Results 251 to 260 of about 52,861 (267)

Alcohol and aging: Next‐generation epigenetic clocks predict biological age acceleration in individuals with alcohol use disorder

Alcohol, Clinical and Experimental Research, EarlyView.
Our study investigated the performance of five epigenetic clocks by evaluating associations with alcohol use disorder (AUD) and various alcohol‐related phenotypes. Both DNAm GrimAge versions were associated with AUD and alcohol behaviors/clinical measures in the total sample and age subgroups.
Tyler A. Perlstein, Jeesun Jung, Alexandra C. Wagner, Joshua Reitz, Josephin Wagner, Daniel B. Rosoff, Falk W. Lohoff   +6 more
wiley   +1 more source

Complex population genetic structure of the bark beetle predator Thanasimus formicarius (L.) (Coleoptera: Cleridae) across its European range

Agricultural and Forest Entomology, EarlyView.
Abstract Thanasimus formicarius (L.) (Coleoptera: Cleridae) is an important bark beetle predator and can reduce bark beetle population densities of some of the most severe forest pests in Europe. We analysed the population genetics and phylogeography of T.
Eva Papek, Amina Derlić, Markus Melin, Alain Roques, Dragos Cocos, Martin L. Schroeder, Milan Pernek, Dimitrios N. Avtzis, Paulius Zolubas, David T. Williams, Juan A. Pajares, Oğuzhan Sarikaya, Roman Pavlin, Sevdalin Belilov, Martin M. Gossner, M. Lukas Seehausen, Anna Wierzbicka, Lara Kundtner, Christian Stauffer, Martin Schebeck   +19 more
wiley   +1 more source

The molecular basis of lactase persistence: Linking genetics and epigenetics

Annals of Human Genetics, EarlyView.
Abstract Lactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Céleste E. Cohen, Dallas M. Swallow, Catherine Walker   +2 more
wiley   +1 more source

Semen cryopreservation and storage in liquid nitrogen: Impact on chromatin compaction

Andrology, EarlyView.
Abstract Background Sperm cryopreservation is a consolidate option for long‐term male fertility preservation. The freezing/thawing procedure causes detrimental effects to spermatozoa, including damage to viability, motility, membrane composition, and DNA, whereas the effect on sperm chromatin compaction is less studied.
Lara Tamburrino, Giulia Traini, Maria Emanuela Ragosta, Sara Dabizzi, Sara Vezzani, Flavia Scarpa, Linda Vignozzi, Elisabetta Baldi, Sara Marchiani   +8 more
wiley   +1 more source

Effects of AZFc (b2/b4, b1/b3, b2/b3, and gr/gr) deletions and primary duplications on the outcomes of the first intracytoplasmic sperm injection treatment cycle: A single‐center retrospective cohort study

Andrology, EarlyView.
Abstract Background Current advances in high‐throughput sequencing technology enable the precise identification of Y chromosome microdeletion and primary duplication in infertile couples, but the mechanism and clinical significance of these mutations in assisted reproductive techniques remain unclear.
Linlin Li, Xiangyin Liu, Xinying Wang, Hongguo Zhang, Ruizhi Liu   +4 more
wiley   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

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Eukaryotic cytosine methyltransferases.

Annual Review of Biochemistry, 2005
Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows ...
M. Goll, T. Bestor
semanticscholar   +1 more source

MSAP markers and global cytosine methylation in plants: a literature survey and comparative analysis for a wild‐growing species

Molecular Ecology Resources, 2016
Methylation of DNA cytosines affects whether transposons are silenced and genes are expressed, and is a major epigenetic mechanism whereby plants respond to environmental change.
C. Alonso, R. Pérez, P. Bazaga, M. Medrano, C. Herrera   +4 more
semanticscholar   +1 more source

Benchmark Thermochemistry for Biologically Relevant Adenine and Cytosine. A Combined Experimental and Theoretical Study.

Journal of Physical Chemistry A, 2015
The thermochemical properties available in the literature for adenine and cytosine are in disarray. A new condensed phase standard (p° = 0.1 MPa) molar enthalpy of formation at T = 298.15 K was measured by using combustion calorimetry.
V. N. Emel’yanenko, D. Zaitsau, E. Shoifet, F. Meurer, S. P. Verevkin, C. Schick, C. Held   +6 more
semanticscholar   +1 more source

Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Nature Biotechnology, 2022
Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan, Mengjia Hong, Dan Zhang, Changming Luan, Shun Zhang, Hao Wu, Hongyi Gao, Sijia Bai, Changqing Li, Ruoyi Ding, Niannian Xue, Zhixin Lei, Yuting Chen, Yuting Guan, S. Siwko, Yiyun Cheng, Gaojie Song, Liren Wang, C. Yi, Ming-Yu Liu, Dali Li   +24 more
semanticscholar   +1 more source