CGGBP1-Regulated Cytosine Methylation at CTCF-Binding Motifs Resists Stochasticity [PDF]
BMC Genetics, 2020 Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Umashankar Singh +2 more
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CGGBP1 Regulates CTCF Occupancy at Repeats [PDF]
Epigenetics and Chromatin, 2019 Background CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of histone-modifying enzymes and as a
Umashankar Singh +2 more
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The Amniote-Conserved DNA-Binding Domain of CGGBP1 Restricts Cytosine Methylation of Transcription Factor Binding Sites in Proximal Promoters to Regulate Gene Expression [PDF]
BMC Genomic DataCGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation.
Umashankar Singh
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The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress [PDF]
EMBO ReportsThe CGG triplet repeat binding protein 1 (CGGBP1) binds to CGG repeats and has several important cellular functions, but how this DNA sequence-specific binding factor affects transcription and replication processes is an open question. Here, we show that
Henning Ummethum +14 more
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An Immunochemistry-Based Screen for Chemical Inhibitors of DNA-Protein Interactions and Its Application to Human CGGBP1 [PDF]
BMC Cancer, 2020 Background Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins.
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Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression [PDF]
Frontiers in AgingBackgroundSkin aging is characterized by observable major changes in the composition and organization of the skin, including the appearance of wrinkles, tissue sagging, dryness, and pigmentary disorders.
Ludivine Obry +13 more
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Dynamic Bimodal Changes in CpG and Non-CpG Methylation Genome-Wide Upon CGGBP1 Loss-of-Function [PDF]
BMC Research Notes, 2018 Objectives Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine methylation regulatory
Bengt Westermark +2 more
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CGGBP1-Dependent CTCF-Binding Sites Restrict Ectopic Transcription [PDF]
Cell Cycle, 2021 Binding sites of the chromatin regulator protein CTCF function as important landmarks in the human genome. The recently characterized CTCF-binding sites at LINE-1 repeats depend on another repeat-regulatory protein CGGBP1.
Umashankar Singh +2 more
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CGGBP1 From Higher Amniotes Restricts Cytosine Methylation and Drives a GC-Bias in Transcription Factor-Binding Sites at Repressed Promoters [PDF]
TranscriptionCGGBP1, a 20 kDa protein, has several functions associated with its DNA-binding through a C2H2 zinc finger. A range of studies have shown that GC richness, inter-strand G/C-skew and low cytosine methylation are associated with CGGBP1 occupancy.
Umashankar Singh
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Growth Signals Employ CGGBP1 to Suppress Transcription of Alu-SINEs [PDF]
Cell Cycle, 2016 CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response,cytokinesis, telomeric integrity and transcription. It could affect these processes by modulatingtarget gene expression under different conditions. Identification
Bengt Westermark +2 more
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