Results 21 to 30 of about 57,661 (242)
BMC Plant Biology, 2017 Background Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or during
Martin Schmidt +7 more
doaj +1 more source
High sensitivity mapping of methylated cytosines [PDF]
Nucleic Acids Research, 1994 An understanding of DNA methylation and its potential role in gene control during development, aging and cancer has been hampered by a lack of sensitive methods which can resolve exact methylation patterns from only small quantities of DNA. We have now developed a genomic sequencing technique which is capable of detecting every methylated cytosine on ...
S J, Clark +3 more
openaire +2 more sources
Cytosine Methylation: Quantitation by Automated Genomic Sequencing and GENESCANTM Analysis
BioTechniques, 1996 Bisulfite treatment and PCR amplification of genomic DNA permits the methylation analysis of any cytosine residue in a target sequence. By cloning and sequencing the PCR product, the methylation of individual molecules can be determined, whereas direct ...
Cheryl L. Paul, Susan J. Clark
doaj +1 more source
Dissecting cytosine methylation mechanics of dysmetabolism. [PDF]
Aging (Albany NY), 2019 Cencioni C, Gaetano C, Spallotta F.
europepmc +6 more sources
Global Analysis of Cytosine Methylation and Proteome Under Cold Treatment in Brassica napus
Journal of Integrative Agriculture, 2014 Cytosine methylation/demethylation plays pivotal roles in regulating gene expression at a genome-wide level. However, limited reports are available to reveal correlating changes of cytosine methylation and proteomic expression in Brassica napus so far ...
Fang WEI +5 more
doaj +1 more source
Dynamics of Methylated Cytosine Flipping by UHRF1 [PDF]
Journal of the American Chemical Society, 2017 DNA methylation patterns, which are critical for gene expression, are replicated by DNA methyltransferase 1 (DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins. This replication is initiated by the recognition of hemimethylated CpG sites and further flipping of methylated cytosines (mC) by the Set and Ring Associated ...
Bronner, Christian +15 more
openaire +5 more sources
Epigenetics & Chromatin, 2018 Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited.
Satyanarayan Rao +5 more
doaj +1 more source
Cytosine methylation of the sequence GATC in a mycoplasma [PDF]
Journal of Bacteriology, 1982 Mycoplasma virus L2 is subject to host-specific restriction and modification in Acholeplasma laidlawii strains JA1 and K2. We have examined the DNAs from both host cells and viruses propagated on these strains with respect to susceptibility to cleavage by restriction endonucleases and for DNA base modifications.
K, Dybvig +3 more
openaire +2 more sources
Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection
Biology, 2020 DNA cytosine methylation is one of the main epigenetic mechanisms in higher eukaryotes and is considered to play a key role in transcriptional gene silencing.
Miryam Pérez-Cañamás +2 more
doaj +1 more source
From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia [PDF]
Epigenetics, 2009 The role of methylation in the history of psychiatry has traversed a storied path. The original trans-methylation hypothesis was proposed at a time when chlorpromazine had been synthesized but not yet marketed as an antipsychotic (Thorazine).
Dennis R, Grayson +4 more
openaire +2 more sources