Results 51 to 60 of about 4,161 (148)

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Comparing VIP and PD‐L1 expression as cancer biomarkers

ImmunoMedicine, Volume 2, Issue 2, December 2022., 2022
Abstract Immune checkpoint molecules are critical targets of cancer therapies due to their ability to modulate immune responses to cancer. Vasoactive intestinal peptide (VIP) has been proposed as an immune checkpoint molecule, but its predictive and prognostic values have not been established.
Jojo Y. Liu, Hanwen Zhang, Sruthi Ravindranathan, Taofeek K. Owonikoko, Bassel F. El‐Rayes, Yuan Liu, Edmund K. Waller   +6 more
wiley   +1 more source

Targeted preemptive therapy according to perceived risk of CMV infection after kidney transplantation

Brazilian Journal of Infectious Diseases, 2016
Background: The identification of the best strategy to manage cytomegalovirus infection is hampered by uncertainties regarding the risk/benefit ratios of universal prophylaxis versus preemptive therapy, the impact of indirect cytomegalovirus effects and ...
Cahue Henrique Pinto, Helio Tedesco-Silva Jr, Claudia Rosso Felipe, Alexandra Nicolau Ferreira, Marina Cristelli, Laila Almeida Viana, Wilson Aguiar, José Medina-Pestana   +7 more
doaj  

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Maribavir Pharmacokinetics and Safety in Participants With Moderate Hepatic Impairment: A Phase 1, Open‐Label, Single‐Dose, Parallel Group Study

The Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 250-258, February 2023., 2023
Abstract Maribavir, an orally bioavailable antiviral, has shown superior activity against posttransplant cytomegalovirus infection compared with conventional antivirals. It is primarily metabolized in the liver. This open‐label, single‐center study evaluated the effect of hepatic impairment on the pharmacokinetics of maribavir in nontransplant ...
Ivy Song, Grace Chen, Jingyang Wu, Katarina Ilic   +3 more
wiley   +1 more source

The role of cytomegalovirus in the development of opportunistic infections [PDF]

The Moldovan Medical Journal, 2019
Background: About one century ago, was found and described a new virus, which, due to its particular way of damaging cells, was called cytomegalovirus. Human is the only natural source of cytomegalovirus infection.
Elena Cirjau, Emilia Behta
doaj   +1 more source

Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single‐Cell Secretory and Intracellular Dynamics

Advanced Science, EarlyView.
This study leverages the complementary advantages of label‐free nanoplasmonic biosensing and multichannel fluorescence microscopy to develop a multimodal imaging system for real‐time, spatiotemporal monitoring of cellular activities at the single‐cell level.
Saeid Ansaryan, Yung‐Cheng Chiang, Yen‐Cheng Liu, Patrick Reichenbach, Melita Irving, Hatice Altug   +5 more
wiley   +1 more source

Chronic steroid use: An overlooked impact on patients with inflammatory bowel disease

JGH Open, Volume 6, Issue 12, Page 910-914, December 2022., 2022
Steroids have long been used in inducing remission of inflammatory bowel disease (IBD), but there is controversy about whether IBD patients should be on chronic steroids for maintenance therapy. In this retrospective study, we aim to identify the complications of chronic steroid use in patients with IBD.
Kristen L Farraj, James R Pellegrini, Rezwan F Munshi, Jose Russe‐Russe, Aboud Kaliounji, Muhammad S Tiwana, Pranay Srivastava, Krishnayer Subramani   +7 more
wiley   +1 more source

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

Advanced Science, EarlyView.
Network‐based risk stratification of people living with HIV (PWH) on prolonged therapy using multi‐omics data identifies 44% of the patients are at risk of immunometabolic complications. A senescence‐associated myeloid cell‐driven plasma microenvironment drives immunometabolic dysregulation in at‐risk PWH.
Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro de Magalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi   +32 more
wiley   +1 more source

Resistant cytomegalovirus infection in renal transplant recipients

Proceedings of Singapore Healthcare, 2015
Resistant cytomegalovirus infection is a significant problem in the transplant population including renal transplant recipients. A combination of factors including receipt of potent immunosuppression, high viral loads and suboptimal levels of anti ...
Benjamin Pei Zhi Cherng, Thuan Tong Tan, Ban Hock Tan   +2 more
doaj   +1 more source