Results 31 to 40 of about 1,338,388 (333)

ImmPort, toward repurposing of open access immunological assay data for translational and clinical research [PDF]

, 2018
Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging ...
Bhattacharya, Sanchita, Butte, Atul, Chen, Jieming, Dunn, Patrick, Hu, Zicheng, Schaefer, Henry, Shankar, Ravi, Shen-Orr, Shai, Smith, Barry, Thomas, Cristel, Thomson, Elizabeth, Wiser, Jeffrey, Zalocusky, Kelly   +12 more
core   +2 more sources

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. [PDF]

, 2016
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Abdel-Mohsen, Mohamed, Burwitz, Benjamin J, Chew, Glen M, Clayton, Kiera L, Deeks, Steven G, Fujita, Tsuyoshi, Hammond, Katherine B, Hansen, Scott G, Hecht, Frederick M, Ishii, Naoto, Korman, Alan J, Liegler, Teri, Maurer, Mark, Mitchell, Brooks I, Ndhlovu, Lishomwa C, Ostrowski, Mario, Reed, Jason S, Sacha, Jonah B, Shikuma, Cecilia M, Webb, Gabriela M, Wu, Helen L   +20 more
core   +3 more sources

Current trends in flow cytometry automated data analysis software

Cytometry Part A, 2021
Automated flow cytometry (FC) data analysis tools for cell population identification and characterization are increasingly being used in academic, biotechnology, pharmaceutical, and clinical laboratories. The development of these computational methods is
Melissa Cheung, Jonathan J. Campbell, L. Whitby, R. Thomas, J. Braybrook, J. Petzing   +5 more
semanticscholar   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

The role of the dehydration stage in the post-hypertonic hemolysis of mammalian erythrocytes

Біологія тварин, 2021
The aim of this study was to assess the level of damage to mammalian erythrocytes under post-hypertonic shock depending on the concentration of NaCl in the dehydration medium and to determine the effect of hypertonic NaCl solutions on the condition of ...
O. E. Nipot, O. O. Shapkina, P. M. Zubov, N. V. Orlova, N. M. Shpakova   +4 more
doaj   +1 more source

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy. [PDF]

, 2019
The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to gain mechanistic insight and identify predictive signatures for personalization.
Amir, El-Ad D, Babdor, Joel, Bendall, Sean C, Gherardini, Pier Federico, Hartmann, Felix J, Jones, Kyle, Krutzik, Peter, Maecker, Holden T, Marquez, Diana M, Meyer, Everett, O'Donnell, Erika, Sahaf, Bita, Sigal, Natalia, Spitzer, Matthew H   +13 more
core   +3 more sources

PeacoQC: Peak‐based selection of high quality cytometry data

Cytometry Part A, 2021
In cytometry analysis, a large number of markers is measured for thousands or millions of cells, resulting in high‐dimensional datasets. During the measurement of these samples, erroneous events can occur such as clogs, speed changes, slow uptake of the ...
A. Emmaneel, K. Quintelier, D. Sichien, Paulina Rybakowska, C. Marañón, M. Alarcón-Riquelme, G. Van Isterdael, S. van Gassen, Y. Saeys   +8 more
semanticscholar   +1 more source

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

Circulation Research, 2018
Rationale: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of pro- and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional diversity of aortic leukocytes is poorly understood. Objective: We
H. Winkels, E. Ehinger, Melanie Vassallo, Konrad Buscher, Huy Q. Dinh, K. Kobiyama, A. Hamers, C. Cochain, Ehsan Vafadarnejad, A. Saliba, A. Zernecke, A. Pramod, Amlan Ghosh, N. Anto Michel, N. Hoppe, I. Hilgendorf, A. Zirlik, C. Hedrick, K. Ley, D. Wolf   +19 more
semanticscholar   +1 more source

Approaches to overcome flow cytometry limitations in the analysis of cells from veterinary relevant species [PDF]

, 2020
BACKGROUND: Flow cytometry is a powerful tool for the multiparameter analysis of leukocyte subsets on the single cell level. Recent advances have greatly increased the number of fluorochrome-labeled antibodies in flow cytometry.
Debes, Gudrun F., Hunka, Julia, Riley, John T   +2 more
core   +1 more source

Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy

eLife, 2021
For an emerging disease like COVID-19, systems immunology tools may quickly identify and quantitatively characterize cells associated with disease progression or clinical response. With repeated sampling, immune monitoring creates a real-time portrait of
Sierra M Barone, Alberta GA Paul, Lyndsey M Muehling, Joanne A Lannigan, William W Kwok, Ronald B Turner, Judith A Woodfolk, Jonathan M Irish   +7 more
doaj   +1 more source