Results 201 to 210 of about 121,324 (293)
Targeting KDM1A suppresses G6PD expression to induce oxidative stress and ferroptosis in TP53‐mutated liver cancer
VIEW, EarlyView.TP53‐mutant HCC is aggressive and often resistant to treatment. In this study, we found that KDM1A is highly expressed in TP53‐mutant HCC and promotes tumor growth while preventing ferroptosis by activating the pentose phosphate pathway (PPP). Targeting KDM1A, especially in combination with sorafenib, may offer a promising therapeutic strategy for this Songling Li, Wenyun Guo, Yifei Qian, Linfeng Li, Qianyu Li, Zijun Zhu, Wenli Qin, Wang Li, Yunfeng Yuan, Wei‐Qiang Gao, Yanfeng Liu +10 morewiley +1 more sourceChinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT
Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association; Society of Audiology and Vestibular Medicine, China International Exchange and Promotive Association for Medical and Health Care, Hong‐Yang Wang, Guo‐Hui Nie, Xiao‐Nan Wu, Ding‐Jun Zha, Tao Shi, Hai‐Bo Shi, Yong Feng, Wen‐Yan Li, Hai‐Hong Liu, Qing Zhang, Xiao‐Wei Chen, Xia Gao, Yong‐Xin Li, Lu Ma, Jin Li, Dan‐Yang Li, Xiao‐Long Zhang, Meng‐Tao Song, Xin Zhou, Lan Lan, Lan Yu, Meng‐Qian Zhang, Wei Shi, Fen Xiong, Lin‐Yi Xie, Guo‐Hui Chen, Kai‐Li Wu, Xiao‐Qian Ren, Qiu‐Jing Zhang, Ming‐Hui Zhao, Zi‐Yi Chen, Fei Ji, Jiao Zhang, Jing Guan, Da‐Yong Wang, Ren‐Jie Chai, Xin Jin, Hua‐Wei Li, Shi‐Ming Yang, Shan‐Kai Yin, Qiu‐Ju Wang +43 morewiley +1 more sourceThe 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Aging Cell, EarlyView.Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond Muthu Saravanan Manoharan, Grace C. Lee, Nathan Harper, Justin A. Meunier, Marcos I. Restrepo, Fabio Jimenez, Sreenath Karekatt, Anne P. Branum, Alvaro A. Gaitan, Kian Andampour, Alisha M. Smith, Michael Mader, Michelle Noronha, Devjit Tripathy, Nu Zhang, Alvaro G. Moreira, Lavanya Pandranki, South Texas Veterans Health Care System (STVHCS) COVID‐19 Clinical team, STVHCS COVID‐19 Vaccine team, STVHCS COVID‐19 Convalescent care team, STVHCS Center for Personalized Medicine, Sandra Sanchez‐Reilly, Hanh D. Trinh, Clea Barnett, Luis Angel, Leopoldo N. Segal, Susannah Nicholson, Robert A. Clark, Weijing He, Jason F. Okulicz, Sunil K. Ahuja, Andrew Carrillo, Chanda Dhami, Gaeun Jo, Krupa Jiva, Ernesto Robinson, Caitlyn A. Winter, Lauryn A. Winter, Erin Stewart, Joseph M. Yabes, Peter Melby, Cody R. Butler, Mohamed I. Abdalla, Sandra G. Adams, Yemi Adebayo, Joseph Agnew, Saleem Ali, Gregory Anstead, Antonio Anzueto, Marichu Balmes, Jennifer Barker, Raymond Benavides, Velma Bible, Angela Birdwell, Stacy Braddy, Stephen Bradford, Heather Briggs, Jose A. Cadena Zuluaga, Judith Marin‐Corral, Jennifer J. Dacus, Patrick J. Danaher, Scott A. DePaul, Jill Dickerson, Jollynn Doanne, Samantha Elbel, Miguel Escalante, Corina Escamilla, Valerie Escamilla, Robert Farrar, David Feldman, Debra Flores, Julianne Flynn, Delvina Ford, Joanna D. Foy, Megan Freeman, Samantha Galley, Jessica Garcia, Maritza Garza, Sherraine Gilman, Melanie Goel, Jennifer Gomez, Varun K. Goyal, Sally Grassmuck, Susan Grigsby, Joshua Hanson, Brande Harris, Audrey Haywood, Joan M. Hecht, Cecilia Hinojosa, Tony T. Ho, Teri Hopkins, Aneela N. Hussain, Ali Jabur, Pamela Jewell, Thomas B. Johnson, Austin C. Lawler, Monica Lee, Chadwick S. Lester, Stephanie M. Levine, Haidee V. Lewis, Angel Louder, Charmaine Mainor, Rachel Maldonado, Celida Martinez, Yvette Martinez, Chloe Mata, Neil McElligott, Laura Medlin, Myra Mireles, Joanna Moreno, Kathleen Morneau, Julie Muetz, Samuel B. Munro, Charlotte Murray, Anoop Nambiar, Daniel Nassery, Robert Nathanson, Kimberly Oakman, Jane O’Rorke, Cheryl Padgett, Sergi Pascual‐Guardia, Marisa Patterson, Graciela L. Perez, Rogelio Perez, Jay I. Peters, Rogelio Perez III, Robert E. Phillips, Patrick B. Polk, Michael A. Pomager, Kristy J. Preston, Kevin C. Proud, Jacqueline A. Pugh, Michelle Rangel, Temple A. Ratcliffe, Renee L. Reichelderfer, Evan M. Renz, Jeanette Ross, Teresa Rudd, Maria E. Sanchez, Tammy Sanders, Kevin C. Schindler, David Schmit, Raj T. Sehgal, Claudio Solorzano, Nilam Soni, Win S. Tam, Edward J. Tovar, Sadie A. Trammell Velasquez, Anna R. Tyler, Anjuli Vasquez, Maria C. Veloso, Steven G. Venticinque, Jorge A. Villalpando, Melissa Villanueva, Lauren Villegas, Megan Walker, Andrew Wallace, Maria Wallace, Emily Wang, Stephanie Wickizer, Andreia Williamson, Andrea Yunes, Katharine H. Zentner, Azaneth Arellanes, Ashley B. Banfield, Stephanie N. Bolan‐Reding, Roxanne Colazo, Katherine S. DeLeon, Norma G. Diaz, Mario A. Garza, Raed Kadhume, Hue Mang, Erwin Paleracio, Robert F. Quitta, Laura J. Ramirez, Marzieh Salehi, Cynthia J. Varela +176 morewiley +1 more source