Results 161 to 170 of about 420,555 (284)

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Wolbachia Infections in Aedes aegypti Differ Markedly in Their Response to Cyclical Heat Stress.

PLoS Pathogens, 2017
Aedes aegypti mosquitoes infected with Wolbachia bacteria are currently being released for arbovirus suppression around the world. Their potential to invade populations and persist will depend on interactions with environmental conditions, particularly ...
Perran A Ross, Itsanun Wiwatanaratanabutr, Jason K Axford, Vanessa L White, Nancy M Endersby-Harshman, Ary A Hoffmann   +5 more
doaj   +1 more source

Wolbachia diversity and cytoplasmic incompatibility patterns in Culex pipiens populations in Turkey

Parasites & Vectors, 2018
Background Wolbachia are maternally transmitted bacteria that can manipulate their hosts’ reproduction causing cytoplasmic incompatibility (CI). CI is a sperm-egg incompatibility resulting in embryonic death. Due to this sterilising effect on mosquitoes,
Mine Altinli, Filiz Gunay, Bulent Alten, Mylene Weill, Mathieu Sicard   +4 more
doaj   +1 more source

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng, Ying Fang, Hongwei Yu, Yicheng Wang, Yunze Xu, Chunxiao Shi, Haike Xia, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu   +10 more
wiley   +1 more source

Comparative genomics suggests an independent origin of cytoplasmic incompatibility in Cardinium hertigii.

PLoS Genetics, 2012
Terrestrial arthropods are commonly infected with maternally inherited bacterial symbionts that cause cytoplasmic incompatibility (CI). In CI, the outcome of crosses between symbiont-infected males and uninfected females is reproductive failure ...
Thomas Penz, Stephan Schmitz-Esser, Suzanne E Kelly, Bodil N Cass, Anneliese Müller, Tanja Woyke, Stephanie A Malfatti, Martha S Hunter, Matthias Horn   +8 more
doaj   +1 more source

Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility

Current Biology, 2022
B. Horard, Kévin Terretaz, A. Gosselin-Grenet, Hélène Sobry, M. Sicard, Frédéric Landmann, B. Loppin   +6 more
semanticscholar   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

Comparative genomics of Rickettsiella bacteria reveal variable metabolic pathways potentially involved in symbiotic interactions with arthropods

Peer Community Journal
Members of the Rickettsiella genus (order: Legionellales) are emerging as widespread bacteria associated with insects, arachnids, and crustaceans.
Floriano, Anna M., El-Filali, Adil, Amoros, Julien, Buysse, Marie, Jourdan-Pineau, Hélène, Sprong, Hein, Kohl, Robert, Dirks, Ron P., Schaap, Peter, Koehorst, Jasper, Nijsse, Bart, Bouchon, Didier, Daubin, Vincent, Vavre, Fabrice, Duron, Olivier   +14 more
doaj   +1 more source