Results 21 to 30 of about 62,191 (286)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source

The DNA methylation level against the background of the genome size and t-heterochromatin content in some species of the genus Secale L [PDF]

PeerJ, 2017
Methylation of cytosine in DNA is one of the most important epigenetic modifications in eukaryotes and plays a crucial role in the regulation of gene activity and the maintenance of genomic integrity.
Anna Kalinka, Magdalena Achrem, Paulina Poter   +2 more
doaj   +2 more sources

High sensitivity mapping of methylated cytosines [PDF]

Nucleic Acids Research, 1994
An understanding of DNA methylation and its potential role in gene control during development, aging and cancer has been hampered by a lack of sensitive methods which can resolve exact methylation patterns from only small quantities of DNA. We have now developed a genomic sequencing technique which is capable of detecting every methylated cytosine on ...
S J, Clark, J, Harrison, C L, Paul, M, Frommer   +3 more
openaire   +2 more sources

Cytosine methylation alteration in natural populations of Leymus chinensis induced by multiple abiotic stresses. [PDF]

PLoS ONE, 2013
BACKGROUND: Human activity has a profound effect on the global environment and caused frequent occurrence of climatic fluctuations. To survive, plants need to adapt to the changing environmental conditions through altering their morphological and ...
Yingjie Yu, Xuejiao Yang, Huaying Wang, Fengxue Shi, Ying Liu, Jushan Liu, Linfeng Li, Deli Wang, Bao Liu   +8 more
doaj   +1 more source

The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis [PDF]

, 2015
A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear.
Robert J. Schmitz, Chad E. Niederhuth, Ooi, Steen KT, Stathopoulou, A, Richard G. Jenner, Steen K.T. Ooi, de Rooij, Dirk G, Tuna, Salih, Vlachogiannis, Georgios, Niederhuth, CE, Viiri, Keijo, Niederhuth, Chad E, Schmitz, RJ, Jenner, Richard G., Jenner, Richard G,, Vlachogiannis, G, Keijo Viiri, Tuna, S, Ooi, SK, Stathopoulou, Athanasia, Jenner, RG, Ooi, Steen K.T., de Rooij, DG, Dirk G. de Rooij, Schmitz, Robert J, de Rooij, Dirk G., Athanasia Stathopoulou, Salih Tuna, Niederhuth, Chad E., Schmitz, Robert J., Viiri, K, Ooi, Steen K. T., Georgios Vlachogiannis   +32 more
core   +1 more source

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions

BMC Plant Biology, 2017
Background Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or during
Martin Schmidt, Michiel Van Bel, Magdalena Woloszynska, Bram Slabbinck, Cindy Martens, Marc De Block, Frederik Coppens, Mieke Van Lijsebettens   +7 more
doaj   +1 more source

Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. [PDF]

, 2011
Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the SRA domain of Uhrf1, an essential
Frauer, C., M. Cristina Cardoso, Leonhardt, Heinrich, Frauer, Carina, Bultmann, Sebastian, Casa, V., Valentina Casa, Frauer Carina, Hoffmann, T., Cardoso, M. Cristina, Leonhardt Heinrich, Antes, I., Casa Valentina, Iris Antes, Leonhart, H., Heinrich Leonhardt, Cardoso M. Cristina, Hoffmann Thomas, Hoffmann, Thomas, Antes Iris, Thomas Hoffmann, M Cristina Cardoso, Bultmann Sebastian, Bultmann, S., Antes, Iris, Casa, Valentina, Carina Frauer, Sebastian Bultmann   +27 more
core   +1 more source

Dynamic bimodal changes in CpG and non-CpG methylation genome-wide upon CGGBP1 loss-of-function

BMC Research Notes, 2018
Objectives Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine methylation regulatory
Divyesh Patel, Manthan Patel, Bengt Westermark, Umashankar Singh   +3 more
doaj   +1 more source

Dynamics of Methylated Cytosine Flipping by UHRF1 [PDF]

Journal of the American Chemical Society, 2017
DNA methylation patterns, which are critical for gene expression, are replicated by DNA methyltransferase 1 (DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins. This replication is initiated by the recognition of hemimethylated CpG sites and further flipping of methylated cytosines (mC) by the Set and Ring Associated ...
Bronner, Christian, Kilin, Vasyl, Gavvala, Krishna, Barthes, Nicolas, Michel, Benoît, Shin, Dongwon, Boudier, Christian, Mauffret, Olivier, Yashchuk, Valeriy, Mousli, Marc, Ruff, Marc, Granger, Florence, Eiler, Sylvia, Tor, Yitzhak, Burger, Alain, Mély, Yves   +15 more
openaire   +5 more sources

Cytosine methylation of the sequence GATC in a mycoplasma [PDF]

Journal of Bacteriology, 1982
Mycoplasma virus L2 is subject to host-specific restriction and modification in Acholeplasma laidlawii strains JA1 and K2. We have examined the DNAs from both host cells and viruses propagated on these strains with respect to susceptibility to cleavage by restriction endonucleases and for DNA base modifications.
K, Dybvig, D, Swinton, J, Maniloff, S, Hattman   +3 more
openaire   +2 more sources