Results 11 to 20 of about 57,661 (242)
Mammalian cytosine methylation at a glance [PDF]
Journal of Cell Science, 2009 In mammals, methylation at symmetric CpG dinucleotides is necessary for the heritable silencing and regulation of many different classes of DNA sequences. These include highly abundant retrotransposons, such as the long terminal repeat (LTR)-based endogenous retroviruses, [e.g.
Steen K T, Ooi +2 more
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Cytosine Methylation: Remaining Faithful [PDF]
Current Biology, 2008 DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that increases the fidelity of maintenance methylation.
Ooi, Steen K.T., Bestor, Timothy H.
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Cytosine methylation and mammalian development [PDF]
Genes & Development, 1999 Programmed methylation and demethylation of regulatory sequences has been proposed to play a central role in vertebrate development. We report here that the methylation status of the 5′ regions of a panel of tissue-specific genes could not be correlated with expression in tissues of fetal and newborn mice.
C P, Walsh, T H, Bestor
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The methylation landscape of giga-genome and the epigenetic timer of age in Chinese pine
Nature Communications, 2023 DNA methylation level declines during aging of mammals. Here, the authors report single-base resolution landscape of cytosine DNA methylation at different ages of Chinese pine and show that the global cytosine DNA methylation gradually increases as age ...
Jiang Li +7 more
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Experimental and Computational Approaches for Non-CpG Methylation Analysis
Epigenomes, 2022 Cytosine methylation adjacent to adenine, thymine, and cytosine residues but not guanine of the DNA is distinctively known as non-CpG methylation. This CA/CT/CC methylation accounts for 15% of the total cytosine methylation and varies among different ...
Deepa Ramasamy +3 more
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Determination of the presence of 5-methylcytosine in Paramecium tetraurelia. [PDF]
PLoS ONE, 2018 5-methylcytosine DNA methylation regulates gene expression and developmental programming in a broad range of eukaryotes. However, its presence and potential roles in ciliates, complex single-celled eukaryotes with germline-somatic genome specialization ...
Aditi Singh +5 more
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The DNA methylation level against the background of the genome size and t-heterochromatin content in some species of the genus Secale L [PDF]
PeerJ, 2017 Methylation of cytosine in DNA is one of the most important epigenetic modifications in eukaryotes and plays a crucial role in the regulation of gene activity and the maintenance of genomic integrity.
Anna Kalinka +2 more
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Frontiers in Genetics, 2015 DNA cytosine methylation is a widespread epigenetic mechanism in eukaryotes, and plant genomes commonly are densely methylated. Genomic methylation can be associated with functional consequences such as mutational events, genomic instability or altered ...
Conchita eAlonso +3 more
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Cytosine methylation alteration in natural populations of Leymus chinensis induced by multiple abiotic stresses. [PDF]
PLoS ONE, 2013 BACKGROUND: Human activity has a profound effect on the global environment and caused frequent occurrence of climatic fluctuations. To survive, plants need to adapt to the changing environmental conditions through altering their morphological and ...
Yingjie Yu +8 more
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Dynamic bimodal changes in CpG and non-CpG methylation genome-wide upon CGGBP1 loss-of-function
BMC Research Notes, 2018 Objectives Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine methylation regulatory
Divyesh Patel +3 more
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