Results 131 to 140 of about 1,426,971 (334)
General introduction to cytoplasm
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1969 A mere glance at figures 1 and 2 is enough to demonstrate, in a schematic way, how different our present understanding of cell structure is from that of E. B. Wilson, some 40 years ago: while the essential constituents of the cell nucleus were already known, the cytoplasm had an alveolar (or fibrillar) structure, where no cell organelles (besides the ...
openaire +4 more sources
Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity
FEBS Open Bio, EarlyView.This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang +6 more
wiley +1 more source
Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension. [PDF]
, 2017 Objective:Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Collak, Filiz Kisaayak +4 more
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The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
LOCALIZATION OF RIBONUCLEIC ACID IN THE CYTOPLASM OF LIVER CELLS [PDF]
, 1946 Eugene L. Opie, George I. Lavin
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FEBS Open Bio, EarlyView.TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo +11 more
wiley +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
Pre-ribosomal particles from nucleoli to cytoplasm
NucleusThe analysis of nucleocytoplasmic transport of proteins and messenger RNA has been the focus of advanced microscopic approaches. Recently, it has been possible to identify and visualize individual pre-ribosomal particles on their way through the nuclear ...
Ulrich Kubitscheck, Jan Peter Siebrasse
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The site of ribonucleic acid synthesis in the isolated nucleus [PDF]
, 1961 There is still controversy concerning the primary site of RNA synthesis in the cell.(1) When tissues are radioautographed after administration of radioactive inorganic phosphorus or radioactive RNA(2) precursors such as tritiated uridine or cytidine, it ...
Bonner, James, Rho, Joon H.
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