Results 31 to 40 of about 1,471,694 (149)

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Fertility counseling and preservation considerations in patients with gynecologic and non‐gynecologic BRCA and Lynch‐associated malignancies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Lynch syndrome and BRCA‐mutation associated malignancies are fortunately rare. Affected patients have an increased risk of cancer diagnosis at a young age, often significantly overlapping with their reproductive years. In helping these patients, oncologists must navigate the following areas of care: cancer prevention, impact of cancer ...
Anna Weimer, Nadeem Abu‐Rustum, David Mutch, Mauricio Cuello, Angélica Fletcher, Hextan Y. S. Ngan, Nozomu Yanaihara, Rene Pareja, Christina Fotopoulou, Kenneth Ruzindana, Ka Yu Tse, Yana Zou, Neerja Bhatla, Ting‐Chang Chang, Munanchiso Ndukwe Iheme Jr, Jalid Sehouli, Nicole Conchin, Eva Chalas, Sarikapan Wilailak, Barbara Schmalfeldt, Alexander B. Olawaiye   +20 more
wiley   +1 more source

Recurrent Ovarian Cancer with the Involvement of Urinary Organs: is There Place for Secondary Cytoreductive Surgery?

Galician Medical Journal, 2017
The objective of the research was to estimate early and long-term results of secondary cytoreductive surgery performed for recurrent ovarian cancer with involvement of urinary organs. Materials and methods. The study included 62 patients with recurrent
Kateryna Kharchenko
doaj   +1 more source

Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer

Holistic Integrative Oncology
Objective To investigate the clinical efficacy of cytoreductive surgery in oligometastatic hormone-sensitive prostate cancer (omHSPC). Methods The basic characteristics, treatment strategies and long-term follow-up of 181 patients with omHSPC were ...
Feng Qi, Yihang Xu, Zicheng Xu, Qing Zou
doaj   +1 more source

Cytoreductive Surgery and Hyperthermic İntraperitoneal Chemoterapy for Advance Gastric Cancer Associated Peritoneal Carcinomatosis Single Centre Unit for 10 Consecutive Patients

, 2019
Aim:Hyperthermic intraperitoneal chemotherapy with cytoreductive surgery has a positive effect on survival in advanced abdominal cancers. We aimed to present our experience with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in ...
Ömer Faruk Özkan, kalın, murat, Sema Yüksekdağ, Özgül Düzgün, KÖKSAL, NEŞET, DÜZGÜN, ÖZGÜL, Şenol Çomoğlu, ÖZKAN, ÖMER FARUK, Çomoğlu, Şenol, Murat Kalın, Neşet Köksal, yüksekdağ, sema, Yanık, Semra, Semra Yanık   +13 more
core   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Advanced low grade serous ovarian cancer: A retrospective analysis of surgical and chemotherapeutic management in two high volume oncological centers

Frontiers in Oncology, 2022
Simple summaryLow-grade serous ovarian cancer (LGSOC) represents an uncommon histotype of serous ovarian cancer (accounting for approximately 5% of all ovarian cancer) with a distinct behavior compared to its high-grade serous counterpart, characterized ...
Paolo Di Lorenzo, Paolo Di Lorenzo, Vincenza Conteduca, Vincenza Conteduca, Emanuela Scarpi, Marco Adorni, Francesco Multinu, Annalisa Garbi, Ilaria Betella, Tommaso Grassi, Tommaso Bianchi, Giampaolo Di Martino, Andrea Amadori, Paolo Maniglio, Isabella Strada, Silvestro Carinelli, Marta Jaconi, Giovanni Aletti, Giovanni Aletti, Vanna Zanagnolo, Angelo Maggioni, Luca Savelli, Ugo De Giorgi, Fabio Landoni, Nicoletta Colombo, Nicoletta Colombo, Robert Fruscio, Robert Fruscio   +27 more
doaj   +1 more source

Perioperative Risks of Concurrent Pancreatic and Hepatic Resections for Neuroendocrine Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Pancreatic neuroendocrine tumors (pNETs) account for 1%–2% of pancreatic tumors, with an increasing incidence. The safety of concurrent pancreas‐liver resections remains uncertain. This study evaluated the national outcomes of concurrent pancreatectomy and liver‐directed surgery for pNETs. Methods ACS‐NSQIP (2019–2023)
Amir Ebadinejad, Ashrita Raghuram, Sophia Xiao, Ethan Angle, Hassan Aziz   +4 more
wiley   +1 more source

Cytoreductive Surgery in Ovarian Cancer: Why, When, and How?

, 1996
Retrospective evidence supports the value of optimal cytoreductive surgery in the initial therapy of patients with advanced ovarian cancer. Specialized procedures, including radical pelvic surgery, bowel resection, and diaphragm resections, are ...
William S. Roberts
core   +1 more source

Morbidity and Mortality of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients Aged 70 Years and Older: A Two‐Center 10‐Year Experience

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is established for peritoneal surface malignancies, but its use in older patients is debated. We assessed CRS‐HIPEC morbidity and mortality in patients aged ≥ 70 years using a cohort of younger patients as a comparator.
Ali Ediz Kıvanç, Mehmet Oduncu, Pırıltı Özcan, Özgül Düzgün, Neşet Köksal   +4 more
wiley   +1 more source