Results 141 to 150 of about 101,747 (197)

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Clinical Characteristics, Neuroimaging Findings and Long-Term Sequelae in Children with Congenital Cytomegalovirus Infection: A Single Centre Study. [PDF]

Pathogens
Valenčak I, Stemberger Marić L, Vrdoljak Pažur M, Židovec Lepej S, Šuvak N, Tešović G.   +5 more
europepmc   +1 more source

The S‐Phase Arrest of Host Cells Caused by an Alpha‐Herpesvirus Genome Replication Facilitates Viral Recruitment of RNA Polymerase II to Transcribe Viral Genes

Cell Proliferation, EarlyView.
Viral infection arrests host cells in the S phase, which promotes vDNA synthesis and vRC formation, further facilitating viral recruitment of RNA Pol II to preferentially transcribe viral genes. ABSTRACT Herpesviruses rely on host RNA polymerae II (RNA Pol II) for their mRNA transcription, yet the mechanisms of which has been poorly defined, while ...
Qiqi Yang, Ying Wu, Mingshu Wang, Shun Chen, Renyong Jia, Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng   +16 more
wiley   +1 more source

The Angiogenic Markers PlGF and sFlt-1 in Cytomegalovirus Infection During Pregnancy: Insights from a Clinical Case. [PDF]

Viruses
Giardini V, Chiozzi R, Fernicola F, Casati M, Locatelli A, Ornaghi S.   +5 more
europepmc   +1 more source

Real‐world outcomes of vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome at a tertiary referral centre

British Journal of Haematology, EarlyView.
Lucia Lee, Eric J. Zhao, Robert Schmidt, Alym Abdulla, Gayatri Sreenivasan, Kimberley Ambler, Megan Hiltz, Lynda Foltz, Vicki Chan, Alexandra Legge, Maggie Yuen, Lauren Lee, Paul Yenson, Thomas J. Nevill, Luke Y. C. Chen, Ryan J. Stubbins   +15 more
wiley   +1 more source

PD‐L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC‐RPE Grafts in Retinal Degeneration

Cell Proliferation, EarlyView.
We generated immune‐tolerant mature hESC‐RPE cells by overexpressing PD‐L1. PD‐L1‐expressing hESC‐RPE grafts exhibited significantly higher survival, reduced apoptosis and enhanced visual protection in retinal degeneration models, which presents an alternative target to improve the efficiency of hESC‐RPE‐based therapy for AMD. ABSTRACT Immune rejection
Bowen Li, Xue Zhang, Yajie Fang, Min Chen, Qiyou Li, Yuxiao Zeng, Chunge Ren, Chengang Wang, Yingxue Lv, Jia Lu, Hongling Liu, Yong Liu   +11 more
wiley   +1 more source

Modulation of Monocyte Effector Functions and Gene Expression by Human Cytomegalovirus Infection. [PDF]

Viruses
Planchon MS, Fishman JA, El Khoury J.
europepmc   +1 more source

Stroke‐Homing Peptide‐DNase1 Alleviates Intestinal Ischemia Reperfusion Injury by Selectively Degrading Neutrophil Extracellular Traps

Cell Proliferation, EarlyView.
SHp‐DNase1 combined with CRO inhibits NETs to alleviate intestinal IRI ABSTRACT Neutrophil extracellular traps (NETs) act as a vital first line of defence against tissue damage and pathogens, playing a significant role in improving diseases such as intestinal ischemia reperfusion injury (IRI).
Tingting Liu, Xinrong Lv, Qingshan Xu, Xiuting Qi, Shenghui Qiu, Yaqi Luan, Na Shen, Jing Cheng, Lan Jin, Tian Tian, Wentao Liu, Lai Jin, Zhongzhi Jia   +12 more
wiley   +1 more source

¹H NMR Urinary Metabolomics Profiling of Newborns with Congenital Human Cytomegalovirus Infection: Insights into Metabolic Alterations. [PDF]

J Proteome Res
Spadavecchia A, Zoccarato M, Tedone G, Biolatti M, Dell'Oste V, Leone A, Cossard A, Sozzi M, Bresesti I, Bertino E, Gobetto R, Coscia A, Gallo A.   +12 more
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source