Results 181 to 190 of about 453,295 (313)

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

open access: yesAdvanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen   +9 more
wiley   +1 more source

Uncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics. [PDF]

open access: yesProc Natl Acad Sci U S A
Peng Z   +8 more
europepmc   +1 more source

Evidence for binding of gastrin to ligandin, a cell cytosol protein [PDF]

open access: bronze, 1975
R. E. Kirsch   +5 more
openalex   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

open access: yesAdvanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun   +16 more
wiley   +1 more source

Transformation of the glucocorticoid receptor in rat liver cytosol by lysosomal enzymes.

open access: hybrid, 1979
Jan Carlstedt‐Duke   +4 more
openalex   +1 more source

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

open access: yesAdvanced Science, EarlyView.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai   +8 more
wiley   +1 more source

Spatial protein redistribution: wandering but not lost. [PDF]

open access: yesCell Mol Life Sci
Abayed FAA   +6 more
europepmc   +1 more source

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