Results 121 to 130 of about 160,622 (298)

Validation of the WID‐CIN Methylation Test for Detection of Cervical Intraepithelial Neoplasia Grade 3 or Worse in an Independent Cohort

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Many cervical screening programmes rely on cytology for triage of high‐risk human papillomavirus (hrHPV) positive women. However, cytological triage has variable and often limited sensitivity, and its availability can be restricted in resource‐poor settings.
Laura Burney Ellis   +9 more
wiley   +1 more source

Global DNA methylation level of different types of cytosine.

open access: yes, 2012
Global DNA methylation level of different types of cytosine.
Shu-Jia Huang (187041)   +11 more
core   +1 more source

Maternal overweight and obesity during pregnancy and sex‐dependent dysregulation of the materno‐fetal stress axis

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Maternal obesity and excess gestational weight gain (GWG) are linked to adverse perinatal outcomes, potentially via disruption of the maternal–fetal stress axis. Placental HSD11B2 protects the fetus from excess glucocorticoids and may influence fetal programming during maternal metabolic stress.
Thorsten Braun   +13 more
wiley   +1 more source

Impact of cytosine instability on single-stranded DNA virus evolution

open access: yes, 2015
Single-stranded DNA (ssDNA) viruses mutate and evolve at similar rates to RNA viruses, and more rapidly than double-stranded DNA viruses. Unlike RNA viruses, the mechanism underlying these rates is unknown.

core  

Sorghum T2T pangenome highlights comprehensive genomic variation

open access: yesiMetaOmics, EarlyView.
Three newly assembled telomere‐to‐telomere (T2T) genomes representing wild, landrace, and transformable germplasm were integrated with seven publicly available T2T genomes to construct a graph‐based pangenome. Comparative analyses revealed extensive centromere divergence, including distinct CEN137 monomer and CEN274 dimer organization, and showed that ...
Lihua Wang   +10 more
wiley   +1 more source

Molecular structure of cytosine (A) and 5-methylcytosine (B).

open access: yes, 2014
Molecular structure of cytosine (A) and 5-methylcytosine (B).
Maria Luiza S. Mello (191454)   +2 more
core   +1 more source

Cross species metabolic complementation of vitamin K2 biosynthesis determines emergent suppression of tomato Fusarium wilt

open access: yesiMeta, EarlyView.
Multi‐omics approaches have revealed a cross‐species functional emergence phenomenon leading to emergent suppression of Fusarium wilt. We show that a three‑species consortium exhibits emergent suppression of Fusarium oxysporum f. sp. lycopersici (Fol) that is absent in single or pairwise cultures.
Lizhi Zhao   +8 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

open access: yesiNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong   +5 more
wiley   +1 more source

The regulation of cytosine deaminase in Salmonella typhimurium

open access: yes, 1980
Vita.The regulation of the enzyme cytosine deaminase was investigated at the level of enzyme synthesis and at the level of enzyme activity in Salmonella typhimurium.
West, Thomas Patrick
core  

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

open access: yesInterdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li   +7 more
wiley   +1 more source

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