Results 11 to 20 of about 254,703 (199)
Accurate Detection of Methylated Cytosine in Complex Methylation Landscapes
Analytical Chemistry, 2013 Monitoring DNA methylation can be a useful biomarker for disease diagnosis and prognosis. However, monitoring the methylation status of a specific cytosine biomarker is often confounded by heterogeneous peripheral DNA methylation. To address this issue, molecular inversion probes were designed with inosine strategically positioned to complement ...
Palanisamy, Ramkumar +2 more
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Global Analysis of Cytosine Methylation and Proteome Under Cold Treatment in Brassica napus
Journal of Integrative Agriculture, 2014 Cytosine methylation/demethylation plays pivotal roles in regulating gene expression at a genome-wide level. However, limited reports are available to reveal correlating changes of cytosine methylation and proteomic expression in Brassica napus so far ...
Fang WEI +5 more
doaj +2 more sources
Cytosine Methylation: Quantitation by Automated Genomic Sequencing and GENESCANTM Analysis
BioTechniques, 1996 Bisulfite treatment and PCR amplification of genomic DNA permits the methylation analysis of any cytosine residue in a target sequence. By cloning and sequencing the PCR product, the methylation of individual molecules can be determined, whereas direct ...
Cheryl L. Paul, Susan J. Clark
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Information Thermodynamics of Cytosine DNA Methylation. [PDF]
PLoS ONE, 2016 Cytosine DNA methylation (CDM) is a stable epigenetic modification to the genome and a widespread regulatory process in living organisms that involves multicomponent molecular machines.
Robersy Sanchez, Sally A Mackenzie
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Cytosine methylation regulates DNA bendability depending on the curvature. [PDF]
Chem Sci, 2022 Cytosine methylation plays an essential role in many biological processes, such as nucleosome inactivation and regulation of gene expression. The modulation of DNA mechanics may be one of the regulatory mechanisms influenced by cytosine methylation ...
Yeou S +5 more
europepmc +2 more sources
Mammalian cytosine methylation at a glance [PDF]
Journal of Cell Science, 2009 In mammals, methylation at symmetric CpG dinucleotides is necessary for the heritable silencing and regulation of many different classes of DNA sequences. These include highly abundant retrotransposons, such as the long terminal repeat (LTR)-based endogenous retroviruses, [e.g.
Steen K T, Ooi +2 more
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Cytosine Methylation: Remaining Faithful [PDF]
Current Biology, 2008 DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that increases the fidelity of maintenance methylation.
Ooi, Steen K.T., Bestor, Timothy H.
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Cytosine methylation and mammalian development [PDF]
Genes & Development, 1999 Programmed methylation and demethylation of regulatory sequences has been proposed to play a central role in vertebrate development. We report here that the methylation status of the 5′ regions of a panel of tissue-specific genes could not be correlated with expression in tissues of fetal and newborn mice.
C P, Walsh, T H, Bestor
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Transgenerational inheritance of engineered cytosine methylation in mice. [PDF]
Cell Res, 2023 Knott MML, Rechavi O.
europepmc +3 more sources
Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase [PDF]
, 2013 The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
Stier, Ildikó +5 more
core +2 more sources