Results 161 to 170 of about 309,825 (296)

Natural killer cells as an initial defense against pathogens. [PDF]

, 2006
Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse range of pathogens. Recognition of infection by NK cells is accomplished by the activation of receptors on the NK cell surface, which initiate NK cell ...
Lanier, Lewis L, Lodoen, Melissa B
core  

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Electron Microscopic Studies of Human Cytomegalovirus.-Characterization of Intracellular Forms of Parental Viral DNA Molecules before and after Onset of the Viral DNA Synthesis

, 1982
N Yoshimura
openalex   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Disseminated Cytomegalovirus Infection in a Patient with RAG2 Mutation SCID Transmitted via Breast Feeding: A Case Report and Review of Literature

, 2019
Asma Danish, Samreen Kulsoom, Saqib Hussain Ansari, Tahir Shamsi   +3 more
openalex   +1 more source

Severe Influenza Pneumonia and Cytomegalovirus Co-Infection Manifested with Hemophagocytic Histiocytosis and Respiratory Distress Syndrome [PDF]

, 2020
Saiping Huang
openalex   +1 more source

1048. Double-Blind, Randomized, Placebo-Controlled Phase 2b Multicenter Trial of V160, a Replication-Defective Human Cytomegalovirus (CMV) Vaccine [PDF]

, 2021
Rituparna Das, Daniel Blázquez‐Gamero, David I. Bernstein, Soren Gantt, Oliver Bautista, Karen Beck, Anthony Conlon, Daniel I. S. Rosenbloom, Dai Wang, Michael Ritter, Beth Arnold, Paula W. Annunziato, Kevin L. Russell   +12 more
openalex   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Cytomegalovirus-induced mononucleosis in guinea pigs [PDF]

, 1981
Brigitte P. Griffith, H. L. Lucia, Frank J. Bia, G. D. Hsiung   +3 more
openalex   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source