Results 31 to 40 of about 254,703 (199)

Dynamics of Methylated Cytosine Flipping by UHRF1 [PDF]

Journal of the American Chemical Society, 2017
DNA methylation patterns, which are critical for gene expression, are replicated by DNA methyltransferase 1 (DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins. This replication is initiated by the recognition of hemimethylated CpG sites and further flipping of methylated cytosines (mC) by the Set and Ring Associated ...
Bronner, Christian, Kilin, Vasyl, Gavvala, Krishna, Barthes, Nicolas, Michel, Benoît, Shin, Dongwon, Boudier, Christian, Mauffret, Olivier, Yashchuk, Valeriy, Mousli, Marc, Ruff, Marc, Granger, Florence, Eiler, Sylvia, Tor, Yitzhak, Burger, Alain, Mély, Yves   +15 more
openaire   +5 more sources

Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1 [PDF]

, 2011
Several mammalian proteins involved in chromatin and DNA modification contain CXXC zinc finger domains. We compared the structure and function of the CXXC domains in the DNA methyltransferase Dnmt1 and the methylcytosine dioxygenase Tet1.
Rottach Andrea, Frauer, C., Wang Mengxi, Meilinger, D., Spada, Fabio, Andrea Rottach, Leonhardt, Heinrich, Weihua Qin, Qin, W., Frauer, Carina, Bultmann, Sebastian, Daniela Meilinger, Frauer Carina, Fellinger, K., Qin Weihua, Söding Johannes, Rottach, A., Hasenöder, Stefan, Qin, Weihua, Leonhardt Heinrich, Spada, F., Spada Fabio, Hasenoeder, S., Heinrich Leonhardt, Fellinger, Karin, Meilinger Daniela, Stefan Hasenöder, Mengxi Wang, Johannes Söding, Wang, M., Fabio Spada, Fellinger Karin, Söding, J., Hasenöder Stefan, Meilinger, Daniela, Söding, Johannes, Wang, Mengxi, Bultmann Sebastian, Bultmann, S., Rottach, Andrea, Leonhardt, H., Wutz, Anton, Carina Frauer, Sebastian Bultmann, Karin Fellinger   +44 more
core   +2 more sources

Systematic prediction of DNA shape changes due to CpG methylation explains epigenetic effects on protein–DNA binding

Epigenetics & Chromatin, 2018
Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited.
Satyanarayan Rao, Tsu-Pei Chiu, Judith F. Kribelbauer, Richard S. Mann, Harmen J. Bussemaker, Remo Rohs   +5 more
doaj   +1 more source

MSAP markers and global cytosine methylation in plants: a literature survey and comparative analysis for a wild-growing species [PDF]

, 2015
Methylation of DNA cytosines affects whether transposons are silenced and genes are expressed, and is a major epigenetic mechanism whereby plants respond to environmental change.
Herrera, Carlos M., Alonso, Conchita, Bazaga, Pilar, Pérez, Ricardo, Medrano, Mónica   +4 more
core   +1 more source

Cytosine methylation of the sequence GATC in a mycoplasma [PDF]

Journal of Bacteriology, 1982
Mycoplasma virus L2 is subject to host-specific restriction and modification in Acholeplasma laidlawii strains JA1 and K2. We have examined the DNAs from both host cells and viruses propagated on these strains with respect to susceptibility to cleavage by restriction endonucleases and for DNA base modifications.
K, Dybvig, D, Swinton, J, Maniloff, S, Hattman   +3 more
openaire   +2 more sources

Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection

Biology, 2020
DNA cytosine methylation is one of the main epigenetic mechanisms in higher eukaryotes and is considered to play a key role in transcriptional gene silencing.
Miryam Pérez-Cañamás, Elizabeth Hevia, Carmen Hernández   +2 more
doaj   +1 more source

The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana. [PDF]

PLoS Genetics, 2010
Eukaryotic DNA cytosine methylation can be used to transcriptionally silence repetitive sequences, including transposons and retroviruses. This silencing is stable between cell generations as cytosine methylation is maintained epigenetically through DNA ...
Ian R Henderson, Angelique Deleris, William Wong, Xuehua Zhong, Hang Gyeong Chin, Gregory A Horwitz, Krystyna A Kelly, Sriharsa Pradhan, Steven E Jacobsen   +8 more
doaj   +1 more source

From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia [PDF]

Epigenetics, 2009
The role of methylation in the history of psychiatry has traversed a storied path. The original trans-methylation hypothesis was proposed at a time when chlorpromazine had been synthesized but not yet marketed as an antipsychotic (Thorazine).
Dennis R, Grayson, Ying, Chen, Erbo, Dong, Marija, Kundakovic, Alessandro, Guidotti   +4 more
openaire   +2 more sources

Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.

PLoS Genetics, 2014
Epigenetic marks such as cytosine methylation are important determinants of cellular and whole-body phenotypes. However, the extent of, and reasons for inter-individual differences in cytosine methylation, and their association with phenotypic variation ...
Michelle D Johnson, Michael Mueller, Martyna Adamowicz-Brice, Melissa J Collins, Pascal Gellert, Klio Maratou, Prashant K Srivastava, Maxime Rotival, Shahena Butt, Laurence Game, Santosh S Atanur, Nicholas Silver, Penny J Norsworthy, Sarah R Langley, Enrico Petretto, Michal Pravenec, Timothy J Aitman   +16 more
doaj   +1 more source

DNA methylation in chromatin - complexes and mechanisms [PDF]

, 2010
The DNA in the eukaryotic genome is packaged into chromatin whose basic repeating unit is the nucleosome consisting of 147bp of DNA wrapped around an octameric histone core.
Felle, Max
core   +1 more source