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Multiple modes of cytoplasmic dynein regulation
Nature Cell Biology, 2012In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity.
Richard B, Vallee +2 more
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1999
Abstract Cytoplasmic dynein is a large, two-headed ATPase which produces force along microtubules in the retrograde direction (toward the microtubufe minus end). It is involved in a wide range of functions, including retrograde axonal transport and mitosis, and it associates with numerous subcellular structures, including kinetochores ...
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Abstract Cytoplasmic dynein is a large, two-headed ATPase which produces force along microtubules in the retrograde direction (toward the microtubufe minus end). It is involved in a wide range of functions, including retrograde axonal transport and mitosis, and it associates with numerous subcellular structures, including kinetochores ...
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Substructure of sea urchin egg cytoplasmic dynein
Journal of Molecular Biology, 1987The substructure of the cytoplasmic dynein molecule was studied using the quick-freeze, deep-etch technique. Cytoplasmic dynein purified as a 12 S form from the eggs of the sea urchin Hemicentrotus pulcherrimus was composed of a single high molecular weight polypeptide.
S, Hisanaga, N, Hirokawa
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Axonal transport: beyond kinesin and cytoplasmic dynein
Current Opinion in Neurobiology, 1991In vitro and in vivo studies of specific neuronal fast and slow transport components are presently reshaping our understanding of how the processes of vesicular and cytoskeletal transport are regulated in axons and dendrites. Evidence suggests that vesicles possess an inherent directionality, possibly the result of their motor receptor proteins ...
M P, Sheetz, C H, Martenson
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An improved purification method for cytoplasmic dynein
Journal of Cellular Biochemistry, 1984AbstractAn improved method has been devised for the purification of cytoplasmic dynein from sea urchin eggs (Strongylocentrotus droebachiensis and S purpuratus). This protocol introduces three changes over a previously published procedure (Hisanaga and Sakai: J Biochem 93:87, 1983)—the substitution of diethylaminoethyl (DEAE)‐cellulose for ...
M M, Pratt, S, Hisanaga, D A, Begg
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Cytoplasmic dynein: advances in microtubule-based motility
Trends in Cell Biology, 1991It is four years since the discovery that a cytoplasmic form of dynein was able to produce force along microtubules in the opposite direction to kinesin. Recent evidence has supported a role for this cytoplasmic dynein in retrograde organelle transport, as well as other forms of intracellular motility.
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Single-molecule imaging of cytoplasmic dynein in vivo
2015While early fluorescence microscopy experiments employing fluorescent probes afforded snapshots of the cell, the power of live-cell microscopy is required to understand complex dynamics in biological processes. The first successful cloning of green fluorescent protein in the 1990s paved the way for development of approaches that we now utilize for ...
Ananthanarayanan, Vaishnavi +1 more
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Structure, function and regulation of cytoplasmic dynein
Current Opinion in Cell Biology, 1994Molecular cloning studies have provided valuable structural information about the different subunits of cytoplasmic dynein and their relationships to their axonemal dynein counterparts. Recent unexpected findings regarding the role of this enzyme in mitosis have emerged from mutational analyses and microinjection experiments, while studies of organelle
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Cytoplasmic preassembly and trafficking of axonemal dyneins
, 2018Paurav B. Desai +3 more
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