Results 81 to 90 of about 2,605,313 (261)

Intraperitoneal chemotherapy for gastric cancer with peritoneal carcinomatosis: is HIPEC the only answer? [PDF]

, 2014
Gastric cancer with peritoneal carcinomatosis is notorious for its dismal prognosis. While the pathophysiology of peritoneal dissemination is still controversial, the rapid downhill course is universal.
Kwong, DLW, Lam, KO, Law, BTT, Law, SYK
core   +1 more source

Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients

International Journal of Cancer, Volume 158, Issue 7, Page 1821-1835, 1 April 2026.
What's new? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman, Nahal Masrour, Naina Patel, Anna M. Piskorz, Robert Brown, James D. Brenton, Iain A. McNeish, James M. Flanagan   +7 more
wiley   +1 more source

Systematic Pelvic and Paraaortic Lymph Node Dissection in Advanced Ovarian Cancer—Technical Aspects and Current Evidence-Based Data for Clinical Decision-Making

Surgical Techniques Development
Cytoreductive surgery in the context of a multidisciplinary approach, including adjuvant and neoadjuvant therapy (when indicated), aims ideally to obtain complete resection and represents the cornerstone for long-term survival in patients with advanced ...
Traian Dumitrascu
doaj   +1 more source

Colorectal cancer with synchronous distant metastases: rationale for cytoreductive surgery and its perspectives – a surgeons view

Тазовая хирургия и онкология, 2015
A rationale for cytoreductive surgery in colorectal cancer patients with multiple liver metastases is discussed in the article. Not only does it improve their quality of life and prevent life-threatening complications, but also facilitates further ...
V. A. Aliyev, Yu. A. Barsukov, A. V. Nikolayev, R. I. Tamrazov, Z. Z. Mamedli, A. O. Atroshchenko, D. V. Kuzmichev   +6 more
doaj   +1 more source

Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial [PDF]

, 2015
Background: The peritoneum is the second most common site of recurrence in colorectal cancer. Early detection of peritoneal carcinomatosis (PC) by imaging is difficult.
Aalbers, A.G.J. (Arend), Bemelman, W.A. (Willem), Boerma, D. (Djamila), Bremers, A.J.A. (Andreas), Burger, J.W.A. (Jacobus), Buskens, C.J. (Christianne), Dijkgraaf, M.G.W. (Marcel), Evers, P. (Pauline), Grevenstein, H.M.U. (Helma) van, Hemmer, P.H.J. (Patrick H.J.), Hingh, I.H.J.T. (Ignace) de, Klaver, C.E.L. (Charlotte), Lammers, L.A. (Laureen), Leeuwen, B.L. (B.) van, Meijerink, W.J.H.J. (Jeroen), Musters, G.D. (Gijsbert), Nienhuijs, S.W. (Simon), Pon, J. (Jolien), Punt, C.J.A. (Cornelis), Radema, S.A. (Sandra A.), Ramshorst, B. (Bert) van, Snaebjornsson, P., Tanis, P.J. (Pieter), te Velde, E.A. (Elisabeth A.), Tuynman, J.B., van der Bilt, J.D.W. (Jarmila D.W.), van Ginkel, R.J. (Robert J.), Verwaal, V.J. (Vic J.), Wiezer, M.J. (Marinus), Wilt, J.H.W. (Johannes) de   +29 more
core   +4 more sources

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6)

BMC Cancer, 2019
Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in the Netherlands.
K. Rovers, C. Bakkers, G. Simkens, J. Burger, S. Nienhuijs, G. Creemers, A. M. Thijs, A. Brandt-Kerkhof, E. Madsen, N. Ayez, N. L. de Boer, E. van Meerten, J. Tuynman, M. Kusters, N. Sluiter, H. Verheul, H. J. van der Vliet, M. Wiezer, D. Boerma, E. Wassenaar, M. Los, C. B. Hunting, A. Aalbers, N. Kok, K. Kuhlmann, H. Boot, M. Chalabi, S. Kruijff, L. Been, R. V. van Ginkel, D. D. de Groot, R. Fehrmann, J. D. de Wilt, A. Bremers, P. D. de Reuver, S. Radema, K. Herbschleb, W. V. van Grevenstein, A. Witkamp, M. Koopman, N. Haj Mohammad, E. V. van Duyn, W. Mastboom, L. Mekenkamp, J. Nederend, M. Lahaye, P. Snaebjornsson, C. Verhoef, H. V. van Laarhoven, A. Zwinderman, J. Bouma, O. Kranenburg, I. van ’t Erve, R. Fijneman, M. Dijkgraaf, P. Hemmer, C. Punt, P. Tanis, I. D. de Hingh   +58 more
semanticscholar   +1 more source

A Cost Consequence Analysis of Seven Diagnostic Strategies for Ovarian Cancer: A Model‐Based Economic Evaluation

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 4, Page 680-689, March 2026.
ABSTRACT Objective To assess the costs and consequences of seven diagnostic strategies for ovarian cancer in pre‐ and post‐menopausal women with symptoms in secondary care. Design Economic evaluation alongside a prospective single‐arm diagnostic accuracy study.
Samuel J. Perry, Donal Griffin, Eleanor V. Williams, Tracy E. Roberts, Fong Lien Kwong, Sarah Williams, Jon Deeks, Katie Scandrett, Ridhi Agarwal, Sudha S. Sundar, Mark Monahan   +10 more
wiley   +1 more source

Oncologic outcomes after splenectomy during initial cytoreductive surgery in advanced epithelial ovarian cancer: a nationwide population‐based cohort study

Acta Obstetricia et Gynecologica Scandinavica, 2022
Introduction Epithelial ovarian cancer (EOC) patients undergoing splenectomy during cytoreductive surgery represent a small subgroup of patients. Splenic metastases or technical reasons due to extensive upper abdominal disease may require a splenectomy ...
Sherin A. Said, Maaike A. van derAa, Guus Veldmate, Joanne A. deHullu, Anne M. vanAltena   +4 more
doaj   +1 more source

Cytoreductive Surgery for Advanced Ovarian Cancer [PDF]

Women's Health, 2014
The amount of the largest diameter of visible residual tumor after cytoreductive surgery remains one of the strongest prognostic factors In advanced ovarian cancer. The Implementation of a more aggressive surgical approach to Increase the proportion of patients without visible residual tumor Is, therefore, a rational concept.
Martin, Pölcher, Oliver, Zivanovic, Dennis S, Chi   +2 more
openaire   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, Volume 16, Issue 2, Page 432-446, February 2026.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source