Results 191 to 200 of about 179,487 (293)

Expert Perspective: Diagnosis and Treatment of Castleman Disease

open access: yesArthritis &Rheumatology, Accepted Article.
Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen   +2 more
wiley   +1 more source

A tolerogenic plasmid inhibits autoantibody production triggered by immunization with human peptidyl arginine deiminase 4.

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs).
Philippe P. Pagni   +10 more
wiley   +1 more source

Autoantibody response towards chromatin in patients with juvenile idiopathic arthritis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Juvenile idiopathic arthritis (JIA) patients frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in JIA patients remains elusive. Methods Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with ...
Viola Pitkänen   +13 more
wiley   +1 more source

Enrichment of Full AAV2 Using Multicolumn Countercurrent Solvent Gradient Purification (MCSGP)

open access: yesBiotechnology and Bioengineering, EarlyView.
The multicolumn countercurrent solvent gradient purification (MCSGP) method was evaluated as a method to enhance the separation of empty and full capsids during AAV2 purification. The results demonstrated an enrichment of full AAV2 particles using MCSGP.
Julia M. Müller   +9 more
wiley   +1 more source

Eye on cytomegalovirus: Unveiling the ophthalmic impact of cytomegalovirus. [PDF]

open access: yesWorld J Virol
Musa M   +7 more
europepmc   +1 more source

Leveraging Digital Intelligence Technologies for Green Shipping: Organization Information Processing and Contingency Perspective

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study investigates how digital intelligence technology applications (DITAs) enhance green shipping management performance (GSMP) by improving organizational capabilities in the face of environmental uncertainty. Drawing on organizational information processing theory and contingency theory, we develop a framework that examines the ...
Qiwei Pang, Xin Liu, Miao Su
wiley   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

open access: yesCancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu   +12 more
wiley   +1 more source

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