Results 131 to 140 of about 233,386 (297)
FXTAS and the Spectrum of FMR1 Premutation‐Associated Phenotypes in Latin America: A Scoping Review
Movement Disorders Clinical Practice, EarlyView.Abstract Background Fragile X–associated tremor/ataxia syndrome (FXTAS) is a late‐onset neurodegenerative disorder caused by FMR1 premutation expansions (55–200 CGG repeats). Although well described in populations of predominantly European ancestry, FXTAS remains poorly characterized in Latin America due to limited awareness, restricted access to ...
Amy Schmidmajer +6 more
wiley +1 more source
Prognostic factors for 1-week survival in dogs diagnosed with meningoencephalitis of unknown aetiology [PDF]
, 2016 Barnoon +17 more
core +1 more source
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
Med Research, EarlyView.The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source
In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease
Movement Disorders, EarlyView.Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale +11 more
wiley +1 more source
Movement Disorders, EarlyView.Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar +15 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes +9 more
wiley +1 more source
Multifunktionale DNA‐Moiré‐Supergitter: Moiré‐Strukturen aus den Bausteinen des Lebens
Physik in unserer Zeit, EarlyView.Moiré‐Strukturen sind längst ein Schlüsselbegriff in der modernen Festkörperphysik. Sie entstehen, wenn sich zwei periodische Materialgitter mit leicht unterschiedlichen Gitterkonstanten oder Orientierungen übereinanderlagern. Das so entstehende großflächige Interferenzmuster, das als Moiré‐Muster bezeichnet wird, kann die physikalischen Eigenschaften ...
Andreas Peil, Xinxin Jing, Laura Na Liu
wiley +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source