Results 151 to 160 of about 52,861 (267)

Telomere‐to‐telomere reference genome reveals subgenome divergence and large structural variants in Capsella bursa‐pastoris (Brassicaceae)

open access: yesBiological Diversity, EarlyView.
This study presents a subgenome‐resolved telomere‐to‐telomere reference genome of Capsella bursa‐pastoris, named Cbp_T2T, constructed using PacBio HiFi reads, Nanopore ultra‐long reads, and Hi‐C data. Notable divergences were observed between its subgenomes, and comparative genomics identified two large inversions within the species.
Xin Liu   +4 more
wiley   +1 more source

Characterization of large transgene integrations in Chinese hamster ovary cells using a bioengineered mammalian transposase

open access: yesBiotechnology Progress, EarlyView.
Abstract We present the first use of a bioengineered mammalian transposase system derived from Myotis lucifugus (bMLT) for integration of expression vectors into the CHO genome, focusing on GFP and trastuzumab production. Initially, CHO‐K1 cells are transfected with a GFP reporter and varying amounts of bMLT DNA or mRNA.
Nicolas Marx   +10 more
wiley   +1 more source

Cytogenetic and Morphologic Abnormalities in Human Bone Marrow Cells during Cytosine Arabinoside Therapy [PDF]

open access: bronze, 1966
William R. Bell   +4 more
openalex   +1 more source

Cucurbit[7]uril‐Styryl Dye Complexes for Fluorescent Recognition of DNA and Cell Imaging

open access: yesChemBioChem, EarlyView.
Recognition properties in solution and in cancer cells: a two dicationic cyanine dyes with different functionalities were developed and studied for their fluorescent properties, cytotoxicity and cellular imaging. The effect of encapsulation was checked using synthetic molecular container of cucurbit[7]uril.
Ekaterina Y. Chernikova   +7 more
wiley   +1 more source

Are β3‐adrenoceptor gene polymorphisms relevant for urology?

open access: yesNeurourology and Urodynamics, Volume 42, Issue 1, Page 33-39, January 2023., 2023
Abstract Aims β3‐adrenoceptors (ARs) are an important drug target for the treatment of overactive bladder syndrome (OAB) and are under investigation for other indications. The human β3‐AR gene is polymorphic; an exchange of amino acid tryptophan (Trp) for arginine (Arg) in position 64 of the receptor protein is the most frequent and best‐studied ...
Martin C. Michel
wiley   +1 more source

Synthesis and Metal‐Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2‐Diamine Groups

open access: yesChemBioChem, EarlyView.
The findings of thermal denaturation experiments indicate that duplexes containing thymine analogues with 1,2‐ethylenediamine side chains show stabilizing effects with six metal ions (e.g., Cu(II), Ni(II), Zn(II), Co(II), Cd(II)). The 1,2‐diamine side chain demonstrated to be useful as a new metal‐ion binding site. Thymidine analogue with a 1,2‐diamino
Takahiro Atsugi   +3 more
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

open access: yesChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout   +1 more
wiley   +1 more source

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