Results 31 to 40 of about 62,191 (286)

Turnover and function of DNA methylation at transcription factor binding sites [PDF]

, 2014
Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core   +1 more source

Global Analysis of Cytosine Methylation and Proteome Under Cold Treatment in Brassica napus

Journal of Integrative Agriculture, 2014
Cytosine methylation/demethylation plays pivotal roles in regulating gene expression at a genome-wide level. However, limited reports are available to reveal correlating changes of cytosine methylation and proteomic expression in Brassica napus so far ...
Fang WEI, Jie HU, Ming-zhu CUI, Yan-hui ZHANG, Yun-ling LI, Bao-ming TIAN   +5 more
doaj   +1 more source

Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1 [PDF]

, 2011
Several mammalian proteins involved in chromatin and DNA modification contain CXXC zinc finger domains. We compared the structure and function of the CXXC domains in the DNA methyltransferase Dnmt1 and the methylcytosine dioxygenase Tet1.
Rottach Andrea, Frauer, C., Wang Mengxi, Meilinger, D., Spada, Fabio, Andrea Rottach, Leonhardt, Heinrich, Weihua Qin, Qin, W., Frauer, Carina, Bultmann, Sebastian, Daniela Meilinger, Frauer Carina, Fellinger, K., Qin Weihua, Söding Johannes, Rottach, A., Hasenöder, Stefan, Qin, Weihua, Leonhardt Heinrich, Spada, F., Spada Fabio, Hasenoeder, S., Heinrich Leonhardt, Fellinger, Karin, Meilinger Daniela, Stefan Hasenöder, Mengxi Wang, Johannes Söding, Wang, M., Fabio Spada, Fellinger Karin, Söding, J., Hasenöder Stefan, Meilinger, Daniela, Söding, Johannes, Wang, Mengxi, Bultmann Sebastian, Bultmann, S., Rottach, Andrea, Leonhardt, H., Wutz, Anton, Carina Frauer, Sebastian Bultmann, Karin Fellinger   +44 more
core   +1 more source

Epigenetic regulation during fetal femur development: DNA methylation matters [PDF]

, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
Oreffo Richard O. C., Oreffo, Richard O. C., Antonio Gonzalez, González Martínez-Pedrayo, Antonio, Imagawa, K., Richard O C Oreffo, de Andrés María C., Gonzalez, A., Roach Helmtrud I., Wilson, David I., Kingham, Emmajayne, Oreffo, R.O., Kingham Emmajayne, Helmtrud I Roach, Oreffo, Richard O C, Gomez-Reino, J.J., Emmajayne Kingham, Kei Imagawa, María C de Andrés, Wilson, D.I., Roach, Helmtrud I, Wilson David I., de Andrés, María C., Imagawa, Kei, Roach, Helmtrud I., De Andrés González, Mª Carmen, Imagawa Kei, Wilson, David I, Neves, Nuno M., David I Wilson, Gonzalez, Antonio, Roach, H.I., Kingham, E., Gonzalez Antonio, de Andrés, M.C.   +34 more
core   +1 more source

Systematic prediction of DNA shape changes due to CpG methylation explains epigenetic effects on protein–DNA binding

Epigenetics & Chromatin, 2018
Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited.
Satyanarayan Rao, Tsu-Pei Chiu, Judith F. Kribelbauer, Richard S. Mann, Harmen J. Bussemaker, Remo Rohs   +5 more
doaj   +1 more source

From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia [PDF]

Epigenetics, 2009
The role of methylation in the history of psychiatry has traversed a storied path. The original trans-methylation hypothesis was proposed at a time when chlorpromazine had been synthesized but not yet marketed as an antipsychotic (Thorazine).
Dennis R, Grayson, Ying, Chen, Erbo, Dong, Marija, Kundakovic, Alessandro, Guidotti   +4 more
openaire   +2 more sources

Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection

Biology, 2020
DNA cytosine methylation is one of the main epigenetic mechanisms in higher eukaryotes and is considered to play a key role in transcriptional gene silencing.
Miryam Pérez-Cañamás, Elizabeth Hevia, Carmen Hernández   +2 more
doaj   +1 more source

Correction: Dissecting cytosine methylation mechanics of dysmetabolism. [PDF]

Aging (Albany NY), 2019
Cencioni C, Gaetano C, Spallotta F.
europepmc   +3 more sources

The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana. [PDF]

PLoS Genetics, 2010
Eukaryotic DNA cytosine methylation can be used to transcriptionally silence repetitive sequences, including transposons and retroviruses. This silencing is stable between cell generations as cytosine methylation is maintained epigenetically through DNA ...
Ian R Henderson, Angelique Deleris, William Wong, Xuehua Zhong, Hang Gyeong Chin, Gregory A Horwitz, Krystyna A Kelly, Sriharsa Pradhan, Steven E Jacobsen   +8 more
doaj   +1 more source

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria [PDF]

Proceedings of the National Academy of Sciences, 2011
Mitochondrial DNA (mtDNA) has been reported to contain 5-methylcytosine (5mC) at CpG dinucleotides, as in the nuclear genome, but neither the mechanism generating mtDNA methylation nor its functional significance is known. We now report the presence of 5-hydroxymethylcytosine (5hmC) as well as 5mC in mammalian mtDNA, suggesting that previous studies ...
Lisa S, Shock, Prashant V, Thakkar, Erica J, Peterson, Richard G, Moran, Shirley M, Taylor   +4 more
openaire   +2 more sources