Results 91 to 100 of about 62,191 (286)

DNA methylation and mRNA expression of SYN III, a candidate gene for schizophrenia

BMC Medical Genetics, 2008
Background The synapsin III (SYN III) gene on chromosome 22q is a candidate gene for schizophrenia susceptibility due to its chromosome location, neurological function, expression patterns and functional polymorphisms.
Singh Shiva M, O'Reilly Richard L, Murphy Brenda C   +2 more
doaj   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

The epigenetic regulator Cfp1

Biomolecular Concepts, 2010
Numerous epigenetic modifications have been identified and correlated with transcriptionally active euchromatin or repressed heterochromatin and many enzymes responsible for the addition and removal of these marks have been characterized.
Skalnik David G.
doaj   +1 more source

Molecular genetic analysis of siRNA biogenesis and function in Arabidopsis thaliana [PDF]

, 2009
In diverse eukaryotes, small RNA products of Dicer-like (DCL) proteins regulate mRNA stability or translation, and direct chromatin modifications to genomic regions, phenomena collectively known as RNA silencing.
Blevins, Todd Lucas
core   +1 more source

Single-base resolution quantitative genome methylation analysis in the model bacterium Helicobacter pylori by enzymatic methyl sequencing (EM-Seq) reveals influence of strain, growth phase, and methyl homeostasis

BMC Biology
Background Bacterial epigenetics is a rapidly expanding research field. DNA methylation by diverse bacterial methyltransferases (MTases) contributes to genomic integrity and replication, and many recent studies extended MTase function also to global ...
Lubna Patel, Florent Ailloud, Sebastian Suerbaum, Christine Josenhans   +3 more
doaj   +1 more source

PlantDeepMeth: A Deep Learning Model for Predicting DNA Methylation States in Plants

Plants
Cytosine DNA methylation (5mCs) is an important epigenetic modification in genomic research. However, the methylation states of some cytosine sites are not available due to the limitations of different studies, and there are few tools developed to deal ...
Zhongwei Guo, Wenyuan Fan, Chengcheng Cai, Kang Zhang, Xilin Hou, Ying Li, Feng Cheng   +6 more
doaj   +1 more source

Bisulfighter: accurate detection of methylated cytosines and differentially methylated regions

Nucleic Acids Research, 2014
Abstract Analysis of bisulfite sequencing data usually requires two tasks: to call methylated cytosines (mCs) in a sample, and to detect differentially methylated regions (DMRs) between paired samples. Although numerous tools have been proposed for mC calling, methods for DMR detection have been largely limited.
Saito, Yutaka, Tsuji, Junko, Mituyama, Toutai   +2 more
openaire   +3 more sources

CpG-methylation regulates a class of Epstein-Barr virus promoters. [PDF]

, 2010
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian gene regulation. In general, cytosine-phosphatidyl-guanosine (CpG)-methylated promoters are transcriptionally repressed and nuclear proteins such as ...
Benet-Pagès, Anna, Christine Göbel, Göbel, C., Hammerschmidt, W., Wolfgang Hammerschmidt, Schmeinck Anne, Benet-Pagès Anna, Bergbauer Martin, Schmeinck, A., Eck Sebastian, Rothbauer, Ulrich, Strom, Tim M., Hammerschmidt, Wolfgang, Bergbauer, M., Kalla, M., Sebastian Eck, Rothbauer, U., Schmeinck, Anne, Bergbauer, Martin, Göbel Christine, Tim M. Strom, Göbel, Christine, Tim M Strom, Strom Tim M., Eck, Sebastian, Anne Schmeinck, Eck, S., Martin Bergbauer, Benet-Pagès, A., Kalla, Markus, Hammerschmidt Wolfgang, Rothbauer Ulrich, Strom, T.M., Markus Kalla, Ulrich Rothbauer, Kalla Markus, Anna Benet-Pagès   +36 more
core   +1 more source

A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants

Applications in Plant Sciences, EarlyView.
Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk, Cintia F. Marchetti, Ezequiel Petrillo, Fernando A. Rabanal, Detlef Weigel, Nicolás Bellora, M. Verónica Arana   +6 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source