Results 1 to 10 of about 29 (24)

CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity

BMC Genetics, 2020
Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Umashankar Singh, Divyesh Patel, Manthan Patel   +2 more
exaly   +3 more sources

CGGBP1 regulates CTCF occupancy at repeats

Epigenetics and Chromatin, 2019
Background CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of histone-modifying enzymes and as a
Umashankar Singh, Divyesh Patel, Manthan Patel   +2 more
exaly   +3 more sources

Dynamic bimodal changes in CpG and non-CpG methylation genome-wide upon CGGBP1 loss-of-function

BMC Research Notes, 2018
Objectives Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine methylation regulatory
Bengt Westermark, Umashankar Singh, Divyesh Patel   +2 more
exaly   +3 more sources

An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1

BMC Cancer, 2020
Background Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins.
Umashankar Singh, Divyesh Patel, Manthan Patel   +2 more
exaly   +3 more sources

The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

BMC Genomic Data
CGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation.
Umashankar Singh, Singh Umashankar
exaly   +2 more sources

A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]

PLoS ONE, 2009
BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh, Erik Bongcam-Rudloff, Bengt Westermark   +2 more
doaj   +1 more source

Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression

Frontiers in Aging
BackgroundSkin aging is characterized by observable major changes in the composition and organization of the skin, including the appearance of wrinkles, tissue sagging, dryness, and pigmentary disorders.
Ludivine Obry, Raissa Medina-Santos, Myriam Rahmouni, Josselin Noirel, Toufik Labib, Pilar Galan, Jean-Louis Spadoni, Gaëlle Gendronneau, Randa Jdid, Sandra Courrèges, Julie Latreille, Nada André, Jean-François Zagury, Sigrid Le Clerc   +13 more
doaj   +1 more source

Identification of CircRNA Complexes Acting on miRNA Sponges within the Exosome in Patients with Alzheimer’s Disease: An In Silico Approach

Bezmiâlem Science
Objective: Alzheimer’s disease (AD) is a neurodegenerative ailment that launches insidiously and progresses slowly, and its prevalence gradually increases with age.
Rabia KALKAN CAKMAK, Nail BESLI, Bahar SARIKAMIS JOHNSON, Nilufer ERCIN, Hayati Sencer POLAT, Ulkan KILIC   +5 more
doaj   +1 more source

The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress

EMBO Reports
The CGG triplet repeat binding protein 1 (CGGBP1) binds to CGG repeats and has several important cellular functions, but how this DNA sequence-specific binding factor affects transcription and replication processes is an open question. Here, we show that
Henning Ummethum, Augusto C Murriello, Marcel Werner, Elizabeth Márquez-Gómez, Ann-Christine König, Elisabeth Kruse, Maxime Lalonde, Manuel Trauner, Anna Chanou, Matthias Weiβ, Clare S K Lee, Andreas Ettinger, Florian Erhard, Stefanie M Hauck, Stephan Hamperl   +14 more
doaj   +1 more source

CGGBP1-dependent CTCF-binding sites restrict ectopic transcription

Cell Cycle, 2021
Umashankar Singh, Subhamoy Datta, Divyesh Patel   +2 more
exaly