CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity [PDF]
BMC Genetics, 2020 Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Manthan Patel +3 more
doaj +2 more sources
The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression [PDF]
BMC Genomic DataCGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation.
Ishani Morbia +5 more
doaj +2 more sources
Frontiers in Genetics, 2015 DNA cytosine methylation is a widespread epigenetic mechanism in eukaryotes, and plant genomes commonly are densely methylated. Genomic methylation can be associated with functional consequences such as mutational events, genomic instability or altered ...
Conchita eAlonso +3 more
doaj +3 more sources
Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme [PDF]
Molecular Cancer, 2020 Background Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully elucidated.
Mathilde Cheray +15 more
doaj +2 more sources
PLoS ONE, 2015 While cytosine methylation has been widely studied in extant populations, relatively few studies have analyzed methylation in ancient DNA. Most existing studies of epigenetic marks in ancient DNA have inferred patterns of methylation in highly degraded ...
Rick W A Smith +2 more
doaj +2 more sources
Inheritance and variation of Cytosine methylation in three populus allotriploid populations with different heterozygosity. [PDF]
PLoS ONE, 2015 DNA methylation is an epigenetic mechanism with the potential to regulate gene expression and affect plant phenotypes. Both hybridization and genome doubling may affect the DNA methylation status of newly formed allopolyploid plants.
Yujing Suo, Chunbo Dong, Xiangyang Kang
doaj +3 more sources
Sugarcane mosaic virus mediated changes in cytosine methylation pattern and differentially transcribed fragments in resistance-contrasting sugarcane genotypes. [PDF]
PLoS ONE, 2020 Sugarcane mosaic virus (SCMV) is the causal agent of sugarcane mosaic disease (SMD) in Brazil; it is mainly controlled by using resistant cultivars. Studies on the changes in sugarcane transcriptome provided the first insights about the molecular basis ...
Marcel Fernando da Silva +6 more
doaj +2 more sources
Information Thermodynamics of Cytosine DNA Methylation. [PDF]
PLoS ONE, 2016 Cytosine DNA methylation (CDM) is a stable epigenetic modification to the genome and a widespread regulatory process in living organisms that involves multicomponent molecular machines.
Robersy Sanchez, Sally A Mackenzie
doaj +4 more sources
Challenges in Quantifying Cytosine Methylation in the HIV Provirus. [PDF]
mBio, 2019 DNA methylation is an epigenetic mechanism most commonly associated with transcriptional repression. While it is clear that DNA methylation can silence HIV proviral expression in in vitro latency models, its correlation with HIV persistence and expression in vivo is ambiguous, particularly in
LaMere SA +4 more
europepmc +6 more sources
Myxosporea (Myxozoa, Cnidaria) Lack DNA Cytosine Methylation [PDF]
Molecular Biology and Evolution, 2021 Agusto Luzuriaga-Neira +2 more
exaly +2 more sources