Uncovering the potential virulence factors of emerging pathogens using AI/ML-based tools: a case study in Emergomyces africanus [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundWe are currently in the era of artificial intelligence (AI), which has become deeply embedded across nearly all scientific disciplines. Harnessing this revolutionary technology to predict virulence factors of emerging pathogens can improve our ...
Peter F. Farag +4 more
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Cytolysin A is an intracellularly induced and secreted cytotoxin of typhoidal Salmonella [PDF]
Nature CommunicationsTyphoidal Salmonella enterica serovars, such as Typhi and Paratyphi A, cause severe systemic infections, thereby posing a significant threat as human-adapted pathogens.
Lena Krone +2 more
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A Novel Biomimetic Nanosponge Protects the Retina from the Enterococcus faecalis Cytolysin [PDF]
MSphere, 2017 Liangfang Zhang
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Cytolysins Augment Superantigen Penetration of Stratified Mucosa [PDF]
The Journal of Immunology, 2009 Abstract Staphylococcus aureus and Streptococcus pyogenes colonize mucosal surfaces of the human body to cause disease. A group of virulence factors known as superantigens are produced by both of these organisms that allows them to cause serious diseases from the vaginal (staphylococci) or oral mucosa (streptococci) of the body ...
Amanda J. Brosnahan +4 more
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The hydrophobic character of thiol-activated cytolysins [PDF]
Biochemical Journal, 1982 Hydrophobic chromatography on phenyl–Sepharose has revealed the decidedly hydrophobic character of several members of the group of cytolytic proteins termed ‘thiol-activated’. Pneumolysin, alveolysin, cereolysin, and streptolysin O were found to be equally hydrophobic, as were the oxidized and reduced forms of alveolysin. Hydrophobic chromatography has
Mary K. Johnson +2 more
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Structural insights into Clostridium perfringens delta toxin pore formation [PDF]
, 2013 Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie +57 more
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Fish Cytolysins in All Their Complexity [PDF]
Toxins, 2021 The majority of the effects observed upon envenomation by scorpaenoid fish species can be reproduced by the cytolysins present in their venoms. Fish cytolysins are multifunctional proteins that elicit lethal, cytolytic, cardiovascular, inflammatory, nociceptive, and neuromuscular activities, representing a novel class of protein toxins.
Fabiana V. Campos +3 more
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Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly [PDF]
Nature Communications, 2016 Marjetka Podobnik +2 more
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Hepatology, EarlyView., 2022 In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole +12 more
wiley +1 more source
DIFFERENCES IN GENOTYPE OF E. FAECALIS AND E. FAECIUM CLINICAL ISOLATES REGARDING CYTOLYSIN AND GELATINASE PRODUCTION IN BULGARIAN PATIENTS [PDF]
Trakia Journal of Sciences, 2020 Purpose - compare the phenotype and genotype correlation of cytolysin and gelatinase production in clinical isolates Enterococcus spp. Materials and methods - 100 Enterococcus strains collected over a period of one year from inpatients of two Bulgarian ...
R. Yordanova, S. Stanilova
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