Results 11 to 20 of about 91 (71)
CGGBP1-dependent CTCF-binding sites restrict ectopic transcription [PDF]
Cell Cycle, 2020 Abstract Binding sites of the chromatin regulator protein CTCF function as important landmarks in the human genome. The recently characterized CTCF-binding sites at LINE-1 repeats depend on another repeat-regulatory protein CGGBP1. These CGGBP1-dependent CTCF-binding sites serve as potential barrier elements for epigenetic marks such as
Divyesh Patel +3 more
openaire +3 more sources
CGGBP1 phosphorylation constitutes a telomere-protection signal [PDF]
Cell Cycle, 2013 The shelterin proteins are required for telomere integrity. Shelterin dysfunction can lead to initiation of unwarranted DNA damage and repair pathways at chromosomal termini. Interestingly, many shelterin accessory proteins are involved in DNA damage signaling and repair.
Singh U +5 more
openaire +3 more sources
Dissecting Heterogeneity Reveals a Unique BAMBIhighMFGE8high Subpopulation of Human UC‐MSCs
Advanced Science, Volume 10, Issue 1, January 4, 2023., 2023 Large‐scale scRNA‐seq uncovers a unique BAMBIhighMFGE8high subpopulation hidden in heterogeneous human UC‐MSCs. It has special features in terms of phenotype, distinct transcriptomic profile, limited adipogenic differentiation potential, and unconventional immunological properties.
Hongwei Chen +10 more
wiley +1 more source
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 119, Issue 3, Page 868-880, March 2022., 2022 Targeted locus amplification (TLA) allows for accurate transgene integration site detection of CHO clones. Further, it provides comprehensive genetic information of the transgene locus including genomic rearrangements, deletions and translocations. Genes within or in close proximity to the integration site can be identified, which can have important ...
Anna Stadermann +7 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes and reveal its molecular mechanism. In order to explore the potential facts for gastric cancer, the expression profiles of two different datasets were used (GSE161533 and ...
Arulprakasam Ajucarmelprecilla +16 more
wiley +1 more source
Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs [PDF]
Cell Cycle, 2014 CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response, cytokinesis, telomeric integrity and transcription. It could affect these processes by modulating target gene expression under different conditions. Identification of CGGBP1-target genes and their regulation could reveal how a transcription regulator affects ...
Agarwal, Prasoon +6 more
openaire +3 more sources
CGGBP1—an indispensable protein with ubiquitous cytoprotective functions
Upsala Journal of Medical Sciences, 2015 The human genome contains multiple stretches of CGG trinucleotide repeats, which act as transcription- and translation-regulatory elements but at the same time form secondary structures that impede replication and give rise to sites of chromosome fragility.
Singh U, Westermark B
openaire +3 more sources
HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1 [PDF]
, 2020 Abstract The antineoplastic agent Givinostat inhibits histone deacetylases. We present here our finding that the DNA-binding of human CGGBP1 is also inhibited by Givinostat. CGGBP1, a DNA-binding protein, is required for cancer cell proliferation.
Manthan Patel +3 more
openaire +2 more sources
Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1 [PDF]
Oncotarget, 2021 ABSTRACT Genomes of somatic cells in culture are prone to spontaneous mutations due to errors in replication and DNA repair. Some of these errors, such as chromosomal fusions, are not rectifiable and subject to selection or elimination in growing cultures. Somatic cell cultures are thus expected to generate background
Subhamoy Datta +4 more
openaire +4 more sources