Dynamic bimodal changes in CpG and non-CpG methylation genome-wide upon CGGBP1 loss-of-function [PDF]
BMC Research Notes, 2018 Objectives Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine methylation regulatory
Divyesh Patel +2 more
exaly +6 more sources
Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs [PDF]
Cell Cycle, 2016 CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response,cytokinesis, telomeric integrity and transcription. It could affect these processes by modulatingtarget gene expression under different conditions. Identification
Prasoon Agarwal +2 more
exaly +6 more sources
Identification of gene–sun exposure interactions of GWAS-identified variants in perceived facial aging progression [PDF]
Frontiers in AgingBackgroundSkin aging is characterized by observable major changes in the composition and organization of the skin, including the appearance of wrinkles, tissue sagging, dryness, and pigmentary disorders.
Ludivine Obry +13 more
doaj +3 more sources
Defining the role of the CGGBP1 protein in FMR1 gene expression [PDF]
European Journal of Human Genetics, 2016 Fragile X syndrome is the most common heritable form of intellectual disability and is caused by the expansion over 200 repeats and subsequent methylation of the CGG triplets at the 5′ UTR of the FMR1 gene, leading to its silencing.
Neri, Giovanni +13 more
core +5 more sources
CGGBP1 phosphorylation constitutes a telomere-protection signal [PDF]
Cell Cycle, 2013 The shelterin proteins are required for telomere integrity. Shelterin dysfunction can lead to initiation of unwarranted DNA damage and repair pathways at chromosomal termini.
Maturi, Varun, +11 more
core +5 more sources
CGGBP1-an indispensable protein with ubiquitous cytoprotective functions [PDF]
Upsala Journal of Medical Sciences, 2015 The human genome contains multiple stretches of CGG trinucleotide repeats, which act as transcription- and translation-regulatory elements but at the same time form secondary structures that impede replication and give rise to sites of chromosome ...
Singh, Umashankar +3 more
core +5 more sources
Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 [PDF]
Oncotarget, 2022 Peer ...
Patel, Manthan +9 more
core +7 more sources
TranscriptionCGGBP1, a 20 kDa protein, has several functions associated with its DNA-binding through a C2H2 zinc finger. A range of studies have shown that GC richness, inter-strand G/C-skew and low cytosine methylation are associated with CGGBP1 occupancy.
Subhamoy Datta, Umashankar Singh
exaly +4 more sources
Differential expression of CGGBP1 in amyotrophic lateral sclerosis.
, 2022 Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2).
Shahan Mamoor
core +2 more sources
Gestational Valproate Exposure Induces Tissue‐Specific Transcriptomic Changes in the Neonatal Brain and Choroid Plexus in a Rat Model of Epilepsy, GAERS [PDF]
European Journal of Neuroscience, Volume 61, Issue 10, May 2025.This study used a rat model of absence epilepsy, Genetic Absence Epilepsy Rat from Strasbourg (GAERS), to investigate the effects of gestational valproate exposure on early postnatal brain cortex and lateral choroid plexus transcriptomes. Results showed distinct differential gene expression patterns between the two tissues, with substantially more ...
Fiona Qiu +4 more
wiley +2 more sources