Results 81 to 90 of about 62,191 (286)

Microsoft® Word™ Macro for Analysis of Cytosine Methylation by the Bisulfite Deamination Reaction

BioTechniques, 2001
Cytosine methylation at CpG dinucleotides is an important control mechanism in development, differentiation, and neoplasia. Bisulfite genomic sequencing and its modifications have been developed to examine methylation at these CpG dinucleotides.
Rakesh Singal, Sidney R. Grimes
doaj   +1 more source

Cytosine-Based TET Enzyme Inhibitors

, 2019
DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered ...
Beth G. Malachowsky (6298331), Martin Kruse (6298334), Kelly L. Wassarman (6298316), Joseph A. Alp (6298322), Emma I. Jarczyk (6298325), Gabriella N. L. Chua (6298313), Michael J. Bennett (172679), Andrew J. Kennedy (2196862), Nathanael J. Kuzio (6298328), Haoyu Sun (6298319)   +9 more
core   +1 more source

Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. [PDF]

, 2012
DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation.
Spada, Fabio, Zacher, Benedikt, Leonhardt, Heinrich, Bultmann, Sebastian, Daniela Meilinger, Heinrich Leonhardt (18589), Daniela Meilinger (107843), Schmidt, Christine S., Benedikt Zacher, Fabio Spada (107869), Kerstin C Maier, Martin, Dietmar E., Christine S. Schmidt (107838), Heinrich Leonhardt, Christian Peter, Peter, Christian, Christine S Schmidt, Dietmar E. Martin (107866), Achim Tresch, Fabio Spada, Benedikt Zacher (107847), Maier, Kerstin C., Tresch, Achim, Christian Peter (107860), Meilinger, Daniela, Achim Tresch (107851), Kerstin C. Maier (107856), Dietmar E Martin, Sebastian Bultmann (107841), Sebastian Bultmann   +29 more
core   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Tissue culture-induced transpositional activity of mPing is correlated with cytosine methylation in rice

BMC Plant Biology, 2009
Background mPing is an endogenous MITE in the rice genome, which is quiescent under normal conditions but can be induced towards mobilization under various stresses. The cellular mechanism responsible for modulating the activity of mPing remains unknown.
Pang Jinsong, Jiang Lily, Wang Hongyan, Xu Chunming, Ngezahayo Frédéric, Liu Bao   +5 more
doaj   +1 more source

DNA Methylation Alterations at 5'-CCGG Sites in the Interspecific and Intraspecific Hybridizations Derived from Brassica rapa and B. napus. [PDF]

PLoS ONE, 2013
DNA methylation is an important regulatory mechanism for gene expression that involved in the biological processes of development and differentiation in plants.
Wanshan Xiong, Xiaorong Li, Donghui Fu, Jiaqin Mei, Qinfei Li, Guanyuan Lu, Lunwen Qian, Yin Fu, Joseph Onwusemu Disi, Jiana Li, Wei Qian   +10 more
doaj   +1 more source

Frequencies and variation in cytosine methylation patterns in diploid and tetraploid cytotypes of Paspalum notatum

, 2012
Paspalum notatum Flügge is a grass species organized as an agamic complex. The objective of the current research was to survey the frequencies and variation of cytosine methylation at CCGG sequences in diploid and tetraploid genotypes, and to determine ...
C. L. Quarin, G. D. L. Cervigni, J. P. A. Ortiz, M. P. Rodriguez   +3 more
core   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

The SCO1731 methyltransferase modulates actinorhodin production and morphological differentiation of Streptomyces coelicolor A3(2)

Scientific Reports, 2018
Streptomyces coelicolor is a Gram-positive microorganism often used as a model of physiological and morphological differentiation in streptomycetes, prolific producers of secondary metabolites with important biological activities.
Annalisa Pisciotta, Angel Manteca, Rosa Alduina   +2 more
doaj   +1 more source