Results 21 to 30 of about 278 (93)

An Age‐Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice

Neural Plasticity, Volume 2020, Issue 1, 2020., 2020
Inbred mouse models are widely used to study age‐related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function—protective genes that confer strong resistance to hearing loss.
Qing Yin Zheng, Lihong Kui, Fuyi Xu, Tihua Zheng, Bo Li, Melinda McCarty, Zehua Sun, Aizheng Zhang, Luying Liu, Athena Starlard-Davenport, Ruben Stepanyan, Bo Hua Hu, Lu Lu, Renjie Chai   +13 more
wiley   +1 more source

A Genome‐Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients

Journal of Diabetes Research, Volume 2020, Issue 1, 2020., 2020
Long noncoding RNAs (lncRNAs) regulate gene expression at different levels in various diseases, including type 1 diabetes (T1D). However, the expression of circulating lncRNAs in leukocytes in T1D has not been well documented. To identify differentially expressed lncRNAs between T1D patients and healthy controls, RNA sequencing was performed on samples
Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen, Bernd Stratmann   +11 more
wiley   +1 more source

Differential expression of CGGBP1 in amyotrophic lateral sclerosis.

, 2022
Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2).
Shahan Mamoor
core   +1 more source

HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

, 2020
The antineoplastic agent Givinostat inhibits histone deacetylases. We present here our finding that the DNA-binding of human CGGBP1 is also inhibited by Givinostat. CGGBP1, a DNA-binding protein, is required for cancer cell proliferation. In our quest to
Patel, Manthan, Singh, Umashankar, Datta, Subhamoy, Patel, Divyesh   +3 more
core   +1 more source

Bioinformatic screening for key miRNAs and genes associated with myocardial infarction

FEBS Open Bio, Volume 8, Issue 6, Page 897-913, June 2018., 2018
Treatment of myocardial infarction (MI) has improved in recent years, but morbidity and mortality is still high. In this study, we used bioinformatics techniques to identify miRNA and genes potentially associated with MI, validating these results by quantitative RT‐PCR.
Ke Wu, Qiang Zhao, Zhengmei Li, Nannan Li, Qiang Xiao, Xiuchang Li, Quanming Zhao   +6 more
wiley   +1 more source

Identification of Novel Epigenetic Markers of Prostate Cancer by NotI‐Microarray Analysis

Disease Markers, Volume 2015, Issue 1, 2015., 2015
A significant need for reliable and accurate cancer diagnostics and prognosis compels the search for novel biomarkers that would be able to discriminate between indolent and aggressive tumors at the early stages of disease. The aim of this work was identification of potential diagnostic biomarkers for characterization of different types of prostate ...
Alexey A. Dmitriev, Eugenia E. Rosenberg, George S. Krasnov, Ganna V. Gerashchenko, Vasily V. Gordiyuk, Tatiana V. Pavlova, Anna V. Kudryavtseva, Artemy D. Beniaminov, Anastasia A. Belova, Yuriy N. Bondarenko, Rostislav O. Danilets, Alexander I. Glukhov, Aleksandr G. Kondratov, Andrey Alexeyenko, Boris Y. Alekseev, George Klein, Vera N. Senchenko, Vladimir I. Kashuba, Stamatios Theocharis   +18 more
wiley   +1 more source

Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs

, 2014
CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response, cytokinesis, telomeric integrity and transcription.
Arian Smit (664273), Martin Teichmann (664271), Prasoon Agarwal (246053), Umashankar Singh (265945), Stefan Enroth (189126), Bengt Westermark (265947), Helena Jernberg Wiklund (664272)   +6 more
core   +1 more source

Polymorphisms in twelve candidate genes are associated with growth, muscle lipid profile and meat quality traits in eleven European cattle breeds

, 2014
Current customers' demands focus on the nutritional and sensory quality of cattle meat. Candidate gene approach allows identification of genetic polymorphisms that have a measurable effect on traits of interest.
Others, 23, Others, Six, Sevane, N., Nute, Geoffrey, Richardson, Ian   +4 more
core   +4 more sources

Single‐nucleus and spatial transcriptome reveal adrenal homeostasis in normal and tumoural adrenal glands

Clinical and Translational Medicine, Volume 14, Issue 8, August 2024.
This study unveils the cellular diversity within the adult human adrenal gland using single‐nuclei RNA sequencing and spatial transcriptome data. Analysis of the adult human adrenal gland identifies new cell populations and key pathways governing adrenal homeostasis.
Barbara Altieri, A. Kerim Secener, Somesh Sai, Cornelius Fischer, Silviu Sbiera, Panagiota Arampatzi, Stefan Kircher, Sabine Herterich, Laura‐Sophie Landwehr, Sarah N. Vitcetz, Caroline Braeuning, Martin Fassnacht, Cristina L. Ronchi, Sascha Sauer   +13 more
wiley   +1 more source

Identification of CircRNA Complexes Acting on miRNA Sponges within the Exosome in Patients with Alzheimer’s Disease: An In Silico Approach

Bezmiâlem Science
Objective: Alzheimer’s disease (AD) is a neurodegenerative ailment that launches insidiously and progresses slowly, and its prevalence gradually increases with age.
Rabia KALKAN CAKMAK, Nail BESLI, Bahar SARIKAMIS JOHNSON, Nilufer ERCIN, Hayati Sencer POLAT, Ulkan KILIC   +5 more
doaj   +1 more source