Results 1 to 10 of about 89 (65)

CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity

BMC Genetics, 2020
Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Manthan Patel, Divyesh Patel, Subhamoy Datta   +2 more
exaly   +4 more sources

CGGBP1 regulates CTCF occupancy at repeats

Epigenetics and Chromatin, 2019
Background CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of histone-modifying enzymes and as a
Divyesh Patel, Manthan Patel, Subhamoy Datta   +2 more
exaly   +4 more sources

A DNA Sequence Directed Mutual Transcription Regulation of HSF1 and NFIX Involves Novel Heat Sensitive Protein Interactions [PDF]

PLoS ONE, 2009
BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh, Erik Bongcam-Rudloff, B Westermark   +2 more
exaly   +3 more sources

The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

BMC Genomic Data
CGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation.
Subhamoy Datta, Umashankar Singh, Singh Umashankar   +2 more
exaly   +3 more sources

The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress

EMBO Reports
The CGG triplet repeat binding protein 1 (CGGBP1) binds to CGG repeats and has several important cellular functions, but how this DNA sequence-specific binding factor affects transcription and replication processes is an open question. Here, we show that
Maxime Lalonde, Stefanie M Hauck, Stephan Hamperl   +2 more
exaly   +3 more sources

CGGBP1-dependent CTCF-binding sites restrict ectopic transcription [PDF]

Cell Cycle, 2021
Binding sites of the chromatin regulator protein CTCF function as important landmarks in the human genome. The recently characterized CTCF-binding sites at LINE-1 repeats depend on another repeat-regulatory protein CGGBP1.
Divyesh Patel, Manthan Patel, Subhamoy Datta   +2 more
exaly   +3 more sources

CGGBP1 regulates cell cycle in cancer cells [PDF]

BMC Molecular Biology, 2011
Background: CGGBP1 is a CGG-triplet repeat binding protein, which affects transcription from CGG-triplet-rich promoters such as the FMR1 gene and the ribosomal RNA gene clusters.
Umashankar Singh, Pernilla Roswall, Lene Uhrbom   +2 more
exaly   +2 more sources

CGGBP1 mitigates cytosine methylation at repetitive DNA sequences [PDF]

BMC Genomics, 2015
Background: CGGBP1 is a repetitive DNA-binding transcription regulator with target sites at CpG-rich sequences such as CGG repeats and Alu-SINEs and L1-LINEs. The role of CGGBP1 as a possible mediator of CpG methylation however remains unknown.
Prasoon Agarwal, Markus Hsi-Yang Fritz, Vladimir Benes   +2 more
exaly   +3 more sources

An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1

BMC Cancer, 2020
Background Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins.
Manthan Patel, Divyesh Patel, Subhamoy Datta   +2 more
exaly   +3 more sources

CGGBP1 is a nuclear and midbody protein regulating abscission

Experimental Cell Research, 2011
Abscission marks the completion of cell division and its failure is associated with delayed cytokinesis and even tetraploidization. Aberrant abscission and consequential ploidy changes can underlie various diseases including cancer.
Umashankar Singh, B Westermark
exaly   +2 more sources