Results 61 to 70 of about 13,763 (258)

Conformational changes during pore formation by the perforin-related protein pleurotolysin [PDF]

, 2015
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis.
AE Aleshin, AE Aleshin, AG Murzin, AJ Farrand, AP Pandurangan, BF Kafsack, Bradley A. Spicer, C Morita-Yamamuro, C Zheng, CF Reboul, CJ Rosado, CL Birmingham, Cyril F. Reboul, D Meusch, D Vasishtan, Daouda A. K. Traore, DH Lockert, DJ Slade, DM Czajkowsky, DW Schuerch, EF Pettersen, Eileen M. Hotze, EM Hotze, EM Hotze, H Unno, Helen R. Saibil, I Iacovache, Ilia Voskoboinik, Irene Farabella, J Rossjohn, J Tschopp, James C. Whisstock, JM Mancheno, Joseph A. Trapani, K Kadota, K Ota, Katherine Oliver, LA Shepard, LL Lovelace, LM Stevens, M Topf, MA Hadders, MA Hadders, MA Henstridge, Maya Topf, Michelle A. Dunstone, MT Degiacomi, MY Shen, N Sakurai, Natalya Lukoyanova, O Shatursky, Oded Kleifeld, R Ramachandran, R Ramachandran, Raimund Dutzler, RH Law, Rodney K. Tweten, Ruby H. P. Law, SJ Tilley, Stephanie C. Kondos, Susan M. Ekkel, T Tomita, Tamas Hatfaludi, Tom T. Caradoc-Davies   +63 more
core   +3 more sources

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]

, 2017
Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias, Mukherjee, Shaeri, Schlaermann, Philipp   +2 more
core   +2 more sources

Intracellular self‐assembled nanoneedles for efficient lysosomal escape and CRISPR/Cas9 mediated gene editing

BMEMat, EarlyView.
PlaMnB was formed by cytolysin A‐tumor homing peptides (THP)‐modified bacterial membranes encapsulating the clustered regularly interspaced short palindromic repeat/CRISPR‐associated protein (CRISPR/Cas9) plasmid and manganese dioxide. THP‐containing bacterial membrane enhances PlaMnB vascular permeability and tumor targeting, and after cellular ...
Chen Zhang, Nan Zhang, Ruiqi Yang, Qian Qiu, Jiaying Huang, Jingang Liu, Silu Li, Jonathan F. Lovell, He Ren, Yumiao Zhang   +9 more
wiley   +1 more source

Channel Formation by LktA of Mannheimia (Pasteurella) haemolytica in Lipid Bilayer Membranes and Comparison of Channel Properties with Other RTX-Cytolysins

Toxins, 2019
Cytolysin LktA is one of the major pathogenicity factors of Mannheimia haemolytica (formerly Pasteurella haemolytica) that is the cause of pasteurellosis, also known as shipping fever pneumonia, causing substantial loss of sheep and cattle during ...
Roland Benz, Claudio Piselli, Andrew A. Potter   +2 more
doaj   +1 more source

Listeriolysin O is necessary and sufficient to induce autophagy during Listeria monocytogenes infection. [PDF]

PLoS ONE, 2010
Recent studies have suggested that autophagy is utilized by cells as a protective mechanism against Listeria monocytogenes infection.However we find autophagy has no measurable role in vacuolar escape and intracellular growth in primary cultured bone ...
Nicole Meyer-Morse, Jennifer R Robbins, Chris S Rae, Sofia N Mochegova, Michele S Swanson, Zijiang Zhao, Herbert W Virgin, Daniel Portnoy   +7 more
doaj   +1 more source

Membrane-translocating peptides and toxins: from nature to bedside [PDF]

, 2008
Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for ...
Hayashi, Mirian Akemi Furuie, Kerkis, Alexandre, Kerkis, Irina, Prieto-Silva, Álvaro Rossan, Rádis-Baptista, Gandhi, Tetsuo, Yamane   +5 more
core   +1 more source

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Complete genome sequences of emm6 Streptococcus pyogenes JRS4 and parental strain D471 [PDF]

, 2015
We report the complete genome assemblies of the group A Streptococcus pyogenes serotype emm6 strain D471 and its streptomycin-resistant derivative JRS4. Both of these well-studied laboratory strains have been extensively characterized over the past three
Caparon, Michael G, Paluscio, Elyse, Port, Gary C   +2 more
core   +2 more sources

Characterization, purification and phylogenetic analysis of a cytolysin from the sea anemone Heteractis magnifica of the Indian Ocean

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
It is well established that sea anemones comprise a rich source of cytolytic toxins. The present study reports the isolation and characterization of a cytolysin obtained from the sea anemone Heteractis magnifica collected in the Andaman Islands of the ...
S Karthikayalu, V Rama, R Kirubagaran, R Venkatesan   +3 more
doaj   +1 more source