Results 261 to 270 of about 39,037 (343)
Cell Proliferation, EarlyView.RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu +12 more
wiley +1 more source
Cell Proliferation, EarlyView.EC‐EXOs could regulate the differentiation of BMSCs through the key protein THBS3, which inhibits their differentiation to lipogenic cells and promotes their differentiation to osteoblasts. THBS3 could down‐regulate the expression of its downstream target CD47 and delay the process of bone loss in aged mice and OVX mice, which may provide a novel ...
Jiaojiao Wang +8 more
wiley +1 more source
YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice
Cell Proliferation, EarlyView.Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen +8 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Following emerging evidence of autoimmune‐associated seizures in medication‐refractory epilepsy, we began offering a trial of immunotherapy to selected patients. Here, we review this approach's treatment response, predictive clinical features, and utility.
Elisabeth Doran +4 more
wiley +1 more source
Discovery of MicroRNAs Associated with the S Type Cytoplasmic Male Sterility in Maize
, 2013 Jianghua Yu +5 more
openalex +1 more source
The FEBS Journal, EarlyView.Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés +19 more
wiley +1 more source
Melanoma cells suppress mast cell function via a melanin‐dependent mechanism
The FEBS Journal, EarlyView.Mast cells are frequently found in melanoma tumors, and here we investigated whether melanoma cells can influence mast cell function. Our study reveals that melanin, secreted from melanoma cells, is taken up by mast cells and can reach the mast cell nucleus.
Fábio Rabelo Melo +4 more
wiley +1 more source