Results 61 to 70 of about 57,661 (242)
Scientific Reports, 2018 Streptomyces coelicolor is a Gram-positive microorganism often used as a model of physiological and morphological differentiation in streptomycetes, prolific producers of secondary metabolites with important biological activities.
Annalisa Pisciotta +2 more
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DNA methylation and mRNA expression of
BMC Medical Genetics, 2008 Background The synapsin III (SYN III) gene on chromosome 22q is a candidate gene for schizophrenia susceptibility due to its chromosome location, neurological function, expression patterns and functional polymorphisms.
Singh Shiva M +2 more
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Cytosine methylation alters DNA mechanical properties [PDF]
Nucleic Acids Research, 2011 DNA methylation plays an essential role in transcriptional control of organismal development in epigenetics, from turning off a specific gene to inactivation of entire chromosomes. While the biological function of DNA methylation is becoming increasingly clear, the mechanism of methylation-induced gene regulation is still poorly understood.
Severin, Philip M. D. +3 more
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Advanced Science, EarlyView.CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas +13 more
wiley +1 more source
Biomolecular Concepts, 2010 Numerous epigenetic modifications have been identified and correlated with transcriptionally active euchromatin or repressed heterochromatin and many enzymes responsible for the addition and removal of these marks have been characterized.
Skalnik David G.
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The effects of cytosine methylation on general transcription factors [PDF]
Scientific Reports, 2016 AbstractDNA methylation on CpG sites is the most common epigenetic modification. Recently, methylation in a non-CpG context was found to occur widely on genomic DNA. Moreover, methylation of non-CpG sites is a highly controlled process and its level may vary during cellular development.
Jianshi Jin +5 more
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Advanced Science, EarlyView.Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen +6 more
wiley +1 more source
BMC BiologyBackground Bacterial epigenetics is a rapidly expanding research field. DNA methylation by diverse bacterial methyltransferases (MTases) contributes to genomic integrity and replication, and many recent studies extended MTase function also to global ...
Lubna Patel +3 more
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PlantDeepMeth: A Deep Learning Model for Predicting DNA Methylation States in Plants
PlantsCytosine DNA methylation (5mCs) is an important epigenetic modification in genomic research. However, the methylation states of some cytosine sites are not available due to the limitations of different studies, and there are few tools developed to deal ...
Zhongwei Guo +6 more
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Investigation of the Influence of Cytosine Methylation on DNA Flexibility [PDF]
Journal of Biological Chemistry, 1995 To test the influence of pyrimidine methyl groups on DNA flexibility and helix repeat, two sets of 14 mixed sequence DNA molecules, spanning a range of lengths from 158 to 180 base pairs, were cyclized with T4 DNA ligase. The two sets differed only in that the Cyt-5 positions of all cytosines (80-90 cytosine residues per molecule) were fully methylated
Y, Hodges-Garcia, P J, Hagerman
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