CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity [PDF]
BMC Genetics, 2020 Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Manthan Patel +3 more
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Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme [PDF]
Molecular Cancer, 2020 Background Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully elucidated.
Mathilde Cheray +15 more
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The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression [PDF]
BMC Genomic DataCGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation.
Ishani Morbia +5 more
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PLoS ONE, 2015 While cytosine methylation has been widely studied in extant populations, relatively few studies have analyzed methylation in ancient DNA. Most existing studies of epigenetic marks in ancient DNA have inferred patterns of methylation in highly degraded ...
Deborah Bolnick +2 more
exaly +2 more sources
Frontiers in Genetics, 2015 DNA cytosine methylation is a widespread epigenetic mechanism in eukaryotes, and plant genomes commonly are densely methylated. Genomic methylation can be associated with functional consequences such as mutational events, genomic instability or altered ...
Conchita Alonso +2 more
exaly +3 more sources
Sugarcane mosaic virus mediated changes in cytosine methylation pattern and differentially transcribed fragments in resistance-contrasting sugarcane genotypes. [PDF]
PLoS ONE, 2020 Sugarcane mosaic virus (SCMV) is the causal agent of sugarcane mosaic disease (SMD) in Brazil; it is mainly controlled by using resistant cultivars. Studies on the changes in sugarcane transcriptome provided the first insights about the molecular basis ...
Marcel Fernando da Silva +6 more
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The methylation landscape of giga-genome and the epigenetic timer of age in Chinese pine
Nature Communications, 2023 DNA methylation level declines during aging of mammals. Here, the authors report single-base resolution landscape of cytosine DNA methylation at different ages of Chinese pine and show that the global cytosine DNA methylation gradually increases as age ...
Jiang Li +7 more
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Experimental and Computational Approaches for Non-CpG Methylation Analysis
Epigenomes, 2022 Cytosine methylation adjacent to adenine, thymine, and cytosine residues but not guanine of the DNA is distinctively known as non-CpG methylation. This CA/CT/CC methylation accounts for 15% of the total cytosine methylation and varies among different ...
Deepa Ramasamy +3 more
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Inheritance and variation of Cytosine methylation in three populus allotriploid populations with different heterozygosity. [PDF]
PLoS ONE, 2015 DNA methylation is an epigenetic mechanism with the potential to regulate gene expression and affect plant phenotypes. Both hybridization and genome doubling may affect the DNA methylation status of newly formed allopolyploid plants.
Yujing Suo, Chunbo Dong, Xiangyang Kang
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Determination of the presence of 5-methylcytosine in Paramecium tetraurelia. [PDF]
PLoS ONE, 2018 5-methylcytosine DNA methylation regulates gene expression and developmental programming in a broad range of eukaryotes. However, its presence and potential roles in ciliates, complex single-celled eukaryotes with germline-somatic genome specialization ...
Aditi Singh +5 more
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