Results 151 to 160 of about 160,622 (298)

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Thermodynamic Mapping of C5-Substituent Autoxidation Pathways in 1,5-Dimethylcytosine: A Quantum Chemical Study. [PDF]

J Comput Chem
Korotenko V, Zipse H.
europepmc   +1 more source

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Cuprous Ions Binding to Cytosine and Guanine Oligonucleotides. [PDF]

Chembiochem
Pereira J, Brachet M, Barthélémy P, Alies B.   +3 more
europepmc   +1 more source

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source

A theoretical and experimental framework enables low-coverage sequencing for accurate quantification of genome-wide cytosine modification levels. [PDF]

NAR Genom Bioinform
Loo CE, Fowler JM, Zhu H, Krapp C, Zhu R, Bartolomei MS, Zhou W, Kohli RM.   +7 more
europepmc   +1 more source

A photoimmune synergizing RNA interference technology for highly effective antitumor treatment

Smart Molecules, EarlyView.
We developed a red‐light‐activated small‐molecule photosensitizer FNBS, which enables simultaneous photodynamic immunotherapy and RNA interference. FNBS can induce pyroptosis, immunogenic cell death and RNA degradation, avoiding the carrier‐dependent delivery drawbacks of conventional RNAi therapy, converting cold tumors into hot tumors and ...
Xiang Xia, Bingbing Wu, Xueze Zhao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng   +6 more
wiley   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

Cytosine-Rich DNA Aptamers Reveal Recognition Principles for Structurally Diverse Lipopolysaccharides. [PDF]

ACS Meas Sci Au
Tatsumi A, Koyama N, Yamashita M.
europepmc   +1 more source

In Situ Construction of Phosphorus‐Containing Crosslinked Urethane Network Combined With Ammonium Polyphosphate via Reactive Blending for Enhancing Flame Retardancy and Anti‐Dripping Performance of Polylactic Acid Composites

Safety Science and Technology, EarlyView.
By in situ reaction blending, DOPO‐HQ and THEIC were added to PLA with MDI to construct a phosphorus containing polyurethane network, which significantly improved the flame retardant and anti‐dripping properties of polylactic acid composites. ABSTRACT Polylactic acid (PLA) is highly flammable and prone to severe melt dripping during combustion, which ...
Chiyuan Chen, Sadiqa Khan, Hongyu Yang, Xiaming Feng, Chaojun Wan   +4 more
wiley   +1 more source