Results 51 to 60 of about 13,763 (258)
SpxA1 and SpxA2 act coordinately to fine-tune stress responses and virulence in Streptococcus pyogenes [PDF]
, 2017 SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood.
Gary C. Port +4 more
core +4 more sources
Alcohol-Related Liver Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions. [PDF]
MedComm (2020)Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Tan Y, Hu Y, Yang Y, Chu H.
europepmc +2 more sources
Purification and characterization of Vibrio metschnikovii cytolysin [PDF]
Infection and Immunity, 1988 An extracellular cytolysin produced by Vibrio metschnikovii was purified by acid precipitation, phenyl-Sepharose CL-4B chromatography, and rechromatography on a phenyl-Sepharose CL-4B column and high-performance liquid chromatography on a Mono Q (anion-exchange) column. The purified cytolysin had a molecular weight of 50,000 and an isoelectric point of
M, Miyake, T, Honda, T, Miwatani
openaire +2 more sources
Journal of Clinical and Biomedical SciencesA protein called cytolysin A or ClyA, encoded by certain bacteria species, can cause cytotoxicity. Although the ClyA protein is not typically expressed at detectable levels in most E.
Seyedeh Maryam Mousavi +5 more
doaj +1 more source
Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. [PDF]
, 2019 Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of ...
Fong, Loren G +11 more
core +3 more sources
Synergistic action of actinoporin isoforms from the same sea anemone species assembled into functionally active heteropores [PDF]
, 2016 Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are pore forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multigene families
Alegre Cebollada, Jorge +5 more
core +5 more sources
Journal of Venomous Animals and Toxins including Tropical Diseases, 2012 Although sea anemones are well known for being rich sources of toxins, including cytolysins and neurotoxins, their venoms and toxins have been poorly studied.
M Ramezanpour +2 more
doaj +1 more source
Microorganisms, 2022 Necrotizing soft tissue infections caused by Streptococcus pyogenes (group A streptococcus [GAS]) are characterized by rapid and extensive necrosis of fascia and muscle.
Eric R. McIndoo +7 more
doaj +1 more source
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin [PDF]
, 2014 Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors and effectors in immune defence.
Baker +42 more
core +3 more sources
, 2015 Bacteriocins are peptide-derived molecules produced by bacteria, whose recently-discovered functions include virulence factors and signalling molecules as well as their better known roles as antibiotics.
Freed, Stefan D +3 more
core +1 more source