Spatial control of irreversible protein aggregation [PDF]
, 2018 Liquid cellular compartments spatially segregate from the cytoplasm and can regulate aberrant protein aggregation, a process linked to several medical conditions, including Alzheimer's and Parkinson's diseases.
Mahadevan, L. +2 more
core +2 more sources
eLife, 2016 Biological macromolecules function in highly crowded cellular environments. The structure and dynamics of proteins and nucleic acids are well characterized in vitro, but in vivo crowding effects remain unclear.
I. Yu +6 more
semanticscholar +1 more source
Additivities for Soluble Recombinant Protein Expression in Cytoplasm of Escherichia coli
FermentationRecombinant protein expression in Escherichia coli is a fundamental technique in molecular biology and biotechnology. This review provides a comprehensive overview of various additivities to enhance the expression levels of soluble recombinant proteins ...
Denis L. Atroshenko +3 more
doaj +1 more source
Cell nuclei have lower refractive index and mass density than cytoplasm
Journal of Biophotonics, 2016 Common perception regards the nucleus as a densely packed object with higher refractive index (RI) and mass density than the surrounding cytoplasm. Here, the volume of isolated nuclei is systematically varied by electrostatic and osmotic conditions as ...
M. Schürmann +4 more
semanticscholar +1 more source
An Unsupervised Approach for Overlapping Cervical Cell Cytoplasm Segmentation
, 2017 The poor contrast and the overlapping of cervical cell cytoplasm are the major issues in the accurate segmentation of cervical cell cytoplasm. This paper presents an automated unsupervised cytoplasm segmentation approach which can effectively find the ...
Chatterjee, Swarnadip +4 more
core +1 more source
Magnetic wire as stress controlled micro-rheometer for cytoplasm viscosity measurements [PDF]
, 2018 We review here different methods to measure the bulk viscosity of complex fluids using micron-sized magnetic wires. The wires are characterized by length of a few microns and diameter of a few hundreds of nanometers.
Berret, Jean-Francois
core +3 more sources
Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel [PDF]
, 2013 Confocal Raman microscopy is a noninvasive, label-free imaging technique used to study apoptosis of live MCF-7 cells. The images are based on Raman spectra of cells components, and their apoptosis is monitored through diffusion of cytochrome c in ...
Attila-Gergely Vegh +7 more
core +1 more source
Expression of the gene for main intrinsic polypeptide (MIP): separate spatial distributions of MIP and beta-crystallin gene transcripts in rat lens development [PDF]
, 1988 The main intrinsic polypeptide (MIP) is the major protein present in the lens fiber cell membrane and is the product of a gene which, as far as is known, is expressed only in the lens.
Chung, Johnson +3 more
core +1 more source
Universal glass-forming behavior of in vitro and living cytoplasm
Scientific Reports, 2017 Physiological processes in cells are performed efficiently without getting jammed although cytoplasm is highly crowded with various macromolecules. Elucidating the physical machinery is challenging because the interior of a cell is so complex and driven ...
K. Nishizawa +5 more
semanticscholar +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source