Results 71 to 80 of about 14,889 (286)

The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Cancer emergence is associated with a series of cellular transformations that include acquired drug resistance followed by tumor metastasis. Matrix metalloproteinases (MMPs) and Hsp90 chaperone are implicated in tumor progression, however, they are not studied in the context of drug resistance. Aims In the present study, we aimed at
Pankaj Kumar, Satish Siripini, Amere Subbarao Sreedhar   +2 more
wiley   +1 more source

Efficacy of the Sterile Insect Technique in the presence of inaccessible areas: A study using two-patch models [PDF]

Mathematical Biosciences, pp.109290
The Sterile Insect Technique (SIT) is one of the sustainable strategies for the control of disease vectors, which consists of releasing sterilized males that will mate with the wild females, resulting in a reduction and, eventually a local elimination, of the wild population.
arxiv   +1 more source

Implementation of Control Strategies for Sterile Insect Techniques [PDF]

, 2018
In this paper, we propose a sex-structured entomological model that serves as a basis for design of control strategies relying on releases of sterile male mosquitoes (Aedes spp) and aiming at elimination of the wild vector population in some target locality.
arxiv   +1 more source

Clinicopathological correlation of p40/TTF1 co-expression in NSCLC and review of related literature [PDF]

arXiv, 2022
TTF1 and {\Delta}Np63/p40 have been used to differentiate ADC and SQC in hypofractionated NSCLC because of their sensitivity and specificity. There are few cases where TTF1 and {\Delta}Np63/p40 are expressed together in the same tumour cells, and little is known about the clinicopathological features, treatment and prognosis of such cases.
arxiv  

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Mitochondrial localization of ORF346 causes pollen abortion in alloplasmic male sterility

Crop Journal, 2021
The Nsa cytoplasmic male sterility (CMS) system confers stable male sterility and offers great potential for production of hybrid seeds in oilseed rape. However, genes responsible for male sterility in Nsa CMS have not been identified.
Shifei Sang, Hongtao Cheng, Mengyu Hao, Bingli Ding, Desheng Mei, Hui Wang, Wenxiang Wang, Jia Liu, Li Fu, Kede Liu, Qiong Hu   +10 more
doaj  

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis

Advanced Science, EarlyView.
This study verifies that circRNA‐mTOR exhibits high expression levels in HCC and has a strong correlation with patient prognosis. Mechanistically, circRNA‐mTOR achieves this effect by facilitating the nuclear translocation of RNA‐binding protein (RBP) PSIP1 through specific binding.
Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren, Yuxuan Li, Gaoyuan Yang, Zhaozhong Zhong, Hao Liang, Zhiyong Xiong, Zhiwei He, Nan Lin, Meihai Deng, Zhicheng Yao   +12 more
wiley   +1 more source

Pyrus ussuriensis Maxim 70% ethanol eluted fraction ameliorates inflammation and oxidative stress in LPS‐induced inflammation in vitro and in vivo

Food Science &Nutrition, Volume 11, Issue 1, Page 458-469, January 2023., 2023
In this work, we demonstrated that PUM70 specifically suppressed LPS‐mediated inflammatory responses. Notably, PUM70 treatment inhibited LPS‐induced lung damage, pro‐inflammatory cytokine production, and reduced macrophage infiltration in the lungs. Mechanistically, PUM70 suppressed LPS‐induced inflammation and oxidative stress via the Nrf2/HO‐1 and ...
Fei Peng, Xin Ren, Bin Du, Yuedong Yang
wiley   +1 more source

Progress on studies for seedless breeding of citrus in Japan

Advances in Horticultural Science, 2014
Seedlessness is a desirable characteristic for both fresh and processed citrus markets and one of the most important breeding objectives. In this paper, progress on studies for seedless breeding of citrus in Japan is reviewed.
M. Yamamoto
doaj   +1 more source