Results 151 to 160 of about 256,621 (293)

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

open access: yesAdvanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song   +13 more
wiley   +1 more source

A Glycoprotein Set Specifically Associated with the Surface and Cytosol of Human Breast Carcinoma Cells [PDF]

open access: bronze, 1978
Julia P. Leung   +3 more
openalex   +1 more source

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

open access: yesAdvanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu   +8 more
wiley   +1 more source

Subcellular plant carbohydrate metabolism under elevated temperature. [PDF]

open access: yesPlant Physiol
Seydel C   +4 more
europepmc   +1 more source

A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma

open access: yesAdvanced Science, EarlyView.
The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye   +21 more
wiley   +1 more source

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