Results 71 to 80 of about 254,703 (199)

Investigation of the Influence of Cytosine Methylation on DNA Flexibility [PDF]

Journal of Biological Chemistry, 1995
To test the influence of pyrimidine methyl groups on DNA flexibility and helix repeat, two sets of 14 mixed sequence DNA molecules, spanning a range of lengths from 158 to 180 base pairs, were cyclized with T4 DNA ligase. The two sets differed only in that the Cyt-5 positions of all cytosines (80-90 cytosine residues per molecule) were fully methylated
Y, Hodges-Garcia, P J, Hagerman
openaire   +2 more sources

Cytosine-Based TET Enzyme Inhibitors

, 2019
DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered ...
Beth G. Malachowsky (6298331), Martin Kruse (6298334), Kelly L. Wassarman (6298316), Joseph A. Alp (6298322), Emma I. Jarczyk (6298325), Gabriella N. L. Chua (6298313), Michael J. Bennett (172679), Andrew J. Kennedy (2196862), Nathanael J. Kuzio (6298328), Haoyu Sun (6298319)   +9 more
core   +1 more source

The epigenetic regulator Cfp1

Biomolecular Concepts, 2010
Numerous epigenetic modifications have been identified and correlated with transcriptionally active euchromatin or repressed heterochromatin and many enzymes responsible for the addition and removal of these marks have been characterized.
Skalnik David G.
doaj   +1 more source

Mechanistic insights into Cytosine-N3 Methylation by DNA Methyltransferase DNMT3A [PDF]

, 2019
Recently, it has been discovered that different DNA-(cytosine C5)-methyltransferases including DNMT3A generate low levels of 3mC [Rosic et al. (2018), Nat. Genet., 50, 452-459].
Jeltsch, Albert, Sarkies, Peter, Dukatz, Michael, Requena, Cristina E, Emperle, Max, Hajkova, Petra   +5 more
core   +1 more source

Single-base resolution quantitative genome methylation analysis in the model bacterium Helicobacter pylori by enzymatic methyl sequencing (EM-Seq) reveals influence of strain, growth phase, and methyl homeostasis

BMC Biology
Background Bacterial epigenetics is a rapidly expanding research field. DNA methylation by diverse bacterial methyltransferases (MTases) contributes to genomic integrity and replication, and many recent studies extended MTase function also to global ...
Lubna Patel, Florent Ailloud, Sebastian Suerbaum, Christine Josenhans   +3 more
doaj   +1 more source

PlantDeepMeth: A Deep Learning Model for Predicting DNA Methylation States in Plants

Plants
Cytosine DNA methylation (5mCs) is an important epigenetic modification in genomic research. However, the methylation states of some cytosine sites are not available due to the limitations of different studies, and there are few tools developed to deal ...
Zhongwei Guo, Wenyuan Fan, Chengcheng Cai, Kang Zhang, Xilin Hou, Ying Li, Feng Cheng   +6 more
doaj   +1 more source

Accurate Detection of Methylated Cytosine in Complex Methylation Landscapes

, 2016
Monitoring DNA methylation can be a useful biomarker for disease diagnosis and prognosis. However, monitoring the methylation status of a specific cytosine biomarker is often confounded by heterogeneous peripheral DNA methylation.
Ramkumar Palanisamy (649144), Ashley R. Connolly (1935241), Matt Trau (472531)   +2 more
core   +1 more source

Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea [PDF]

, 2014
Background: Brassica oleracea is a valuable vegetable species that has contributed to human health and nutrition for hundreds of years and comprises multiple distinct cultivar groups with diverse morphological and phytochemical attributes.
John Nixon, Denoeud, France, Parkin, Isobel AP, Annaliese S Mason, Town, Chris D, Huebert, Terry, Sharpe, Andrew G., Manoli, Sahana, Bancroft, Ian, France Denoeud, Sateesh Kagale, Robinson, Stephen J., Vivek Krishnakumar, Clarke, Carling, Links, Matthew G., Robinson, Stephen J, Wayne E Clarke, Guy Barker, Barker, Guy C., Shelby L Bidwell, Koh, Chushin, Moore, Jonathan D., Sharpe, Andrew G, Jacqueline Batley, Edwards, David, Clarke, Wayne E., Harry Belcram, Jérémy Just, Bidwell, Shelby L., Just, Jérémy, Carling Clarke, Jonathan Moore, Edwards, Dave, Nelson, Matthew N, David Edwards, Batley, Jacqueline, Matthew N Nelson, Stephen J Robinson, Sahana Manoli, Bidwell, Shelby L, Pires, J. Chris, Parkin, Isobel A. P., Chalhoub, Boulos, Terry Huebert, Andrew H Paterson, Krishnakumar, Vivek, Belcram, Harry, H., Walley, Peter G, Bender, Tricia, Tricia Bender, Town, Chris D., Nelson, Matthew N., King, Graham, J Pires, Mason, Annaliese S., Graham King, Pires, Chris J., Matthew G Links, Nixon, John, Chris D Town, Boulos Chalhoub, Links, Matthew G, Ian Bancroft, Belcram, Harry, Walley, Peter G., Mason, Annaliese S, Paterson, Andrew H, Walley, Peter Glen, Paterson, Andrew H., Moore, Jonathan, Barker, Guy, Kagale, Sateesh, Wang, Xiyin, Tang, Haibao, Pires, J Chris, Isobel AP Parkin, Pires, J., Andrew G Sharpe, Clarke, Wayne E, Xiyin Wang, Haibao Tang, Peter G Walley, Chushin Koh   +82 more
core   +1 more source

The binding of nuclear factors to the as-1 element in the CaMV 35S promoter is affected by cytosine methylation in vitro

, 2007
Transcriptional gene silencing (TCS) is often associated with an increased level of cytosine methylation in the affected promoters. The effect of methylation of the cauliflower mosaic virus (CaMV) 35S promoter sequence on its binding to factors present ...
O'Dell, M., Hellens, R.P., Kanazawa, A.
core   +1 more source

Methylome and Epialleles in Rice Epilines Selected for Energy Use Efficiency

Agronomy, 2018
Epigenetics offers important opportunities in breeding to improve the potential yield in a wide variety of crops. Starting from a pure breeder seed lot of a rice (Oryza sativa ssp.
Martin Schmidt, Marina Byzova, Cindy Martens, Marrit Peeters, Yog Raj, Shailesh Shukla, Tom Verwulgen, Marc DeBlock, Mieke Van Lijsebettens   +8 more
doaj   +1 more source