Results 31 to 40 of about 1,097,210 (332)

Polymeric Micelles Formulation of Combretastatin Derivatives with Enhanced Solubility, Cytostatic Activity and Selectivity against Cancer Cells

Pharmaceutics, 2023
Combretastatin derivatives is a promising class of antitumor agents, tubulin assembly inhibitors. However, due to poor solubility and insufficient selectivity to tumor cells, we believe, their therapeutic potential has not been fully realized yet.
Igor D. Zlotnikov, Alexander A. Ezhov, Artem S. Ferberg, Sergey S. Krylov, Marina N. Semenova, Victor V. Semenov, Elena V. Kudryashova   +6 more
doaj   +1 more source

Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells [PDF]

, 2016
Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for relapse, and additional approaches to deplete CML LSC are needed to enhance the ...
Agarwal, Puneet, Bhatia, Ravi, Campbell, Victoria L., Chu, Su, Gaal, Karl, Holyoake, Tessa L., Hopcroft, Lisa, Jørgensen, Heather G., Lin, Allen, Zhang, Bin   +9 more
core   +1 more source

Long-term culture-initiating cells (LTC-IC) produced from CD34+ cord blood cells with limiting dilution method

Turkish Journal of Hematology, 2010
Objective: Even though much progress has been made in defining primitive hematologic cell phenotypes by using flow cytometry and clonogenic methods, the direct method for study of marrow repopulating cells still remains to be elusive.
Gülderen Yanıkkaya Demirel, Tülin Budak-Alpdoğan, Sema Aktaş, Mahmut Bayık   +3 more
doaj   +3 more sources

Ensemble-Based Refinement of Landmark Annotations for DNA Ploidy Analysis in Digital Pathology

Applied Sciences
Reliable evaluation of image segmentation algorithms in digital pathology depends on high-quality annotation datasets. Landmark-type annotations, essential for cell-counting analyses, are often limited in quality or quantity for segmentation benchmarking,
Viktor Zoltán Jónás, Dániel Küttel, Béla Molnár, Miklós Kozlovszky   +3 more
doaj   +1 more source

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. [PDF]

, 2016
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Abdel-Mohsen, Mohamed, Burwitz, Benjamin J, Chew, Glen M, Clayton, Kiera L, Deeks, Steven G, Fujita, Tsuyoshi, Hammond, Katherine B, Hansen, Scott G, Hecht, Frederick M, Ishii, Naoto, Korman, Alan J, Liegler, Teri, Maurer, Mark, Mitchell, Brooks I, Ndhlovu, Lishomwa C, Ostrowski, Mario, Reed, Jason S, Sacha, Jonah B, Shikuma, Cecilia M, Webb, Gabriela M, Wu, Helen L   +20 more
core   +3 more sources

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

Absolute bacterial cell enumeration using flow cytometry

, 2017
Aim: To evaluate a flow cytometry protocol that uses reference beads for the enumeration of live and dead bacteria present in a mixture. Methods and Results: Mixtures of live and dead Escherichia coli with live:dead concentration ratios varying from 0 to
McGoverin, Cushla, Ou, Fang, Swift, Simon, Vanholsbeeck, Frederique   +3 more
core   +1 more source

The dynamics of genome replication using deep sequencing [PDF]

, 2013
Peer reviewedPublisher ...
Agier, Alessandro P.S. de Moura, Alvino, Besnard, Bouton, Breier, Carolin A. Müller, Celniker, Chang, Conrad A. Nieduszynski, Cosgrove, Crampton, de Moura, De Piccoli, Di Rienzi, Eaton, Feng, Friedman, Gilbert, Hoggard, Huang, Katsuhiko Shirahige, Kearsey, Knott, Knott, Koren, Koren, Liachko, Lian, Makiko Komata, Martin J. Blythe, McGuffee, Mechali, Mechali, Mesner, Michelle Hawkins, Muller, Nakato, Natsume, Newman, Ng, Nieduszynski, Palzkill, Raghuraman, Ray Wilson, Renata Retkute, Retkute, Retkute, Rhind, Rudolph, Ryuichiro Nakato, Sekedat, Sharma, Shirahige, Siow, Sunir Malla, Theis, Theis, Theis, Vujcic, Xu, Xu, Yabuki, Yamashita, Yoshikawa   +64 more
core   +3 more sources

Methods for assessment of the tumour microenvironment and immune interactions in non-small cell lung cancer. A narrative review

Frontiers in Oncology, 2023
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide. Immunotherapy with immune checkpoint inhibitors (ICI) has significantly improved outcomes in some patients, however 80-85% of patients receiving immunotherapy ...
Kanishka Rangamuwa, Kanishka Rangamuwa, Christian Aloe, Michael Christie, Marie-Liesse Asselin-Labat, Daniel Batey, Lou Irving, Thomas John, Steven Bozinovski, Tracy L. Leong, Tracy L. Leong, Daniel Steinfort, Daniel Steinfort   +12 more
doaj   +1 more source

Prognostic significance of DNA cytometry in cutaneous malignant lymphomas. [PDF]

, 1991
The current classification of cutaneous malignant lymphomas (ML) into low-grade and high-grade lymphomas was found to be of limited reproducibility and permitted only a rough prediction about outcome.
Abmayr, Wolfgang, Braun-Falco, Otto, Burg, Günter, Dummer, Reinhard, Eckert, Fritjof, Kaudewitz, Peter, Stolz, Wilhelm, Vogt, Thomas   +7 more
core   +1 more source