Results 151 to 160 of about 131,177 (265)

Efficient and Safe Knockout of <i>AR</i> and <i>DMRT1</i> Mediated by Cytosine Base Editors in Chicken DF-1 and PGCs. [PDF]

Vet Sci
Gao X, Tang N, Zhao Z, He Y, Shen Y, Zou X, Luo C.   +6 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

On the ozonation of anti-SARS-CoV-2 substances and their nucleoside analogues for mechanistic understanding of the ozone induced transformation using HPLC-ESI-Q-TOF-HRMS. [PDF]

RSC Adv
Bartels I, Hoffmann-Jacobsen K, Schmidt TC, Jaeger M.   +3 more
europepmc   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Characterizing cytosine methylation of polymorphic transposable element insertions using the human pangenome resources. [PDF]

Genome Res
Zhuo X, Tomlinson C, Belter EA, Kuntala PK, Saintilnord WN, Jiang J, Lindsay T, Macias-Velasco JF, Fulton RS, Wang T, Human Pangenome Reference Consortium.   +10 more
europepmc   +1 more source

Cyclopentenyl Cytosine [PDF]

, 2020
openaire   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Genome-wide maps of CPD deamination in yeast reveal the impact of DNA sequence context and nucleosome architecture on cytosine deamination rates. [PDF]

Genome Res
Laughery MF, Stark B, Morledge-Hampton B, Roberts SA, Wyrick JJ.   +4 more
europepmc   +1 more source

Benign by design: A paradigm shift in cosmetic ingredient development

International Journal of Cosmetic Science, EarlyView.
Benign by design strategies enable the creation of biodegradable cosmetic ingredients, reducing environmental persistence while maintaining the intended biological activity. This work compiles design rules and tools to guide the development of more sustainable molecules for the cosmetics industry.
Sandra Mota, Klaus Kümmerer, Isabel Martins de Almeida, Emília Sousa   +3 more
wiley   +1 more source

Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity. [PDF]

RSC Chem Biol
Katsuyama M, Matsubayashi T, Ying Y, Mon SSL, Kuroda T, Yoshida-Tanaka K, Hara RI, Yamada T, Ui-Tei K, Yoshioka K.   +9 more
europepmc   +1 more source