Results 41 to 50 of about 62,191 (286)

Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase

, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
Stier, Ildikó, Antal Kiss (474840), Ildikó Stier, Antal Kiss, Kiss, Antal, Ildikó Stier (474839)   +5 more
core   +1 more source

Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.

PLoS Genetics, 2014
Epigenetic marks such as cytosine methylation are important determinants of cellular and whole-body phenotypes. However, the extent of, and reasons for inter-individual differences in cytosine methylation, and their association with phenotypic variation ...
Michelle D Johnson, Michael Mueller, Martyna Adamowicz-Brice, Melissa J Collins, Pascal Gellert, Klio Maratou, Prashant K Srivastava, Maxime Rotival, Shahena Butt, Laurence Game, Santosh S Atanur, Nicholas Silver, Penny J Norsworthy, Sarah R Langley, Enrico Petretto, Michal Pravenec, Timothy J Aitman   +16 more
doaj   +1 more source

Methylation Status of Imprinted Genes and Repetitive Elements in Sperm DNA from Infertile Males [PDF]

, 2011
Stochastic, environmentally and/or genetically induced disturbances in the genome-wide epigenetic reprogramming processes during male germ-cell development may contribute to male infertility.
Tresch, A., N. El Hajj, M. Schorsch, Haaf, T., Hahn, T., U. Zechner, E. Schneider, T. Hahn, T. Haaf, El Hajj, N., Gromoll, J., Schorsch, M., A. Tresch, Schneider, E., Zechner, Ulrich, J. Gromoll   +15 more
core   +1 more source

5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m5C formation catalyzed by RNA methyltransferase

BMC Research Notes, 2022
Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj   +1 more source

Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase [PDF]

, 1991
Mammalian DNA cytosine-5-methyltransferase (MTase, EC 2.1.1.37) is an essential component for establishing and maintaining cell-type specific methylation patterns in the genome. The cDNAfor the murine enzyme was previously cloned in segments.
Häuselmann, Remo, Bestor, Timothy H., Bestor, T. H., Page, A. W., Page, Andrea W., Hergersberg, M., Leonhardt, Heinrich, Häuselmann, R., Czank, A., Czank, Andreas, Schaffner, Walter, Schaffner, W., Hergersberg, Martin, Leonhardt, H.   +13 more
core   +1 more source

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Nature Communications, 2018
In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome.
Matt Teater, Pilar M. Dominguez, David Redmond, Zhengming Chen, Daisuke Ennishi, David W. Scott, Luisa Cimmino, Paola Ghione, Jayanta Chaudhuri, Randy D. Gascoyne, Iannis Aifantis, Giorgio Inghirami, Olivier Elemento, Ari Melnick, Rita Shaknovich   +14 more
doaj   +1 more source

Transcriptional silencing of 35S driven-transgene is differentially determined depending on promoter methylation heterogeneity at specific cytosines in both plus- and minus-sense strands

BMC Plant Biology, 2019
Background De novo DNA methylation triggered by short interfering RNAs is called RNA-directed DNA methylation (RdDM). Transcriptional gene silencing (TGS) through RdDM can be induced using a viral vector.
Wataru Matsunaga, Hanako Shimura, Senri Shirakawa, Reika Isoda, Tsuyoshi Inukai, Takeshi Matsumura, Chikara Masuta   +6 more
doaj   +1 more source

Sodium Azide as a Chemical Mutagen in Wheat (Triticum aestivum L.): Patterns of the Genetic and Epigenetic Effects with iPBS and CRED-iPBS Techniques

Agriculture, 2023
Wheat, which is scientifically known as Triticum aestivum L., is a very nutritious grain that serves as a key component of the human diet. The use of mutation breeding as a tool for crop improvement is a reasonably rapid procedure, and it generates a ...
Aras Türkoğlu, Kamil Haliloğlu, Metin Tosun, Piotr Szulc, Fatih Demirel, Barış Eren, Henryk Bujak, Halit Karagöz, Marek Selwet, Güller Özkan, Gniewko Niedbała   +10 more
doaj   +1 more source

Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican   +18 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source