Results 91 to 100 of about 615,339 (319)
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 The P2X4 channel is involved in different physiological and pathological conditions and functions in the nervous system. Despite the existence of several mouse models for which the expression of the gene was manipulated, there is still little information
Philine Bergmann +12 more
doaj +1 more source
An Algorithmic Pipeline for Analyzing Multi-parametric Flow Cytometry Data [PDF]
arXiv, 2015 Flow cytometry (FC) is a single-cell profiling platform for measuring the phenotypes of individual cells from millions of cells in biological samples. FC employs high-throughput technologies and generates high-dimensional data, and hence algorithms for analyzing the data represent a bottleneck.
arxiv
Cold Spring Harbor Protocols, 2011 INTRODUCTIONThis protocol provides the general steps for magnetic twisting cytometry (MTC). MTC is an active microrheology method well-suited to measuring the mechanical properties of the individual adherent cells. Specialized equipment is required for producing the magnetic fields used in this technique.
Kasza, K. E. +7 more
openaire +4 more sources
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Investigations of dynamic light scattering properties in fluorescent solution: A comprehensive study using plasmonic enhanced Flow-Cytometry [PDF]
arXiv, 2017 In this article we present a new diagnostic approach utilizing flow-cytometry to study compounds of nanoparticle samples in solution by analysis of their scattering patterns retrieved from the cytometric measurements. As a specific enhancement of this technique we study as well the scattering pattern of nanoparticles in a fluorescent solution (529 nm).
arxiv
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Application of flow cytometry and cell sorting to megakaryocytopoiesis [PDF]
, 1979 Alexander Nakeff +3 more
openalex +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
High resolution dual laser flow cytometry. [PDF]
, 1978 P. N. Dean, Daniel Pinkel
openalex +1 more source