Results 31 to 40 of about 13,763 (258)
Structural basis of complement membrane attack complex formation [PDF]
, 2015 In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit’ mechanism; however, sublytic MAC pores on host cells activate ...
Bubeck, D +3 more
core +1 more source
A Novel Biomimetic Nanosponge Protects the Retina from the
mSphere, 2017 Intraocular infections are a potentially blinding complication of common ocular surgeries and traumatic eye injuries. Bacterial toxins synthesized in the eye can damage intraocular tissue, often resulting in poor visual outcomes.
Austin L. LaGrow +8 more
doaj +1 more source
Frontiers in Immunology, 2022 In contrast to the virulent human skin commensal Staphylococcus aureus, which secretes a plethora of toxins, other staphylococci have much reduced virulence. In these species, commonly the only toxins are those of the phenol-soluble modulin (PSM) family.
Kunal Reshamwala +11 more
doaj +1 more source
Substrate control in stereoselective lanthionine biosynthesis. [PDF]
, 2015 Enzymes are typically highly stereoselective catalysts that enforce a reactive conformation on their native substrates. We report here a rare example in which the substrate controls the stereoselectivity of an enzyme-catalysed Michael-type addition ...
Houk, KN +3 more
core +2 more sources
Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes [PDF]
, 2008 peer-reviewedStreptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal
Casey, Patrick G. +7 more
core +4 more sources
Antigenic relationships among thiol-activated cytolysins [PDF]
Infection and Immunity, 1977 Cereolysin, streptolysin O, and perfringolysin O formed precipitin lines that completely fused when reacted with horse antitetanolysin by Ouchterlony immunodiffusion and formed precipitin lines that showed either partial or complete fusion when diffused against horse antistreptolysin O or antiperfringolysin O.
J L, Cowell, A W, Bernheimer
openaire +2 more sources
Mutagenesis and Functional Analysis of the Pore-Forming Toxin HALT-1 from Hydra magnipapillata
Toxins, 2015 Actinoporins are small 18.5 kDa pore-forming toxins. A family of six actinoporin genes has been identified in the genome of Hydra magnipapillata, and HALT-1 (Hydra actinoporin-like toxin-1) has been shown to have haemolytic activity.
Yvonne Jing Mei Liew +3 more
doaj +1 more source
Cytotoxicity of the Bacillus thuringiensis Crystal Protein against Mammalian Cells [PDF]
, 2002 The crystal proteins produced by Bacillus thuringiensis subsp, israelensis (Bti) and subsp. coreanensis A1519 strain were examined for the cytotoxicity against MOLT-4 and HeLa cells by MTT assay and LDH assay, The A1519 crystal proteins processed by ...
Akao, Tetsuyuki +5 more
core +1 more source
Cytolysin-dependent evasion of lysosomal killing [PDF]
Proceedings of the National Academy of Sciences, 2005 Local host defenses limit proliferation and systemic spread of pathogenic bacteria from sites of mucosal colonization. For pathogens such as streptococci that fail to grow intracellularly, internalization and killing by epithelial cells contribute to the control of bacterial growth and dissemination.
Anders, Håkansson +3 more
openaire +2 more sources
Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue [PDF]
, 2011 Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations.
Asparouh I. Iliev +40 more
core +3 more sources