Results 41 to 50 of about 254,703 (199)

5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m5C formation catalyzed by RNA methyltransferase

BMC Research Notes, 2022
Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj   +1 more source

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Nature Communications, 2018
In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome.
Matt Teater, Pilar M. Dominguez, David Redmond, Zhengming Chen, Daisuke Ennishi, David W. Scott, Luisa Cimmino, Paola Ghione, Jayanta Chaudhuri, Randy D. Gascoyne, Iannis Aifantis, Giorgio Inghirami, Olivier Elemento, Ari Melnick, Rita Shaknovich   +14 more
doaj   +1 more source

Transcriptional silencing of 35S driven-transgene is differentially determined depending on promoter methylation heterogeneity at specific cytosines in both plus- and minus-sense strands

BMC Plant Biology, 2019
Background De novo DNA methylation triggered by short interfering RNAs is called RNA-directed DNA methylation (RdDM). Transcriptional gene silencing (TGS) through RdDM can be induced using a viral vector.
Wataru Matsunaga, Hanako Shimura, Senri Shirakawa, Reika Isoda, Tsuyoshi Inukai, Takeshi Matsumura, Chikara Masuta   +6 more
doaj   +1 more source

Sodium Azide as a Chemical Mutagen in Wheat (Triticum aestivum L.): Patterns of the Genetic and Epigenetic Effects with iPBS and CRED-iPBS Techniques

Agriculture, 2023
Wheat, which is scientifically known as Triticum aestivum L., is a very nutritious grain that serves as a key component of the human diet. The use of mutation breeding as a tool for crop improvement is a reasonably rapid procedure, and it generates a ...
Aras Türkoğlu, Kamil Haliloğlu, Metin Tosun, Piotr Szulc, Fatih Demirel, Barış Eren, Henryk Bujak, Halit Karagöz, Marek Selwet, Güller Özkan, Gniewko Niedbała   +10 more
doaj   +1 more source

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria [PDF]

Proceedings of the National Academy of Sciences, 2011
Mitochondrial DNA (mtDNA) has been reported to contain 5-methylcytosine (5mC) at CpG dinucleotides, as in the nuclear genome, but neither the mechanism generating mtDNA methylation nor its functional significance is known. We now report the presence of 5-hydroxymethylcytosine (5hmC) as well as 5mC in mammalian mtDNA, suggesting that previous studies ...
Lisa S, Shock, Prashant V, Thakkar, Erica J, Peterson, Richard G, Moran, Shirley M, Taylor   +4 more
openaire   +2 more sources

Cytosine DNA Methylation.

, 2014
Cytosine DNA methylation is a epigenetic mechanisms that affects gene expression. It involves the addition of a methyl group to the cytosine DNA nucleotides.
Luciano Milanesi (28769), Giuliano Armano (28767), Andrea Manconi (566020), Emanuele Manca (566021), Alessandro Orro (28770)   +4 more
core   +1 more source

High-resolution analysis of cytosine methylation in ancient DNA. [PDF]

PLoS ONE, 2012
Epigenetic changes to gene expression can result in heritable phenotypic characteristics that are not encoded in the DNA itself, but rather by biochemical modifications to the DNA or associated chromatin proteins. Interposed between genes and environment,
Bastien Llamas, Michelle L Holland, Kefei Chen, Jennifer E Cropley, Alan Cooper, Catherine M Suter   +5 more
doaj   +1 more source

In planta assays involving epigenetically silenced genes reveal inhibition of cytosine methylation by genistein

Plant Methods, 2012
Background Cytosine methylation is involved in epigenetic control of gene expression in a wide range of organisms. An increasing number of examples indicate that changing the frequency of cytosine methylation in the genome is a feasible tool to engineer ...
Arase Sachiko, Kasai Megumi, Kanazawa Akira   +2 more
doaj   +1 more source

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Gut, IG, Tost, J, Fischer, J, Hildmann, T, Lewin, J, Novik, KL, Beck, S, Cox, AV, Olek, A, Berlin, K, Otto, T, Howe, KL, Andrews, TD, Rakyan, VK   +13 more
core  

Evidence Suggesting Absence of Mitochondrial DNA Methylation

Frontiers in Genetics, 2017
Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation of mitochondria function. The existence of cytosine methylation in the mitochondrial genome is debated.
Mie Mechta, Lars R. Ingerslev, Odile Fabre, Martin Picard, Romain Barrès   +4 more
doaj   +1 more source