylor, Tilley, Tomita, Tschopp, Tweten, Voskoboinik, Wade, Wade, Walker   +75 more
core   +4 more sources

Structure, Function, and Biology of the Enterococcus faecalis Cytolysin

Toxins, 2013
Enterococcus faecalis is a Gram-positive commensal member of the gut microbiota of a wide range of organisms. With the advent of antibiotic therapy, it has emerged as a multidrug resistant, hospital-acquired pathogen.
Daria Van Tyne, Michael S Gilmore
exaly   +3 more sources

Bacteria‐Elicited Specific Thrombosis Utilizing Acid‐Induced Cytolysin A Expression to Enable Potent Tumor Therapy

Advanced Science, 2022
Given the special microenvironment of solid tumors, live microorganisms have emerged as drug delivery vehicles and therapeutic agents. Here, an acid‐induced therapeutic platform is constructed using attenuated Escherichia coli to express the cytolysin A ...
Wen Song, Cheng Zhang
exaly   +2 more sources

Differential Endometrial Cell Sensitivity to a Cholesterol-Dependent Cytolysin Links Trueperella pyogenes to Uterine Disease in Cattle1 [PDF]

Biology of Reproduction, 2014
Purulent disease of the uterus develops in 40% of dairy cows after parturition, when the epithelium of the endometrium is disrupted to expose the underlying stroma to bacteria.
Gareth D Healey, Hans-Joachim Schuberth, David G E Smith   +2 more
exaly   +2 more sources

Granulocytes of sea anemone Actinia equina (Linnaeus, 1758) body fluid contain and release cytolysins forming plaques of lysis [PDF]

Invertebrate Survival Journal, 2014
The Cnidaria phylum includes organisms that are among the most poisonous animals. The exact composition of cnidarian bioactive molecules is not known in detail, but little is known on the cells that produce the toxins.
M G Parisi, M R Trapani, M Cammarata
doaj   +2 more sources

Comprehensive analysis of bacteriocins produced by clinical enterococcal isolates and their antibacterial activity against Enterococci including VRE [PDF]

Scientific Reports
It is well-known that Enterococcus species produce bacteriocins that have antibacterial activity. However, a comprehensive analysis of the bacteriocin distribution among Enterococcus strains has not been conducted.
Ayumi Fujii, Miki Kawada-Matsuo, Mi Nguyen-Tra Le, Yujin Suzuki, Saki Nishihama, Hideki Shiba, Tomonao Aikawa, Hitoshi Komatsuzawa   +7 more
doaj   +2 more sources

Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes [PDF]

, 2015
The virulence of many Gram-positive bacteria depends on cholesterol-dependent cytolysins (CDCs), which form pores in eukaryotic cell plasma membranes. Pyolysin (PLO) from Trueperella pyogenes provided a unique opportunity to explore cellular responses to
Duncan J. L., Giulio Preta, I. Martin Sheldon, James G. Cronin, Page B., Pavlovic D., Preta G., Triantafilou M., Virginia Lotti   +8 more
core   +3 more sources