Results 91 to 100 of about 953,563 (287)

Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye.

PLoS Pathogens, 2018
Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like the eye, including the neural retina, which have been considered immune privileged.
Valentina Voigt, Christopher E Andoniou, Iona S Schuster, Anna Oszmiana, Monique L Ong, Peter Fleming, John V Forrester, Mariapia A Degli-Esposti   +7 more
doaj   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Ultrasound indications for maternal STORCH testing in pregnancy

Swiss Medical Weekly, 2017
AIMS OF THE STUDY Fetal abnormalities found on ultrasonography lead to a variety of diagnostic procedures, including a panel of serologies to detect possible maternal STORCH infections encompassing syphilis, Toxoplasma gondii, rubella ...
Cora Alexandra Voekt, Therese Rinderknecht, Hans Hirsch, Annette Blaich, Irene Mathilde Hösli   +4 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Additional risk factors of ventricular repolarization asynchrony in Q-wave myocardial infarction

Российский кардиологический журнал, 2007
The study included 101 patients with acute Q-wave infarction. Standard examination was accompanied by assessment of myocardial repolarization dispersion assessment (Day 1 and Day 7) and Chlamydia pneumoniae and Cytomegalovirus infections.
L. E. Lagunina, E. A. Fedotov, Yu. G. Shwartz   +2 more
doaj  

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Host immune response to cytomegalovirus [PDF]

, 1987
To confirm that immediate-early (IE) genes of murine cytomegalovirus (MCMV) give rise to antigens recognized by specific cytolytic T lymphocytes (CTL), a 10.8-kilobase fragment of MCMV DNA which is abundantly transcribed at IE times was transfected into ...
Reddehase, Matthias J., Koszinowski, Ulrich H., Schickedanz, Jörg, Keil, Günther M.   +3 more
core   +1 more source

Cytomegalovirus infection with lissencephaly

Indian Journal of Pathology and Microbiology, 2008
Lissencephaly is a malformation of the brain in which the brain surface is smooth, rather than convoluted. Among the various causes of lissencephaly, infection by a virus during pregnancy plays an important role. Cytomegalovirus (CMV) is an important pathogen causing this anomaly.
Joseph Leena, Pushpalatha, Kuruvilla Sarah   +2 more
openaire   +3 more sources

Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis [PDF]

, 2001
Background—Studies have suggested that the prevalence of antibodies against heat-shock proteins (HSPs), Chlamydia pneumoniae (Cpn), and cytomegalovirus (CMV) is associated with coronary artery disease (CAD), but the independent or joint effects of ...
Virók Dezső, Gönczöl Éva, Prohászka Zoltán, Burián, Katalin, Endrész Valéria, Duba Jenő, Füst György, Kis, Zoltán, Virók, Dezső, Endrész, Valéria, Duba, Jenő, Boda, Krisztina, Berencsi Klára, Berencsi, Klára, Kis Zoltán, Romics, László, Romics László, Gönczöl, Éva, Prohászka, Zoltán, Horváth, Laura, Boda Krisztina, Burián Katalin, Horváth Laura, Füst, György   +23 more
core   +1 more source