Results 301 to 310 of about 560,464 (384)

TMEM16A Maintains Acrosomal Integrity Through ERK1/2, RhoA, and Actin Cytoskeleton During Capacitation [PDF]

Ana L. Roa‐Espitia, Tania Reyes‐Miguel, Monica L. Salgado‐Lucio, Joaquín Cordero‐Martínez, Dennis Tafoya-Domínguez, Enrique O. Hernández‐González   +5 more
openalex   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

The effects of mechanical stimulation on the morphology and function of spinal ligament cells. [PDF]

BMC Musculoskelet Disord
Tang T, Wang F, Liu X, Liu S, Zhou Z, Chen L.   +5 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Generation of a primary culture of chick embryo enterocytes to evaluate the effects of fumonisin B1 and deoxynivalenol on cell morphology, actin filaments and nuclei. [PDF]

PLoS One
Uribe-Rivera J, Nava-Ramirez MJ, Escobedo-Aguirre S, Del Río-García JC, Jardón-Xicoténcatl S, García-Tovar CG, Ávila-González E, Gomez-Verduzco G.   +7 more
europepmc   +1 more source

MOESM3 of The human, F-actin-based cytoskeleton as a mutagen sensor

, 2017
Nicolette Clark, Carlos Garcia Galindo, Vandan Patel, Michele Parry, Rebecca Stoll, John M. Yavorski, Elizabeth Pinkason, Edna Johnson, Chelsea Walker, Joseph Johnson, Wade J. Sexton, Domenico Coppola, George Blanck   +12 more
openalex   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

<i>Toxoplasma</i> effector <i>Tg</i>WIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex. [PDF]

mBio
Morales P, Kramer DA, de Moraes de Siqueira C, Brown AJ, Sangaré LO, Chen B, Saeij JPJ.   +6 more
europepmc   +1 more source

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

, 2013
Yuan He, Dong Li, Sara Cook, Mee‐Sup Yoon, Ashish Kapoor, Christopher V. Rao, Paul J. A. Kenis, Jie Chen, Fei Wang   +8 more
openalex   +2 more sources

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source