Results 241 to 250 of about 160,622 (298)

Protonation of cytosine in DNA

Biopolymers, 1966
AbstractSpectrophotometric acid titrations of DNA samples of different GC content were performed at different wavelengths. From the acid titration profile and absorbance changes of deoxycytidine‐5′‐monophosphate and DNA the extent of protonated cytosine within the DNA double‐stranded molecule was estimated (pK 3.65 at 25°C. in 0.02M KCl).
C, Zimmer, H, Venner
openaire   +2 more sources

Enzymology of cytosine arabinoside

Medical and Pediatric Oncology, 1982
The enzymes responsible for the metabolism of Ara-C and its metabolites in human cells are described. The relevance of the properties of those enzymes to the action of Ara-C is discussed.
Y C, Cheng, R L, Capizzi
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Restricted rotation in crystalline cytosine and cytosine monohydrate

Transactions of the Faraday Society, 1970
The n.m.r. parameters T1 and T1ρ, the spin-lattice relaxation times in the laboratory- and rotating-frames, respectively, have been utilized to study the molecular motions that occur in polycrystalline samples of cytosine and cytosine hydrate in the range 130–293 K. The deuterated analogues have also been studied.
I. Adams, G. Parry Jones, J. M. Thomas
openaire   +1 more source

Methylation Inhibitors Can Increase the Rate of Cytosine Deamination by (Cytosine-5)-DNA Methyltransferase.

Nucleic Acids Research, 1996
The target cytosines of (cytosine-5)-DNA methyltransferases in prokaryotic and eukaryotic DNA show increased rates of C→T transition mutations compared to non-target cytosines.
Peter A Jones, Jean-Marc Zingg, H Rapoport   +2 more
exaly   +2 more sources

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Annual Review of Biochemistry, 2005
▪ Abstract  Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows methylated genomes with the ability to repress specific promoters in a manner that is ...
Mary Grace, Goll, Timothy H, Bestor
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Solvolyses of Cytosine and Cytidine

Journal of Pharmaceutical Sciences, 1972
It has been confirmed by UV spectrophotometry and TLC that cytosine and cytidine deaminate to uracil and uridine, respectively, at all pH values. These products slowly degrade further in strongly alkaline solutions. Cytidine also undergoes a parallel degradation in strongly alkaline solutions to a nonchromophoric compound, which can be assigned to a ...
E R, Garrett, J, Tsau
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Tautomeric exchange in cytosine

Biochemical and Biophysical Research Communications, 1971
Abstract It has long been noted that the H 5 proton of cytosine and its related derivatives exhibits unusually broad resonances in the pmr spectrum under certain conditions of temperature and solution pD. We have examined this phenomenon as a function of temperature, solution pD as well as the external magnetic field, and have shown that the line ...
G C, Lee, J H, Prestegard, S I, Chan
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The SPR Sensor Detecting Cytosine−Cytosine Mismatches

Journal of the American Chemical Society, 2003
We have synthesized the first surface plasmon resonance (SPR) sensor that detects cytosine-cytosine (C[bond]C) mismatches in duplex DNA by immobilizing aminonaphthyridine dimer on the gold surface. The ligand consisting of two 2-aminonaphthyridine chromophores and an alkyl linker connecting them strongly stabilized the C[bond]C mismatches regardless of
Kobori, A, Horie, S, Suda, H, Saito, I, Nakatani, K   +4 more
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The Full Cytosine‐Cytosine Base Paring: Self‐Assembly and Crystal Structure

Chemistry – A European Journal, 2023
AbstractThe synthesis of self‐assembly systems that can mimic partial biological behaviours require ingenious and delicate design. For decades, scientists are committed to exploring new base pairing patterns using hydrogen bonds directed self‐assembly of nucleotides.
Zhongkui Li, Wenjing Song, Yanhong Zhu, Li Yan, Xue Zhong, Menglei Zhang, Hui Li   +6 more
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How to Distinguish Methyl-Cytosine from Cytosine with High Fidelity

Journal of Molecular Biology, 2012
Methylation of cytosines in the DNA is central to the epigenetic code. The patterns along the DNA formed by these chemical marks instruct the cell which proteins to express and their faithful maintenance after replication are vital to the organism's life.
Caterina, Bianchi, Ronen, Zangi
openaire   +2 more sources