Results 11 to 20 of about 278 (93)
CGGBP1 Mitigates Cytosine Methylation at Repetitive DNA Sequences [PDF]
BMC Genomics, 2015 Background: CGGBP1 is a repetitive DNA-binding transcription regulator with target sites at CpG-rich sequences such as CGG repeats and Alu-SINEs and L1-LINEs. The role of CGGBP1 as a possible mediator of CpG methylation however remains unknown.
Bengt Westermark +2 more
exaly +5 more sources
A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]
PLoS ONE, 2009 BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh +2 more
doaj +2 more sources
Defining the Role of the CGGBP1 Protein in FMR1 Gene Expression [PDF]
European Journal of Human Genetics, 2016 Fragile X syndrome is the most common heritable form of intellectual disability and is caused by the expansion over 200 repeats and subsequent methylation of the CGG triplets at the 5′ UTR of the FMR1 gene, leading to its silencing.
Pietro Chiurazzi +2 more
exaly +3 more sources
CGGBP1—An Indispensable Protein With Ubiquitous Cytoprotective Functions [PDF]
Upsala Journal of Medical Sciences, 2015 The human genome contains multiple stretches of CGG trinucleotide repeats, which act as transcription- and translation-regulatory elements but at the same time form secondary structures that impede replication and give rise to sites of chromosome ...
Bengt Westermark, Umashankar Singh
exaly +3 more sources
Gestational Valproate Exposure Induces Tissue-Specific Transcriptomic Changes in the Neonatal Brain and Choroid Plexus in a Rat Model of Epilepsy, GAERS. [PDF]
Eur J NeurosciThis study used a rat model of absence epilepsy, Genetic Absence Epilepsy Rat from Strasbourg (GAERS), to investigate the effects of gestational valproate exposure on early postnatal brain cortex and lateral choroid plexus transcriptomes. Results showed distinct differential gene expression patterns between the two tissues, with substantially more ...
Qiu F +4 more
europepmc +2 more sources
Dissecting Heterogeneity Reveals a Unique BAMBIhighMFGE8high Subpopulation of Human UC‐MSCs
Advanced Science, Volume 10, Issue 1, January 4, 2023., 2023 Large‐scale scRNA‐seq uncovers a unique BAMBIhighMFGE8high subpopulation hidden in heterogeneous human UC‐MSCs. It has special features in terms of phenotype, distinct transcriptomic profile, limited adipogenic differentiation potential, and unconventional immunological properties.
Hongwei Chen +10 more
wiley +1 more source
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 119, Issue 3, Page 868-880, March 2022., 2022 Targeted locus amplification (TLA) allows for accurate transgene integration site detection of CHO clones. Further, it provides comprehensive genetic information of the transgene locus including genomic rearrangements, deletions and translocations. Genes within or in close proximity to the integration site can be identified, which can have important ...
Anna Stadermann +7 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes and reveal its molecular mechanism. In order to explore the potential facts for gastric cancer, the expression profiles of two different datasets were used (GSE161533 and ...
Arulprakasam Ajucarmelprecilla +16 more
wiley +1 more source
Expanding the Spectrum of Canine Diffuse Large B-Cell Lymphoma Genetic Aberrations Through Whole Genome Sequencing Analysis. [PDF]
Vet Comp OncolABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is one of the most prevalent haematological malignancies in both humans and dogs, characterised in both species by significant clinical heterogeneity and limited prognostic predictability. With the introduction of next‐generation sequencing (NGS) technologies in veterinary medicine over the past decade ...
Fanelli A +4 more
europepmc +2 more sources