Results 291 to 300 of about 3,451,157 (398)
Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis
Cancer Science, EarlyView.Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu +6 morewiley +1 more sourceDysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury
Cell Proliferation, EarlyView.Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT
Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu +15 morewiley +1 more sourceIntestinal and multiple organ transplantation [PDF]
, 1995 Abu-Elmagd, K, Casavilla, A, Reyes, J, Selby, R, Starzl, TE, Todo, S, Tzakis, A +6 morecore Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues
Cell Proliferation, EarlyView.H1N1 infection during pregnancy specifically targets the fetal liver and lungs, triggering immune responses, tissue fibrosis and ferroptosis in parenchymal cells, ultimately leading to adverse pregnancy outcomes, offering insights into managing maternal H1N1 infections and their impact on fetal health.Yuxi Jiang, Yao Shen, Qiongyin Zhang, Zi Liu, Yuzhen Liu, Jiaojiao Peng, Xuesong Yang, Feng Gao, Xiang‐Hong Ou, Qing‐Yuan Sun, Qiao Zhang, Guang Wang +11 morewiley +1 more sourceVenetoclax plus hypomethylating agents as effective bridge therapy to allogeneic stem cell transplant in relapsed/refractory acute myeloid leukaemia: A subanalysis of the AVALON study
British Journal of Haematology, EarlyView.Elisabetta Petracci, Francesca Pavesi, Luca Castagna, Patrizia Zappasodi, Cristina Papayannidis, Calogero Vetro, Vincenzo Federico, Alessandro Cignetti, Erika Borlenghi, Nicola Fracchiolla, Luca Facchini, Luca Maurillo, Ernesta Audisio, Massimo Bernardi, Felicetto Ferrara, Francesco Lanza, Carmine Selleri, Ilenia Manfra, Claudio Cerchione, Jacopo Nanni, Andrea Davide Romagnoli, Giovanni Marconi, Chiara Zingaretti, Ivana Lotesoriere, Federica Gigli, Giovanni Martinelli, Elisabetta Todisco +26 morewiley +1 more sourceIdentification and Phylogenetic Characterisation of Novel Adeno‐Associated Virus Capsids in Non‐Human Primate Tissues
Cell Proliferation, EarlyView.AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...Liyu Zhu, Kai Xu, Yali Ding, Kailun Liu, Jing Liu, Zongren Hou, Rui Niu, Ning Yang, Hualing Qin, Baoyang Hu, Ying Zhang, Wei Li +11 morewiley +1 more sourceHumoral and functional SARS‐CoV‐2‐specific T‐cell responses elicited in chronic lymphocytic leukaemia patients with GEO‐CM04S1 a synthetic MVA‐vectored COVID‐19 vaccine
British Journal of Haematology, EarlyView.Sandra Ortega‐Francisco, Maria Teresa Prudente de Aquino, Corinna La Rosa, Flavia Chiuppesi, Miguel‐Angel Gutierrez, Jacqueline Miller, Jing Li, Jada Mack‐Onyeike, Yifei Zhou, Qiao Zhou, Teodora Kaltcheva, Angela Patterson, Shannon Dempsey, Sandra Thomas, Katrin Tiemann, Dongyun Yang, Wasima Rida, Felix Wussow, Kelly McKee, Randy Taplitz, Erica Raiden, Tanya Siddiqi, Steven Rosen, Don J. Diamond, Alexey Danilov +24 morewiley +1 more sourceGuidance of ganciclovir therapy with pp65 antigenemia in cytomegalovirus-free recipients of livers from seropositive donors [PDF]
, 1996 Fung, J, Grossi, P, Kusne, S, Magnone, M, Rakela, J, Rinaldo, C, St. George, K, Starzl, TE +7 morecore
