Results 131 to 140 of about 336,446 (348)
Dynamic association of human mRNP proteins with mitochondrial tRNAs in the cytosol [PDF]
, 2018 Beáta E. Jády +2 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source
Reduction of disulphide bonds in proteins mixed disulphides catalysed by a thioltransferase in rat liver cytosol [PDF]
, 1975 Bengt Mannervik, Kent Axelsson
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, 2006 The crowded cytosol is a special environment where weak interactions can be important. Here many macromolecules are close to the limits of their solubility, a condition conducive to weak, but specific, entropy-driven molecular interactions. In addition to being under evolutionary constraint to preserve the functions of their own products, genes ...
openaire +1 more source
Advanced Science, EarlyView.CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong +5 more
wiley +1 more source
A Possible New Nucleoside Diphosphatase from the Cytosol of Soybean and Alfalfa Nodules [PDF]
, 1977 Robert E. Hunt +2 more
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Advanced Science, EarlyView.Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu +17 more
wiley +1 more source